Article
Cell Biology
Elzbieta Rutkowska, Iwona Kwiecien, Joanna Bednarek, Rafal Sokolowski, Agata Raniszewska, Karina Jahnz-Rozyk, Piotr Rzepecki
Summary: This study revealed that the proportion of T lymphocytes, CD4+ T cells, and CD8+ T cells were lower in patients with Sarcoidosis (SA) and DLCO below 80% compared to those with normal diffusion (DLCO > 80%). Furthermore, patients with DLCO lower than 80% had a lower proportion of effector cells and a higher proportion of central memory CD4+ and CD8+ T cells in lymph nodes, indicating a unique maturation profile in SA patients with lower DLCO values.
Article
Engineering, Biomedical
Chaoyi Wu, Feng Chang, Xiao Su, Zhihan Wu, Yanfeng Wang, Ling Zhu, Ya Zhang
Summary: Metastasis on lymph nodes is a common way for primary tumor cells to spread, but detecting metastatic lymph nodes is challenging for radiologists. This study introduces an additional branch that utilizes information about lymph node stations for supplementary detection, using a GCN-based structure to model the relationship among different lymph node stations and achieving better performance in metastatic LN detection.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2022)
Article
Multidisciplinary Sciences
Maja Guberina, Ken Herrmann, Christoph Poettgen, Nika Guberina, Hubertus Hautzel, Thomas Gauler, Till Ploenes, Lale Umutlu, Axel Wetter, Dirk Theegarten, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Metzenmacher, Marcel Wiesweg, Martin Schuler, Ruediger Karpf-Wissel, Alina Santiago Garcia, Kaid Darwiche, Martin Stuschke
Summary: This study aimed to predict lymph node involvement in non-small cell lung cancer patients using machine learning models, and the results showed that PET/CT-based machine learning classifiers can achieve high sensitivity to detect lymph node involvement at a low misclassification rate.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Zhe-Wu Jin, Masaya Aoki, Kazuhiro Ueda, Go Kamimura, Aya Takeda-Harada, Gen Murakami, Masami Sato
Summary: Lymph node degeneration was examined in 539 nodes from 78 patients without cancer metastasis. The study found medullary sinus hyalinization and subcapsular sinus hyalinization in the nodes. These degenerative lesions were not correlated with age or smoking.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maribel Botana-Rial, Irene Lojo-Rodriguez, Virginia Leiro-Fernandez, Cristina Ramos-Hernandez, Almudena Gonzalez-Montaos, Luis Pazos-Area, Manuel Nunez-Delgado, Alberto Fernandez-Villar
Summary: CryoEBUS has shown higher diagnostic usefulness compared to EBUS-TBNA for mediastinal and hilar involvement, especially in cases of benign pathologies and other tumor types such as lymphomas. Samples obtained by cryoEBUS also allow for better histological subtyping of lymphoma and complete molecular characterization in cases of lung cancer.
RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Cedric Raymond, Arthur Vieira, Philippe Joubert, Paula A. Ugalde
Summary: Evaluation of lymph nodes is crucial for lung cancer resection in order to determine the stage and treatment decisions. We have developed a standardized approach to improve the classification of lymph nodes in the hilum and periphery. This method, when combined with mediastinal lymph node dissection, maximizes the accuracy of pathologic classification.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Zhouzhou Bao, Binge Deng, Yuqing Zhang, Xiaowei Li, Ziyang Tan, Zhuowei Gu, Bobo Gu, Zhifeng Shao, Wen Di, Jian Ye
Summary: A new approach using Raman imaging and data processing has been developed for rapid and accurate diagnosis of metastatic SLN during surgery, achieving an accuracy of 87.5%, which may outperform the existing histopathological assessment method.
Article
Multidisciplinary Sciences
Shozo Yokoyama, Takashi Watanabe, Yoichi Fujita, Shuichi Matsumura, Katsuya Ueda, Shotaro Nagano, Ikuharu Kinoshita, Daisuke Murakami, Hirotaka Tabata, Toshiaki Tsuji, Satoru Ozawa, Takuya Tamaki, Yoshihiro Nakatani, Masami Oka
Summary: This study investigated the histologies of lymph node metastasis (LNM) in 119 patients with colorectal cancer (CRC) and found that the LNM histologies showed heterogeneity. The study also found that the histology in LNM was associated with the differentiation of the primary tumor and prognosis in CRC patients.
Review
Immunology
Jihoon Kim, Paul A. Archer, Susan N. Thomas
Summary: Lymph nodes are secondary lymphoid tissues involved in immune cell interaction and related to various diseases. Nanotechnologies hold potential in biomedical applications, particularly in relation to lymph nodes. Consideration of lymph node tissue structure, lymphatic system physiology, and delivery mechanisms is crucial for designing nanocarriers for lymph node delivery.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Article
Biochemistry & Molecular Biology
Lionel Gillot, Alizee Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durre, Remi Longuespee, Gabriel Mazzucchelli, Christophe Nizet, Silvia Blacher, Frederic Kridelka, Agnes Noel
Summary: This study revealed an association between POSTN deposition and lymphangiogenesis in lymph nodes of cervical cancer patients, highlighting the key role of POSTN in promoting lymphatic vessel formation and the seeding of metastatic cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Asghar Naqvi, Michael Bonert, Christian Finley, Katarzyna Czarnecka-Kujawa, Kazuhiro Yasufuku, Joerg Schwock, Vathany Kulasingam, Rohan John, Hyang-Mi Ko
Summary: The utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for the diagnosis of amyloidosis, including when clinically unsuspected, and the feasibility of subsequent mass spectrometry (MS) for subtyping of the amyloidogenic protein were investigated. EBUS-TBNA/EUS-FNA was able to provide an early and accurate assessment of unexpected mass-like deposits of nodal amyloid with sufficient material to diagnose and classify the protein subtype.
CANCER CYTOPATHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manus J. Donahue, Paula M. C. Donahue, R. Sky Jones, Maria Garza, Chelsea Lee, Niral J. Patel, Andrea Cooper, Jill B. De Vis, Ingrid Meszoely, Rachelle Crescenzi
Summary: This study investigates whether in vivo imaging with CEST-Dixon can distinguish lymph nodes with metastatic involvement from those without. The results suggest that CEST-Dixon can detect a unique microenvironment in metastatic lymph nodes and has the potential for non-invasive mapping of lymph node metastasis in vivo.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Immunology
Gregory P. Howard, Nicole G. Bender, Prachi Khare, Borja Lopez-Gutierrez, Vincent Nyasembe, William J. Weiss, Jerry W. Simecka, Timothy Hamerly, Hai-Quan Mao, Rhoel R. Dinglasan
Summary: This study developed a nanoparticle-based malaria transmission blocking vaccine that successfully induced an immune response blocking parasite transmission by co-delivering UF6b and CpG oligodeoxynucleotide immunostimulatory sequence 1018. This nanovaccine platform allows for antigen dose-sparing and achieves immunopotentiation of AnAPN1 through direct lymph node targeting.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Seungbum Wi, Bo-Guen Kim, Sun Hye Shin, Byung Woo Jhun, Hongseok Yoo, Byeong-Ho Jeong, Kyungjong Lee, Hojoong Kim, O. Jung Kwon, Joungho Han, Jhingook Kim, Sang-Won Um
Summary: This study assessed the clinical utility of EBUS-TBNA for station 10/11/12 lymph nodes in patients with primary lung cancer. The overall diagnostic sensitivity, specificity, and accuracy of EBUS-TBNA were high, with better performance for LNs >=10 mm in size. There was no significant difference in diagnostic performance based on nodal station or left-right location.
Article
Infectious Diseases
Shinya Otsuka, Kei Hiraoka, Masato Suzuoki, Hideki Ujiie, Tatsuya Kato, Isao Yokota, Kazuya Yonezawa, Keiji Oguma, Nozomu Iwashiro, Mototsugu Kato, Masanori Ohara
Summary: This study demonstrates the significant contribution of the BNT162b2 vaccine in acquiring anti-SARS-CoV-2S antibodies, and these two vaccine doses are expected to provide protection for at least five months. Despite the risk of infection, vaccinated individuals did not develop breakthrough infections.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Respiratory System
Ryohei Chiba, Yuma Ebihara, Haruhiko Shiiya, Hideki Ujiie, Aki Fujiwara-Kuroda, Kichizo Kaga, Liming Li, Satoru Wakasa, Satoshi Hirano, Tatsuya Kato
Summary: This study investigated the usefulness of a novel fluorescence spectroscopy system in tumor localization. The results showed that the system could identify tumors at depths greater than or equal to 15 mm, and could detect tumors at greater depths with lower density intervening material.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Respiratory System
Haruhiko Shiiya, Akihiko Tanaka, Motoki Sakuraba, Hideki Ujiie, Tatsuya Kato
Summary: Parietal pleural small holes (PPSHs) are commonly found during surgery for spontaneous pneumothorax, especially in patients with primary spontaneous pneumothorax (PSP). Patients with PPSHs also tend to have a mild chest wall flatness compared to those without PPSHs. Understanding PPSHs may contribute to a better understanding of PSP.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Surgery
Yuya Wada, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
Summary: Flap bronchoplasty using c-VATS is a valuable technique for preserving lung function with minimal invasiveness and cosmetic advantages in the treatment of primary bronchial tumors.
VIDEO-ASSISTED THORACIC SURGERY
(2022)
Article
Chemistry, Multidisciplinary
David Chapron, Juan Chen, Gang Zheng, Veronique Rosilio
Summary: Photodynamic therapies combine the action of a photosensitizer, molecular oxygen, and light to destroy infectious sites and tumors. Incorporating photosensitizers in nanocarriers allows better control of their distribution in tissues and increases concentration in the illuminated area. This study highlights the importance of characterizing the interfacial properties of porphyrin derivatives and their interaction with the oil to design stable nanoemulsions with well-controlled optical properties.
Article
Respiratory System
Huda Asif, Franck F. Rahaghi, Akihiro Ohsumi, Julie Philley, Amir Emtiazjoo, Takashi Hirama, Arthur W. Baker, Chin-Chung Shu, Fernanda Silveira, Vincent Poulin, Pete Rizzuto, Miki Nagao, Pierre-Regis Burgel, Steve Hays, Timothy Aksamit, Takeshi Kawasaki, Charles Dela Cruz, Stefano Aliberti, Takahiro Nakajima, Stephen Ruoss, Theodore K. Marras, Gregory Snell, Kevin Winthrop, Mehdi Mirsaeidi
Summary: This study provides essential recommendations for the management of nontuberculous mycobacterial infections in lung transplant candidates. The recommendations cover screening methods, contraindications for surgery, and treatment options. These recommendations can serve as expert opinions for clinicians until more evidence-based contributions are available.
Article
Pharmacology & Pharmacy
Keegan Guidolin, Lili Ding, Juan Chen, Gang Zheng
Summary: This study aims to develop a clinically viable protocol for nanoparticle-based photodynamic therapy (PDT) in the treatment of colorectal cancer. The study finds that nanoparticle-based PDT effectively ablates colorectal cancer tumors, can be delivered after a relatively short drug-light interval (DLI), and safety concerns can be mitigated through specific delivery methods. These findings lay the foundation for future clinical trials investigating the use of PDT as a component of multi-modal approaches to treat colorectal cancer.
ADVANCED THERAPEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Marta Overchuk, Robert A. Weersink, Brian C. Wilson, Gang Zheng
Summary: Tumoricidal photodynamic (PDT) and photo-thermal (PTT) therapies use light to eliminate cancer cells with precision. The combination of PDT and PTT shows potential due to their different mechanisms of action. Recent developments in multimodal nanoparticles further enhance their efficacy. This review discusses the limitations of each modality alone and how combining them can improve treatment efficacy and safety. It also analyzes the design strategies of dual PDT/PTT nanoparticles and the impact of treatment sequence and dose on treatment response. Additionally, it provides guidelines to elucidate the mechanisms underlying PDT/PTT interactions.
Article
Chemistry, Multidisciplinary
Yulin Mo, Miffy H. Y. Cheng, Andrew D'Elia, Katie Doran, Lili Ding, Juan Chen, Pieter R. Cullis, Gang Zheng
Summary: A strategy called LASER was developed to achieve siRNA release within cells by activating the molecules within lipid nanoparticles using laser light. This approach improved the effectiveness of gene therapy.
Editorial Material
Biochemical Research Methods
Goncalo J. L. Bernardes, Peng Zou, Zhifei Dai, Erin Lavik, Jan van Hest, Gang Zheng, Nathan Quinn, Christina M. MacLaughlin, Theresa M. Reineke
BIOCONJUGATE CHEMISTRY
(2023)
Article
Health Care Sciences & Services
Kota Ohashi, Hidemi Suzuki, Yuki Sata, Kazuhisa Tanaka, Takayoshi Yamamoto, Yuichi Sakairi, Hironobu Wada, Takahiro Nakajima, Natsuko Nozaki-Taguchi, Shiroh Isono, Yuki Shiko, Yohei Kawasaki, Ichiro Yoshino
Summary: This study aimed to identify the factors associated with postoperative pain, quality of life, and development of chronic pain after lung cancer surgery. The results showed that individual pain sensation threshold and fentanyl sensitivity were not significantly associated with postoperative pain scores, quality of life scores, or the incidence of post-thoracotomy pain syndrome.
ANNALS OF PALLIATIVE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Huitao Wang, Kohei Shikano, Takahiro Nakajima, Yukihiro Nomura, Toshiya Nakaguchi
Summary: Lung cancer is the second most common cancer with a low survival rate. Endobronchial ultrasonography (EBUS) images have been increasingly used in diagnosing lung cancer due to their real-time performance and no radiation. This research aims to develop a computer-aided diagnosis (CAD) system for differentiating benign and malignant peripheral pulmonary lesions (PPLs). The experimental results show that the developed CAD system has the potential ability to diagnose PPLs using EBUS images based on Deep Learning.
APPLIED SCIENCES-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Giulia Kassab, Neha Manav, Layla Pires, Miffy H. Y. Cheng, Yulin Mo, Hilde H. Buzza, Iti Gupta, Juan Chen, Gang Zheng
Summary: This study presents an improved photosensitizer system for antimicrobial photodynamic therapy (aPDT) by adjusting the structural components and compounds. The incorporation of higher cholesterol and PEG-lipid in the formulations enhances the potency against Staphylococcus aureus. Ethylenediaminetetraacetic acid (EDTA)-lipid significantly enhances aPDT efficacy but also increases toxicity toward host cells. Introducing the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) improves interaction with bacteria but negatively impacts stability.
Article
Chemistry, Multidisciplinary
Maneesha A. Rajora, Alexander Dhaliwal, Mark Zheng, Victor Choi, Marta Overchuk, Jenny W. H. Lou, Carly Pellow, David Goertz, Juan Chen, Gang Zheng
Summary: Microbubble-enabled focused ultrasound has revolutionized drug delivery capabilities, but the lack of systematic studies on microbubble shell pharmacokinetics hinders progress in the field. This study develops a method to radiolabel microbubbles and investigates the impact of microbubble composition and ultrasound on drug delivery. The findings provide insights into the design and safety of the microbubble platform.
Article
Cardiac & Cardiovascular Systems
Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Satoru Wakasa, Setsuyuki Otake, Keisuke Kikuchi, Koichi Ohno
Summary: Thymoma accompanied by SPS, a rare case, was successfully treated with surgery. No evidence of recurrence was observed over 44 months.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
