Individual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

(2016) Tiziano Dallavilla et al.   PLoS Computational Biology

Critical role of evolutionarily conserved glycosylation at Asn211in the intracellular trafficking and activity of sialyltransferase ST3Gal-II

(2015) Fernando M. Ruggiero et al.   BIOCHEMICAL JOURNAL

Enzymatic protein depalmitoylation by acyl protein thioesterases

(2015) David T.S. Lin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events

(2015) Lorena Agudo-Ibáñez et al.   MOLECULAR AND CELLULAR BIOLOGY

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

The role of palmitoylation in regulating Ras localization and function

(2013) Sharon Eisenberg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNAi screens in mice identify physiological regulators of oncogenic growth

(2013) Slobodan Beronja et al.   NATURE

2-Bromopalmitate Reduces Protein Deacylation by Inhibition of Acyl-Protein Thioesterase Enzymatic Activities

(2013) Maria P. Pedro et al.   PLoS One

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

(2011) J. Xu et al.   BLOOD

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation

(2011) Ian M. Ahearn et al.   MOLECULAR CELL

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

(2011) V. L. R. M. Verstraeten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

(2010) Vanesa M. Tomatis et al.   PLoS One

Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway

(2009) Alejandra Trenchi et al.   BIOCHEMICAL JOURNAL

Protein acyl thioesterases (Review)

(2009) Ruth Zeidman et al.   MOLECULAR MEMBRANE BIOLOGY

A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

(2008) Jamil Kanaani et al.   JOURNAL OF CELL SCIENCE

Similar Membrane Affinity of Mono- and Di-S-acylated Ras Membrane Anchors: A New Twist in the Role of Protein Lipidation

(2008) Alemayehu A. Gorfe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY