Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

The Sec61 translocon limits IRE1α signaling during the unfolded protein response

(2017) Arunkumar Sundaram et al.   eLife

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

A Eukaryotic Sensor for Membrane Lipid Saturation

(2016) Roberto Covino et al.   MOLECULAR CELL

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells

(2016) Yusuke Sekine et al.   PLoS One

Lipid-dependent regulation of the unfolded protein response

(2015) Romain Volmer et al.   CURRENT OPINION IN CELL BIOLOGY

Lipid–protein interactions

(2015) Anthony G. Lee   BIOCHEMICAL SOCIETY TRANSACTIONS

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

(2014) Carlotta Ronda et al.   BIOTECHNOLOGY AND BIOENGINEERING

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

(2013) Edward Avezov et al.   JOURNAL OF CELL BIOLOGY

A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress

(2013) Michal A. Surma et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

(2013) Thorsten Klampfl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

(2011) Alexei V Korennykh et al.   BMC BIOLOGY

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Regulation of human EGF receptor by lipids

(2011) U. Coskun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

(2010) Hayley J. Sharpe et al.   CELL

Membrane Thickness Cue for Cold Sensing in a Bacterium

(2010) Larisa E. Cybulski et al.   CURRENT BIOLOGY

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Lipid-Induced ER Stress by Fatty Acid Shape

(2010) Julie Deguil et al.   TRAFFIC

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids

(2009) Ludovic Pineau et al.   TRAFFIC

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE