Article
Immunology
Nimansha Jain, Caroline A. Lewis, Jason D. Ulrich, David M. Holtzman
Summary: Variants in the TREM2 gene are associated with increased risk for late-onset AD, and decreased function of TREM2 can affect microglial response to Aβ plaques. Chronic increase of TREM2 signaling may exacerbate the Aβ-induced tau pathology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Cell Biology
Jaakko Saraste, Kristian Prydz
Summary: This study explores the assembly of coronaviruses in the intermediate compartment at the ER-Golgi interface and their connection with the endocytic recycling system.
Article
Immunology
Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A. Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C. Ikezu, Zonghua Li, Axel D. Meneses, Yunjung Jin, Joshua A. Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L. Smith, Manling Xie, Yong U. Liu, Anthony D. Umpierre, Koichiro Haruwaka, Zachary S. Quicksall, Peter Storz, Yan W. Asmann, Long-Jun Wu, Guojun Bu
Summary: This study using mouse models demonstrates that overexpression of human TREM2 in microglia can reduce amyloid deposition and suppress disease-associated microglia in the early amyloid seeding stage, while the R47H variant exacerbates amyloid burden in the middle amyloid rapid growth stage. These findings highlight the dynamic effects of TREM2 in modulating AD pathogenesis and emphasize the beneficial effect of enhancing TREM2 function in the early stage of AD development.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Clinical Neurology
Yousuf Bakhit, Christelle O. Tesson, Mohamed Ibrahim, Khalid Eltom, Isra Eltazi, Liena E. O. Elsayed, Suzanne Lesage, Osheik Seidi, Jean-Christophe Corvol, Ullrich Wuellner
Summary: This study reported two cases of late-onset parkinsonism and identified PLA2G6 gene mutations associated with this condition for the first time. The findings suggest that PLA2G6 gene mutations may have a dual effect on the structure and function of iPLA2b.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Ankur Rakesh Dubey, Ribhav Mishra, Yuvraj Anandrao Jagtap, Sumit Kinger, Prashant Kumar, Rohan Dhiman, Somnath Ghosh, Sarika Singh, Amit Prasad, Nihar Ranjan Jana, Amit Mishra
Summary: Cells perform regular maintenance to avoid protein misfolding accumulation, which can lead to ageing-related diseases. Itraconazole treatment induces proteasome activities to degrade misfolded proteins, including those associated with neurodegenerative diseases. These findings suggest that Itraconazole has a potential therapeutic role in preventing protein misfolding neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Genetics & Heredity
Houda Belaghzal, Tyler Borrman, Andrew D. Stephens, Denis L. Lafontaine, Sergey V. Venev, Zhiping Weng, John F. Marko, Job Dekker
Summary: Liquid chromatin Hi-C technique reveals the stability of interactions between chromatin loci, showing that compartmentalization is stabilized when fragments are larger than 10-25 kb and smaller chromatin fragments can lead to gradual loss of genome organization. Lamin-associated domains are more stable compared to speckle- and polycomb-associated loci, and cohesin-mediated loops dissolve after fragmentation. This technique provides a genome-wide view of chromosome interaction dynamics.
Article
Multidisciplinary Sciences
Jianjie Li, Xiaodong Shu, Jun Xu, Sek Man Su, Un In Chan, Lihua Mo, Jianlin Liu, Xin Zhang, Ragini Adhav, Qiang Chen, Yuqing Wang, Tingting An, Xu Zhang, Xueying Lyu, Xiaoling Li, Josh Haipeng Lei, Kai Miao, Heng Sun, Fuqiang Xing, Aiping Zhang, Chuxia Deng, Xiaoling Xu
Summary: This study explores the mechanism behind the poor response to immune checkpoint blockade in breast cancers caused by BRCA1 deficiency. The authors identify the activation of S100A9-CXCL12 signaling and the accumulation of myeloid-derived suppressor cells as contributing factors. They also demonstrate that the combination of inhibitors targeting S100A9-CXCL12 signaling and alpha PD-1 antibody can effectively suppress the oncogenic actions and improve immunotherapy response.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Huixin Zhu, Zitong Li, Juan Bai, Ping Jiang, Xianwei Wang, Xing Liu
Summary: This study characterized the subcellular localization of PEDV proteins using multi-labeled fluorescent immunocytochemistry. The results revealed the distribution of different proteins in the cytoplasm, nucleus, endoplasmic reticulum, Golgi apparatus, and mitochondria, providing insights into their functions.
Article
Microbiology
Tsung-Yu Chao, Yi-Ying Cheng, Zi-Yun Wang, Tien-Fang Fang, Yu-Ruei Chang, Chi-Shane Fuh, Mei-Tzu Su, Yuan-Wei Su, Pang-Hung Hsu, Yu-Chen Su, Yu-Ching Chang, Ting-Yau Lee, Wei-Han Chou, Jaap M. Middeldorp, Jaakko Saraste, Mei-Ru Chen
Summary: Upon EBV lytic reactivation, the virus-encoded DNA replication machinery functions in the nucleus, while the newly synthesized DNA is encapsidated and transported to the cytoplasm for final virus assembly. The single-stranded DNA binding protein BALF2 executing functions within the nucleus was also identified in the tegument layer of mature virions. We are interested in how BALF2 is packaged into the tegument of virions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Lien B. Lai, Stella M. Lai, Eric S. Szymanski, Mridu Kapur, Edric K. Choi, Hashim M. Al-Hashimi, Susan L. Ackerman, Venkat Gopalan
Summary: n-Tr20 is a neuron-specific, cytoplasmic tRNA isodecoder that affects seizure susceptibility, neuronal excitability, and translation signaling in mice. The C50U substitution in n-Tr20 contributes to neurodegeneration and interacts with Gtpbp1 or Gtpbp2 mutations. Defective tRNA biogenesis may be the basis for neuronal dysfunction in mice with the C50U substitution.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Helene Tran, Michael P. Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L. Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M. King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K. Watts, Robert H. Brown
Summary: The study successfully generated and optimized ASOs that blunt the G(4)C(2) repeat-containing transcripts in the C9ORF72 gene, demonstrating potential therapeutic efficacy for patients with ALS and FTD.
Review
Biochemistry & Molecular Biology
Izchel Figarola-Centurion, Martha Escoto-Delgadillo, Gracia Viviana Gonzalez-Enriquez, Juan Ernesto Gutierrez-Sevilla, Eduardo Vazquez-Valls, Blanca Miriam Torres-Mendoza
Summary: HIV-associated neurocognitive disorder (HAND) is a significant concern, affecting 40% of the population. Recent research has shown that the viral protein Tat is responsible for neuronal alteration, leading to endoplasmic reticulum stress and mitochondrial dysfunction. Activation of SIRTs has been found to promote neuroprotection in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ines T. Afonso, Patricia Lima, Andre Conceicao, Carlos A. Matos, Clevio Nobrega
Summary: Age plays an important role in the onset and progression of SCA2 disease. Aged animals injected with expanded ataxin-2 showed aggravated SCA2 disease phenotype, indicating the significance of aging in SCA2 pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ribhav Mishra, Anurag Bansal, Amit Mishra
Summary: Ribosomes synthesize proteins according to cellular demands, but defects in the process can lead to non-functional proteins. Cells rely on quality control mechanisms like LISTERIN to eliminate abnormal proteins. LISTERIN's role in regulating protein quality is crucial for brain health and development, with implications for neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Shenkman, Michal Geva, Noga Gershoni-Emek, Michael R. Hayden, Gerardo Z. Lederkremer
Summary: Pridopidine can significantly alleviate mHtt-induced ER stress, reduce markers of the three UPR branches with the strongest effect on the PERK branch. This effect is S1R-dependent and may be achieved by increasing insoluble S1R and stabilizing activated S1R oligomers.
JOURNAL OF NEUROCHEMISTRY
(2021)