期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 459, 期 C, 页码 90-97出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.03.002
关键词
Intestinal epithelium; Thyroid hormone; Thyroid hormone receptor TR; Stem cells; Wnt and notch pathways
资金
- Departement du Rhone de la Ligue contre le cancer [137838]
- Institut National pour le Cancer [PLBIO14-292]
- Fondation ARC [PDF20141202107]
- Fondation ARC pour la Recherche sur le Cancer [PGA1201402000834]
The gastrointestinal tract is a well-characterized target of thyroid hormones and thyroid hormone nuclear receptors TRs, as extensively described in the literature. The paradigm is its important remodelling in amphibians during thyroid hormone-dependent metamorphosis. Interestingly, several studies have described the conservation of this hormonal signal during intestinal development in mammals. Additional data suggested that it may also play a role in intestinal homeostasis, stem cell physiology and progenitor commitment as well as in tumour development. It is worth underlining that in the mammalian intestine the functionality of the TR alpha l receptor is coordinated and integrated with other signalling pathways, such as Wnt and Notch, specifically at the level of stem/progenitor cell populations. Here, we summarize these data and concepts and discuss this new role for thyroid hormones and the TRa1 receptor in the biology of intestinal epithelial precursor cells. (C) 2017 Elsevier B.V. All rights reserved.
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