Article
Cell Biology
Wei Yang, Yan Xiang, Mao-Jun Liao, Peng-Fei Wu, Lin Yang, Guo-Hao Huang, Bao-Zhong Shi, Liang Yi, Sheng-Qing Lv
Summary: The study reveals that Presenilin1 represses migration, invasion, and mesenchymal transition of glioblastoma cells, interacts with Sortilin, and regulates phosphorylation of beta-catenin. Overall, Sortilin mediates the anti-invasive function of Presenilin1.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Alanah Varricchio, Sunita A. Ramesh, Andrea J. Yool
Summary: Glioblastoma multiforme is a leading cause of brain cancer-related deaths worldwide, with cells capable of infiltrating healthy brain tissue rapidly. Targeting cellular motility pathways may help slow tumor dispersal and provide a longer time window for frontline treatments. Expressions of Aquaporins (AQPs) and voltage-gated ion channels in GBM cells could be pharmacological targets to restrain cell migration, potentially enhancing therapeutic effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jose Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martinez, Angelo Torres, Rody San Martin, Juan Carlos Roa, Claudia Quezada-Monras
Summary: Glioblastoma (GBM) is a common and malignant brain cancer with poor prognosis. Its low effectiveness is attributed to tumor infiltration into healthy brain tissue, which depends on the interaction between GBM cells and the tumor microenvironment (TME). This review highlights the use of 3D patient-derived glioblastoma organoid cultures as a new platform for studying TME and invasiveness. It discusses the mechanisms involved in GBM-TME interaction and proposes potential prognostic biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Lauren Dzikowski, Reza Mirzaei, Susobhan Sarkar, Mehul Kumar, Pinaki Bose, Anita Bellail, Chunhai Hao, V. Wee Yong
Summary: The study investigated the expression of ECM molecules in GBM patients, the effects of different ECM molecules on BTICs in culture, and the association between ECM molecules and MMP-2 and -9 in resected GBM specimens.
Article
Cell Biology
Gopinath Kulasekaran, Mathilde Chaineau, Valerio Emilio Crescenzo Piscopo, Federica Verginelli, Maryam Fotouhi, Martine Girard, Yeman Tang, Rola Dali, Rita Lo, Stefano Stifani, Peter S. McPherson
Summary: The study demonstrated that loss of function of the endosomal GTPase Rab35 in human brain tumor initiating cells increases glioblastoma growth and decreases animal survival. Mechanistically, the GTPase Arf5 enhances its GEF activity toward Rab35, resulting in increased growth and invasiveness of BTIC-initiated brain tumors.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Neurosciences
Helena Marcelino, Tiago M. A. Carvalho, Joana Tomas, Francisca Teles, Ana C. Honorio, Carolina B. Rosa, Ana R. Costa, Bruno M. Costa, Cecilia R. A. Santos, Ana M. Sebastiao, Jose F. Cascalheira
Summary: The study found that the inhibitory effect of adenosine on glioblastoma multiforme (GBM) cells is significantly weakened, possibly due to increased adenosine elimination by adenosine kinase. Additionally, adenosine also enhances the cytotoxic effect of homocysteine on human astrocytes.
Article
Cell Biology
Yaotian Hu, Zhiyi Xue, Chen Qiu, Zichao Feng, Qichao Qi, Jiwei Wang, Wenxing Jin, Zhaoyang Zhong, Xiaofei Liu, Wenjie Li, Qing Zhang, Bin Huang, Anjing Chen, Jian Wang, Ning Yang, Wenjing Zhou
Summary: NUSAP1 is significantly upregulated in human glioblastoma (GBM) and its high expression is associated with poor patient survival. Knockdown of NUSAP1 inhibits GBM cell proliferation and invasion, and induces cell apoptosis, suggesting that NUSAP1 may serve as a promising molecular target for GBM treatment.
Article
Pathology
Fanen Yuan, Qian Sun, Yang Xu, Huikai Zhang, Gang Deng, Jian Yang, Shenqi Zhang, Junhui Liu, Baohui Liu, Qianxue Chen
Summary: CircRNAs are increasingly recognized for their roles in glioblastoma (GBM), with hsa_circ_0072309 showing significant downregulation in GBM and inhibiting cell proliferation and invasion in this context. The interaction of hsa_circ_0072309 with HSP27 highlights its potential as a therapeutic target for comprehensive treatment of GBM.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong-Gang Wang, Amir Sheikhi, James R. Connor
Summary: This study found that increasing cellular iron content decreased migratory capacity of human glioblastoma cells, and cells with higher iron levels exhibited reduced motility. Cells at the tumor periphery had a gene signature consistent with lower levels of cellular iron.
Article
Biochemistry & Molecular Biology
Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong-Gang Wang, Amir Sheikhi, James R. Connor
Summary: Cellular iron content has an impact on the migratory capacity of glioblastoma cells, with higher iron levels leading to reduced motility. This finding is crucial for understanding the migration and invasion mechanisms of glioblastoma.
Article
Biochemistry & Molecular Biology
Changwang Du, Taoning Wang, Jinning Jia, Junjun Li, Yi Xiao, Jia Wang, Ping Mao, Ning Wang, Luoning Shi, Maode Wang
Summary: This study found that the expression of RPL34 in glioblastoma is associated with poor prognosis and is required for tumor proliferation. Mechanically, inhibition of RPL34 induces glioma cell apoptosis through the activation of the Bad/Caspase7/PARP signaling pathway.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao, Xingchun Gou
Summary: The study showed that CACUL1 overexpression in glioma tissues promoted cell proliferation, suppressed apoptosis, and induced cell cycle arrest. Knockdown of CACUL1 hindered cell proliferation and induced apoptosis in glioblastoma cells, suggesting a potential oncogenic role for CACUL1 in gliomas.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Clinical Neurology
Li Liu, Li Jia, Jun Shao, Hanhua Liu, Qinke Wu, Xudong Wu
Summary: The study revealed that circNF1 is upregulated in glioblastoma and inhibits cell proliferation by promoting the maturation of miR-340, providing further insights into its potential role in tumors.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Rebeca E. Nunez, Miguel Mayol del Valle, Kyle Ortiz, Luis Almodovar, Lilia Kucheryavykh
Summary: Microglia play a crucial role in glioma progression, with PDGF beta, SDF-1 alpha, IL-6, IL-8, and EGF identified as key factors in activating Pyk2 and FAK in glioma cells. Microglia-released EGF, PDGF beta, and SDF-1 alpha were found to promote invadopodia formation and cell migration in a Pyk2- and FAK-dependent manner, while EGF and IL-6 were shown to regulate cell viability and mitosis through Pyk2 and FAK signaling.
Article
Medicine, Research & Experimental
Yu-Ge Zhu, Yun-Xia Lv, Chen-Yi Guo, Zhi-Min Xiao, Qun-Guang Jiang, Huang Kuang, Wen-Hua Zhang, Ping Hu
Summary: The study demonstrates that harmine significantly inhibits the proliferation and migration of U251-MG and U373-MG cells by suppressing the FAK/AKT signaling pathway. These results suggest that harmine could be a promising drug for glioblastoma therapy.
Article
Chemistry, Multidisciplinary
Joanna Kwiczak-Yigitbasi, Jean-Luc Pirat, David Virieux, Jean-Noel Volle, Agnieszka Janiak, Marcin Hoffmann, Donata Pluskota-Karwatka
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Organic
Rachida Babouri, Lancine Traore, Yves-Alain Bekro, Victoria I. Matveeya, Yulia M. Sadykova, Julia K. Voronina, Alexander R. Burilov, Tahar Ayad, Jean-Noel Volle, David Virieux, Jean-Luc Piratt
Review
Chemistry, Organic
Tahar Ayad, Aurelie Gernet, Jean-Luc Pirat, David Virieux
Article
Chemistry, Organic
Mina Hariri, Fatemeh Darvish, Karen-Pacelye Mengue Me Ndong, Nora Sechet, Geraud Chacktas, Hooriye Boosaliki, Minh Loan Tran Do, Gabin Mwande-Maguene, Jacques Lebibi, Alexander R. Burilov, Tahar Ayad, David Virieux, Jean-Luc Pirat
Summary: This study presents a straightforward synthesis of phosphorus-based heterocycles, 2-phenyl 1H-isophosphinoline 2-oxides 1, using a gold(I) catalyzed reaction with electron-poor alkynes. The reaction, conducted under microwave activation with PPh3AuCl precatalyst and triflic acid, resulted in moderate to quantitative yields of isophosphinoline 2-oxides 1 through a regioselective 6-endo-dig hydroarylation cyclization, demonstrating a promising approach for the synthesis of phosphorus heterocycles.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
David Virieux, Francesco Delogu, Andrea Porcheddu, Felipe Garcia, Evelina Colacino
Summary: Molecular rearrangements using mechanochemistry are a powerful tool to construct complex structures in a sustainable manner, particularly for preparing active pharmaceutical ingredients and natural products. This approach, although still in its early stages, holds promise for chemists to merge molecular diversity and green chemistry perspectives towards more selective and efficient syntheses.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Lucas Mele, Jean Luc Pirat, Tahar Ayad, David Virieux
Summary: This comprehensive review summarizes the significant progress made in the synthesis of alkynylphosphorus compounds over the past 20 years. It focuses on sustainable catalysis or direct metal-free couplings from stable precursors. The review provides detailed insights into recent advancements and mechanisms of metal-catalyzed reactions, photocatalytic reactions, and metal-free reactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Kmar Abaid, William Erb, David Virieux, Laurent Picot, Benjamin Musnier, Valerie Thiery, Thierry Roisnel, Florence Mongin, Soufiane Touil
Summary: An efficient and simple method was developed for the synthesis of unprecedented 4,5-diphosphonyldihydropyridazines and 3,4-diphosphonylpyrroles. The reactions proceeded under operationally simple, mild, and catalyst-free conditions, and showed promising growth inhibition against melanoma cancer cells.
Article
Chemistry, Multidisciplinary
Aija Trimdale-Deksne, Artis Kons, Liana Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Liliana Mazur, Magdalena Skiba, Marta K. Dudek, Nicolas Fantozzi, David Virieux, Evelina Colacino, Agris Berzins
Summary: This study investigates the factors contributing to the formation of polymorphs, hydrates, solvates, and solvate hydrates in three hydantoin-based active pharmaceutical ingredients-nitrofurantoin, furazidin, and dantrolene. Crystallographic and computational analysis of the crystal structures of these compounds reveals differences in their hydrogen bonding patterns and packing features, which correlate with their propensity to form solvates and solvate hydrates. The stability of the hydrate phases also plays a role in the differences observed.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Lucas Mele, Rachida Babouri, Jean-Luc Pirat, Eder Tomas-Mendivil, David Martin, Tahar Ayad, David Virieux
Summary: In the past 30 years, researchers have shown great interest in synthesizing atropochiral biaryls with steric congestion on the ortho-substituted arenes. This study presents an efficient approach to produce a new class of 2,2' disubstituted biaryls bridgehead phosphine oxides with exceptional conformational stability. The researchers found that by replacing only one hydrogen atom at the ortho position with a fluorine atom, the rotation of the biaryl backbone can be restricted at temperatures below 80°C, significantly extending the limits of atropostability. Additionally, their investigations revealed unique insights into the isomerization mechanism of these molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Nicolas Fantozzi, Jean-Noel Volle, Andrea Porcheddu, David Virieux, Felipe Garcia, Evelina Colacino
Summary: This article highlights the significance of green chemistry methods for promoting sustainable development, with a focus on batch and continuous mechanochemical methods in organic synthesis. The environmentally-friendly aspects of these methods are objectively assessed using green metrics and indicators, providing a comprehensive evaluation of their greenness. The article also provides an introduction to the topic, discusses variables influencing reaction outcomes, and offers an outlook for future research in this field.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lucas Mele, Raphael El Bekri Saudain, Jean-Luc Pirat, David Virieux, Tahar Ayad
Summary: A simple and rapid microwave-assisted protocol for the selective alkaline hydrolysis of phosphonate diesters has been developed, allowing efficient access to a wide variety of diversely substituted phosphonic acid monoesters. Conventional approaches struggle to obtain such compounds.
Article
Chemistry, Inorganic & Nuclear
Andrea Deak, Csaba Jobbagy, Attila Demeter, Ladislav Celko, Jaroslav Cihlar, Pal T. Szabo, Peter Abranyi-Balogh, Deborah E. Crawford, David Virieux, Evelina Colacino
Summary: A mechanochemical method was used to synthesize Au(diphos)X complexes with different luminescent colors, which can undergo reversible color changes under mechanical stimulus or solvent vapor influence. These results demonstrate the efficient and environmentally friendly synthesis of luminescent gold(I) complexes using mechanochemistry.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Organic
Aurelie Gernet, Nicolas Sevrain, Jean-Noel Volle, Tahar Ayad, Jean-Luc Pirat, David Virieux
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Aurelie Gernet, Virginie Ratovelomanana-Vidal, Jean-Luc Pirat, David Virieux, Tahar Ayad
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Joanna Kwiczak-Yigitbasi, Jean-Luc Pirat, David Virieux, Jean-Noel Volle, Agnieszka Janiak, Marcin Hoffmann, Jakub Mrzyglod, Dariusz Wawrzyniak, Jan Barciszewski, Donata Pluskota-Karwatka