Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1

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(2015) Olga Sin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

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Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy

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It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles

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Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

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Protein Kinases Are Associated with Multiple, Distinct Cytoplasmic Granules in Quiescent Yeast Cells

(2014) Khyati H. Shah et al.   GENETICS

Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes

(2014) Chongxu Zhang et al.   PROTEIN SCIENCE

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Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma

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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

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Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

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Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

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Aggregate Clearance of α-Synuclein inSaccharomyces cerevisiaeDepends More on Autophagosome and Vacuole Function Than on the Proteasome

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Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

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P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

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Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II

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The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1

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Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs

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A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

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Cbk1 Regulation of the RNA-Binding Protein Ssd1 Integrates Cell Fate with Translational Control

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Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

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Identification and characterization of FUS/TLS as a new target of ATM

(2008) Mary Gardiner et al.   BIOCHEMICAL JOURNAL

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

(2008) Yan Wang et al.   FASEB JOURNAL

A role for Q/N-rich aggregation-prone regions in P-body localization

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Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

An in Vivo Map of the Yeast Protein Interactome

(2008) K. Tarassov et al.   SCIENCE

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System

(2008) Daniel J Hogan et al.   PLOS BIOLOGY

The NDR/LATS Family Kinase Cbk1 Directly Controls Transcriptional Asymmetry

(2008) Emily Mazanka et al.   PLOS BIOLOGY