Article
Biochemistry & Molecular Biology
Debdatta Halder, Ditipriya Mallick, Ananya Chatterjee, Siddhartha S. Jana
Summary: Cell migration is a crucial process in cancer metastasis, immune-cell navigation, stem cell homing, and development, influenced by the diverse migratory mechanisms utilized by cells due to the heterogeneity of tissue environments. The activity and complexity of actomyosin networks play a significant role in cell motility mechanisms. Understanding the regulation and function of nonmuscle myosin IIs is important for designing therapeutic strategies to inhibit cancer metastasis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandra A. Hemkemeyer, Veith Vollmer, Vera Schwarz, Birgit Lohmann, Ulrike Honnert, Muna Taha, Hans-Joachim Schnittler, Martin Baehler
Summary: The migration of cells depends on the coordination between Rac-induced actin polymerization and the recruitment of Myo9b, which locally inhibits Rho activity to enhance directional cell migration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G. Allen, Wasay M. S. Qureshi, Kathryn E. Hentges, Angelino Calderone
Summary: The study found that the appearance of nestin in neonatal rat ventricular cardiomyocytes was associated with a migratory phenotype, and the cotreatment with p38 mitogen-activated protein kinase inhibitor promoted the synthesis of nestin. Additionally, the reorganization of nonmuscle myosin IIB and its physical interaction with nestin may act together to facilitate the migratory phenotype in cardiomyocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaobing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huang
Summary: This study reveals a novel molecular mechanism by which BDNF regulates the activity of MLC2, providing new insights into the functional regulation of NM II in the nervous system.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Xinyu Liu, Pin Huan, Baozhong Liu
Summary: This study reveals the crucial role of nonmuscle myosin II (NM II) in the morphogenesis of the larval shell field in L. goshimai. Inhibition of NM II phosphorylation results in the complete loss of the larval shell plate and altered morphology and cell specification in the shell field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Multidisciplinary Sciences
Andrei I. Ivanov, Susana Lechuga, Armando Marino-Melendez, Nayden G. Naydenov
Summary: The integrity and functions of epithelial barriers depend on the formation of adherens junctions and tight junctions, which are associated with the cortical cytoskeleton composed of actin filaments and nonmuscle myosin II motors. Different actin and myosin isoforms play distinct roles in the assembly, stability, and remodeling of junctions. This review focuses on the roles of actin and myosin in controlling the integrity and barrier properties of various epithelia.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Virology
Jian Chen, Jian Liu, Zhilu Chen, Daobin Feng, Cuisong Zhu, Jun Fan, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: This study reveals the crucial role of nonmuscle myosin IIA (MYH9) in regulating influenza A virus (IAV) infection and replication. MYH9 can interact with the viral nucleoprotein (NP) and interrupt the formation of viral ribonucleoprotein (vRNP) complexes, leading to a suppression of viral RNA transcription and replication. These findings shed new light on the complicated interactions between IAV and its host, making MYH9 a potential target for antiviral drug development.
Article
Biology
Ryan Y. Nguyen, Hugh Xiao, Xiangyu Gong, Alfredo Arroyo, Aidan T. Cabral, Tom T. Fischer, Kaitlin M. Flores, Xuchen Zhang, Marie E. Robert, Barbara E. Ehrlich, Michael Mak
Summary: Liver cancer treatment is complicated due to different responses to drugs among its subtypes. This study demonstrates the effectiveness of targeting biophysical phenotypes related to cytoskeleton properties that are usually masked in traditional drug screens. The study investigated how heterogeneity in liver cancer subtypes contributes to differences in invasive phenotypes and drug response.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biophysics
Takumi Saito, Wenjing Huang, Tsubasa S. Matsui, Masahiro Kuragano, Masayuki Takahashi, Shinji Deguchi
Summary: This study investigates the characteristics of nonmuscle myosin II (NMII) in actin stress fibers in nonmuscle cells and proposes factors that determine the number of NMII. Experimental results confirm that the number of NMII lies between the functions of bearing cellular tension under static conditions and promptly disintegrating upon forced cell shortening, allowing cells to adaptively respond to mechanical stress.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Cell Biology
Alejandra Valdivia, Charity Duran, Mingyoung Lee, Holly C. Williams, Moo-Yeol Lee, Alejandra San Martin
Summary: Cell migration is crucial for biological and pathological processes. Establishing cell polarity and forming a single lamellipodium at the leading edge is important for efficient directional cell migration. Nox1 deficiency affects cell polarity and lamellipodium formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fang Zhang, Yong Li, Lipeng Gan, Xiaomei Tong, Dandan Qi, Qihui Wang, Xin Ye
Summary: The study identified lncRNA MAFG-AS1 as upregulated in HBV-related HCC tissues, leading to enhanced proliferation and migration of HCC cells, suggesting its potential oncogenic role in HBV-related HCC development.
Article
Chemistry, Multidisciplinary
Zhiang Zhang, Jikun Jiang, Xiao (Xiao) Liu, Xin Wang, Luyao Wang, Yuankun Qiu, Zhanfei Zhang, Yiting Zheng, Xueyun Wu, Jianghu Liang, Congcong Tian, Chun-Chao Chen
Summary: This study demonstrated that anchoring acetylcholine (ACh(+)) on the surface of a quadruple-cation perovskite can improve band alignment, minimize V-oc loss, and passivate defects, resulting in efficient and stable perovskite solar cells. The ACh(+) treatment significantly enhanced power conversion efficiency (PCE) and open-circuit voltage (V-oc) while reducing hysteresis index, making it a promising strategy for PSCs preparation.
Article
Multidisciplinary Sciences
Kumarjeet Banerjee, Shekhar Saha, Shaoli Das, Suman Ghosal, Indranil Ghosh, Abhimanyu Basu, Siddhartha S. Jana
Summary: This study reveals that microRNAs can regulate the expression of nonmuscle myosin II(C) through both canonical and non-canonical binding sites, thereby affecting the development of tumor cells. Specifically, modulating the expression of mmu-miR-532-3p in mouse mammary tumor cells enhances their tumorigenic potential.
Article
Cell Biology
Jianmin Liu, Daoquan Liu, Junchao Zhang, Weixiang He, Yuhang Guo, Yan Li, Ping Chen, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate volume (PV) varies greatly among benign prostatic hyperplasia (BPH) patients, and estimating PV is crucial for determining the most suitable treatment approach. However, the mechanisms underlying these PV differences are still unknown. Our study examined the expression and functional activities of myosin II isoforms in hyperplastic prostates of varying volumes. The findings suggest that alterations in the myosin II system may play a role in the pathophysiological mechanisms responsible for PV differences in BPH patients.
CELLULAR SIGNALLING
(2023)
Article
Genetics & Heredity
Pei-Yu Wang, Wei-Cheng Lin, Yi-Cheng Tsai, Mei-Ling Cheng, Yu-Hung Lin, Shu-Heng Tseng, Archan Chakraborty, Li-Mei Pai
Article
Biochemistry & Molecular Biology
Li-Mei Pai, Pei-Yu Wang, Wei-Cheng Lin, Archan Chakraborty, Chau-Ting Yeh, Yu-Hung Lin
Article
Cell Biology
Gerson Dierley Keppeke, Chia Chun Chang, Min Peng, Li-Yu Chen, Wei-Cheng Lin, Li-Mei Pai, Luis Eduardo Coelho Andrade, Li-Ying Sung, Ji-Long Liu
Article
Cell Biology
Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai
Article
Biochemistry & Molecular Biology
Hsien-Li Huang, Chih-Hung Chen, Chia-Te Kung, Yi-Chen Li, Pei-Hsun Sung, Huey-Ling You, Yu-Hung Lin, Wan-Ting Huang
BIOMEDICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Shin-Chih Lin, Chia-Hung Lin, Nien-Chu Shih, Hsin-Ling Liu, Wen-Chao Wang, Kun-Yang Lin, Zih-Yu Liu, Yu-Jhen Tseng, Hsueh-Kai Chang, Yi-Cheng Lin, Yi-Chen Yeh, Hiroshi Minato, Takeshi Fujii, Yu-Chung Wu, Mei-Yu Chen, Teh-Ying Chou
Article
Biochemistry & Molecular Biology
Bo-Yuan Hsiao, Chia-Hsin Chen, Ho-Yi Chi, Pei-Ru Yen, Ying-Zhen Yu, Chia-Hsin Lin, Te-Ling Pang, Wei-Chi Lin, Min-Lun Li, Yi-Chen Yeh, Teh-Ying Chou, Mei-Yu Chen
Summary: ABRACL plays a role in cancer cell migration and tumorigenesis by modulating actin dynamics through interaction with Cofilin. High ABRACL expression is associated with distant metastasis in colorectal cancer and depletion of ABRACL expression reduces cell proliferation and tumorigenic growth. The results suggest that ABRACL participates in cancer pathogenesis by regulating actin dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chia-Hung Lin, Chen-Chung Liao, Mei-Yu Chen, Teh-Ying Chou
Summary: This study investigates the O-GlcNAc-feedback regulation of OGT and OGA expression in lung cancer cells, revealing that OGA expression is regulated at the mRNA level while OGT expression is controlled through translation. The research also highlights the important role of 4E-BP1 in maintaining intracellular O-GlcNAc levels homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yen-Yu Lin, Yu-Chao Wang, Da-Wei Yeh, Chen-Yu Hung, Yi-Chen Yeh, Hsiang-Ling Ho, Hsiang-Chen Mon, Mei-Yu Chen, Yu-Chung Wu, Teh-Ying Chou
Summary: Lung adenocarcinoma has a tendency to metastasize to the brain, leading to significant morbidity and mortality. By analyzing primary tumors, it is possible to identify patients at the highest risk for brain metastasis, which can aid medical decision-making. Further research is needed to understand the mechanisms behind these associations and identify potential treatment targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chia-Hung Lin, Chen-Chung Liao, Shu-Ying Wang, Chia-Yi Peng, Yi-Chen Yeh, Mei-Yu Chen, Teh-Ying Chou
Summary: Lung cancer is the most deadly type of cancer, and invasion and metastasis are major challenges in its treatment. O-GlcNAcylation, a protein modification process, is linked to cancer pathogenesis, including invasion and metastasis. However, little is known about O-GlcNAcylated proteins involved in cancer aggressiveness. In this study, we compared the profiles of O-GlcNAcylated proteins in two lung cancer cell lines with different invasive potentials and identified potential candidates involved in cancer aggressiveness. Further characterization of one candidate, SAM68, confirmed its O-GlcNAcylation and suggested its role in regulating lung cancer cell migration and invasion. Our findings provide new insights into the mechanisms of lung cancer progression through O-GlcNAcylated proteins.
Article
Nanoscience & Nanotechnology
Chia-Liang Tsai, Ching-Yun Huang, Yi-Ching Lu, Li-Mei Pai, Daniel Horak, Yunn-Hwa Ma
Summary: In this study, it was found that cyclic strain reduces the internalization of magnetic nanoparticles (MNPs) by vascular smooth muscle cells (VSMCs), possibly due to decreased microvilli number and reduced vesicle size. Additionally, cyclic strain also decreases the uptake of other types of nanoparticles by cells. This finding can enhance the targeted delivery efficiency of nanomedicine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)