Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation

Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light

(2017) Wan-Ju Chen et al.   EXPERIMENTAL EYE RESEARCH

RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Müller glia cells

(2017) Yuki Inoue et al.   JOURNAL OF NEUROCHEMISTRY

VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases

(2017) Yun-Zheng Le   VISION RESEARCH

Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

(2017) Elena Rampanelli et al.   Scientific Reports

Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications

(2016) Elizabeth P. Moran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis

(2016) Rui Cheng et al.   DIABETES

Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy

(2016) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy

(2016) Yanli Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy

(2016) Francesco Saverio Sorrentino et al.   LIFE SCIENCES

Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway

(2016) YAN SUN et al.   Experimental and Therapeutic Medicine

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation

(2015) Jeong Su Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

(2015) K. Eastlake et al.   GLIA

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

(2015) Yanhong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Proliferator–Activated Receptor α Protects Capillary Pericytes in the Retina

(2014) Lexi Ding et al.   AMERICAN JOURNAL OF PATHOLOGY

An Update on the Molecular Actions of Fenofibrate and Its Clinical Effects on Diabetic Retinopathy and Other Microvascular End Points in Patients With Diabetes

(2014) J. E. Noonan et al.   DIABETES

NRF2 plays a protective role in diabetic retinopathy in mice

(2013) Zhenhua Xu et al.   DIABETOLOGIA

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

(2013) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes

(2012) Y. Zhong et al.   DIABETES

Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models

(2012) Ying Chen et al.   DIABETES

Clofibrate PPARα Activation Reduces Oxidative Stress and Improves Ultrastructure and Ventricular Hemodynamics in No-flow Myocardial Ischemia

(2012) Luz Ibarra-Lara et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

(2010) J. Li et al.   DIABETES

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY