Article
Chemistry, Multidisciplinary
Guang-Jin Shi, Ke-Ke Tan, Shu-Yang Liu, Hao Zhang, Hao-Ran Hu, Kun-Peng Wang, Liang-Zhong Xu, Meng Li, Zhi-Qiang Hu
Summary: A new fluorescent emitter based on pi-extended benzothiadiazole was synthesized, which displayed excellent performance in a fluorescent OLED, including a large molar extinction coefficient, a high quantum yield, and a large radiative decay rate. The resulting TADF-sensitized fluorescent OLED exhibited high efficiency in device performance.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
O. A. Fedorova, A. N. Arkhipova, P. A. Panchenko, J. Berthet, S. Delbaere, S. Minkovska, Yu. V. Fedorov
Summary: The study introduces a photochromic supramolecular complex with benzopyran and a fluorescent compound, demonstrating that the presence of the fluorophore can significantly increase the bleaching rate compared to free benzopyran at room temperature. Varying the components in the supramolecular complex is preferable for obtaining desired characteristics in the system.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Oncology
Hideki Kashiwagi, Yoshihide Hattori, Shinji Kawabata, Ryo Kayama, Kohei Yoshimura, Yusuke Fukuo, Takuya Kanemitsu, Hiroyuki Shiba, Ryo Hiramatsu, Toshihiro Takami, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Mitsunori Kirihata, Masahiko Wanibuchi
Summary: In recent years, boron neutron capture therapy (BNCT) has been studied as a potential treatment for high-grade gliomas. In this study, the feasibility of using a boron compound, DPA-BSTPG, targeting the 18 kDa translocator protein (TSPO), was investigated. The results showed that BNCT using a combination of DPA-BSTPG and BPA could provide multi-targeted neutron capture therapy, leading to longer survival times in experimental glioma models.
Article
Materials Science, Multidisciplinary
L. B. O. Davi, D. J. P. Lima, C. D. A. E. S. Barbosa
Summary: This study successfully synthesized carbon dots with tricolor emission, which can be used for the production of high-quality white-light emitting diode devices.
Article
Chemistry, Medicinal
Arian Perez Nario, Jenilee Woodfield, Sofia Nascimento dos Santos, Cody Bergman, Melinda Wuest, Yasniel Babi Araujo, Andre Luis Lapolli, Frederick G. West, Frank Wuest, Emerson Soares Bernardes
Summary: Tissue hypoxia is a pathological condition commonly observed in solid tumors. Non-invasive imaging techniques like PET are important for detecting and monitoring tissue hypoxia changes.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2022)
Review
Oncology
Umberto Tosi, Omri Maayan, Anjile An, Miguel E. Tusa Lavieri, Sergio W. Guadix, Antonio P. DeRosa, Paul J. Christos, Susan Pannullo, Philip E. Stieg, Andrew Brandmaier, Jonathan P. S. Knisely, Rohan Ramakrishna
Summary: Treatment of NF2-associated vestibular schwannomas remains challenging, as stereotactic radiosurgery results in impaired hearing and worse cranial nerve comorbidities.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antonio D'Alessio, Claudia Angela Maria Fulgenzi, Naoshi Nishida, Martin Schoenlein, Johann von Felden, Kornelius Schulze, Henning Wege, Vincent E. Gaillard, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Nicola Personeni, Tiziana Pressiani, Rohini Sharma, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato
Summary: This study confirms the reproducible safety and efficacy of AtezoBev in routine clinical practice. Patients with impaired liver function (CP-B) showed comparable tolerability to those with normal liver function (CP-A), indicating the need for prospective evaluation in this specific population.
Article
Oncology
Claudia Angela Maria Fulgenzi, Jaekyung Cheon, Antonio D'Alessio, Naoshi Nishida, Celina Ang, Thomas U. Marron, Linda Wu, Anwaar Saeed, Brooke Wietharn, Antonella Cammarota, Tiziana Pressiani, Nicola Personeni, Matthias Pinter, Bernhard Scheiner, Lorenz Balcar, Andrea Napolitano, Yi-Hsiang Huang, Samuel Phen, Abdul Rafeh Naqash, Caterina Vivaldi, Francesca Salani, Gianluca Masi, Dominik Bettinger, Arndt Vogel, Martin Schoenlein, Johann von Felden, Kornelius Schulze, Henning Wege, Peter R. Galle, Masatoshi Kudo, Lorenza Rimassa, Amit G. Singal, Rohini Sharma, Alessio Cortellini, Vincent E. Gaillard, Hong Jae Chon, David James Pinato
Summary: This study confirms the reproducible safety and efficacy of atezolizumab plus bevacizumab in routine clinical practice for patients with unresectable hepatocellular carcinoma. The presence of portal vein tumor thrombosis (PVTT) and higher ALBI grade are indicators of poorer survival in patients who meet the Child-Pugh-A criteria.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Antonio D'Alessio, Claudia A. M. Fulgenzi, Naoshi Nishida, Martin Schoenlein, Johann von Felden, Kornelius Schulze, Henning Wege, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Nicola Personeni, Tiziana Pressiani, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato, Rohini Sharma
Summary: This study investigated the efficacy and safety of combination therapy with atezolizumab and bevacizumab in older patients with hepatocellular carcinoma. The results showed that there were no significant differences in treatment outcomes and safety between older and younger patients.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Yue Linda Wu, Claudia Angela Maria Fulgenzi, Antonio D'Alessio, Jaekyung Cheon, Naoshi Nishida, Anwaar Saeed, Brooke Wietharn, Antonella Cammarota, Tiziana Pressiani, Nicola Personeni, Matthias Pinter, Bernhard Scheiner, Lorenz Balcar, Yi-Hsiang Huang, Samuel Phen, Abdul Rafeh Naqash, Caterina Vivaldi, Francesca Salani, Gianluca Masi, Dominik Bettinger, Arndt Vogel, Martin Schoenlein, Johann von Felden, Kornelius Schulze, Henning Wege, Peter R. Galle, Masatoshi Kudo, Lorenza Rimassa, Amit G. Singal, Rohini Sharma, Alessio Cortellini, Vincent E. Gaillard, Hong Jae Chon, David J. Pinato, Celina Ang
Summary: Immunotherapy is the standard front-line therapy for advanced hepatocellular carcinoma, but many patients do not respond to it. This study evaluated the prognostic value of blood-based markers of inflammation and found that they may predict survival outcomes in patients treated with immunotherapy.
Article
Oncology
Y. Linda Wu, Grace van Hyfte, Umut Ozbek, Marlene Reincke, Anuhya Gampa, Yehia I. Mohamed, Naoshi Nishida, Brooke Wietharn, Suneetha Amara, Pei-Chang Lee, Bernhard Scheiner, Lorenz Balcar, Matthias Pinter, Arndt Vogel, Arndt Weinmann, Anwaar Saeed, Anjana Pillai, Lorenza Rimassa, Abdul Rafeh Naqash, Mahvish Muzaffar, Yi-Hsiang Huang, Ahmed O. Kaseb, Masatoshi Kudo, David J. Pinato, Celina Ang
Summary: Beta blocker use was not associated with overall survival, progression-free survival, or objective response rate in patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Clinical Neurology
Umberto Tosi, Mark Souweidane
Summary: Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a very poor prognosis, and the available therapeutic options have been limited for many years. However, recent advances in tissue availability and our understanding of tumor biology have led to the development of new therapeutic targets and experimental treatment strategies.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Umberto Tosi, Sergio W. Guadix, Mark M. Souweidane
Summary: Neuroendoscopy has become a mainstay in neurosurgical practice, allowing for minimally invasive approaches. However, challenges remain in terms of hemostasis and resection of large masses. New optics have improved image quality, but open craniotomy is still commonly used. The limited utilization of neuroendoscopy presents ongoing challenges for teaching and achieving technical mastery in neurosurgery.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Umberto Tosi, Mark M. Souweidane
Summary: Neuroendoscopy has made remarkable progress in recent decades, becoming a routine practice in neurosurgical treatment. However, the field still faces challenges and obstacles, but there are also many new directions of development.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Umberto Tosi, Sergio W. Guadix, Alan R. Cohen, Mark M. Souweidane
Summary: Neuro-endoscopy, originating from ancient Egyptian rituals, promises a minimally invasive approach to the brain. After initial technical obstacles, the development and transformation of neuroendoscopy continued and it has now become a widely used and reliable surgical option for various complex pathologies.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Evan D. Bander, Joseph A. Carnevale, Umberto Tosi, Kyle J. Godfrey, Theodore H. Schwartz
Summary: The lateral transorbital approach (LTOA) is a minimally invasive surgical technique that provides direct access to the cavernous sinus. A retrospective study of CS lesions treated by LTOA showed successful outcomes in all six cases, with an average extent of resection of 64.6%. Improvement in preoperative cranial neuropathies was observed in half of the patients, and there were no new permanent cranial neuropathies. Only one patient had a vascular injury, which was repaired endovascularly without neurological deficits.
OPERATIVE NEUROSURGERY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Arlette A. Haidar-Montes, Giuseppe Prencipe, Mohammad El Khatib, Annunziata Mauro, Paolo Berardinelli, Umberto Tosi, Guy Wouters, Johannes Stockl, Valentina Russo, Barbara Barboni
TISSUE ENGINEERING PART A
(2023)
Article
Clinical Neurology
Umberto Tosi, Alexander Ramos, Margherita Rampichini, George Alexiades, Srikanth Boddu, Babacar Cisse, Ashutosh Kacker, Athos Patsalides, Abtin Tabaee, Justin Schwarz, Theodore H. Schwartz, Rohan Ramakrishna
Summary: This study aimed to determine the feasibility of venous sinus stenting (VSS) as a treatment for symptoms relief and prevention of recurrence after surgical repair of skull base encephaloceles. The results showed that performing VSS within weeks of surgery can safely alleviate symptoms, resolve underlying pathology, and prevent CSF leak recurrence.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Umberto Tosi, Alexandra Giantini-Larsen, Dimitrios Mathios, Ashutosh Kacker, Vijay K. Anand, Kiarash Ferdowssian, Ali Baaj, Roger Hartl, Benjamin I. Rapoport, Jeffrey P. Greenfield, Theodore H. Schwartz
Summary: This study reviewed the clinical data of a large number of patients who underwent EEO surgery and found that EEO surgery is safe and effective, improving patients' symptoms. Complications associated with posterior cervical fusion were rare.
JOURNAL OF NEUROSURGERY
(2023)
Meeting Abstract
Psychology, Clinical
Heidi Bender, Evan Bander, Alice Gavarrete-Olvera, Julia Giambrone, Kseniya Katsman, Samer Muhareb, Kate Rosen, Amanda Sacks-Zimmerman, Madison Seger, Mark Souweudane, Umberto Tosi, David L. Yap
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
