Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

Mechanisms of marrow adiposity and its implications for skeletal health

(2017) Annegreet G. Veldhuis-Vlug et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Geometry and network connectivity govern the mechanics of stress fibers

(2017) Elena Kassianidou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions

(2017) Ryuichi Watanabe et al.   Scientific Reports

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control

(2017) Kazunori Kume et al.   PLoS Genetics

Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation

(2016) Noam Zuela et al.   JOURNAL OF CELL SCIENCE

Nuclear constriction segregates mobile nuclear proteins away from chromatin

(2016) Jerome Irianto et al.   MOLECULAR BIOLOGY OF THE CELL

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

(2016) Giovanni Meacci et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

(2015) A. Gutierrez-Fernandez et al.   EMBO JOURNAL

The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions

(2015) H. E. Balcioglu et al.   JOURNAL OF CELL SCIENCE

The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts

(2015) S. G. Alam et al.   JOURNAL OF CELL SCIENCE

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

(2015) Nilesh P. Talele et al.   Stem Cell Reports

Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events

(2014) Haguy Wolfenson et al.   BIOPHYSICAL JOURNAL

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Osmotic Challenge Drives Rapid and Reversible Chromatin Condensation in Chondrocytes

(2013) Jerome Irianto et al.   BIOPHYSICAL JOURNAL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Proliferation and differentiation of mouse embryonic stem cells lacking all lamins

(2013) Youngjo Kim et al.   CELL RESEARCH

Mutations in LMNA Modulate the Lamin A - Nesprin-2 Interaction and Cause LINC Complex Alterations

(2013) Liu Yang et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

ENCODE Data in the UCSC Genome Browser: year 5 update

(2012) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Lamin B Receptor Regulates the Growth and Maturation of Myeloid Progenitors via its Sterol Reductase Domain: Implications for Cholesterol Biosynthesis in Regulating Myelopoiesis

(2011) G. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Post-natal myogenic and adipogenic developmental

(2011) Nard Kubben et al.   Nucleus

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

(2010) A. Buxboim et al.   JOURNAL OF CELL SCIENCE

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Ablation of Nonmuscle Myosin II-B and II-C Reveals a Role for Nonmuscle Myosin II in Cardiac Myocyte Karyokinesis

(2010) Xuefei Ma et al.   MOLECULAR BIOLOGY OF THE CELL

Optimal matrix rigidity for stress-fibre polarization in stem cells

(2010) A. Zemel et al.   Nature Physics

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels

(2008) F. Xavier Ruiz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Granulocytic nuclear differentiation of lamin B receptor–deficient mouse EPRO cells

(2008) Monika Zwerger et al.   EXPERIMENTAL HEMATOLOGY

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT