Article
Environmental Sciences
Ruhi Kabakci, Kendra L. Clark, Michele R. Plewes, Corrine F. Monaco, John S. Davis
Summary: The study investigated the effects of PFOA on bovine granulosa cell function. Results showed that PFOA inhibited steroid hormone secretion and altered the expression of key enzymes required for steroidogenesis. PFOA also caused mitochondrial dysfunction and increased autophagy. These findings suggest that PFOA may negatively impact livestock reproductive health.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Dongxu Zhang, Jiasheng Hu, Heming Li
Summary: This study found that PFOA can inhibit androgen biosynthesis in immature Leydig cells (ILCs) by selectively targeting key enzymes in the synthesis pathway. These findings provide new insights into the toxicity of PFOA on the reproductive system.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Cell Biology
Jingfang Zhai, William H. H. Kongsberg, Yinbo Pan, Canhua Hao, Xiaojing Wang, Jie Sun
Summary: Research suggests that dietary changes can alter epigenetic marks associated with aging. Caloric restriction (CR) is considered an intervention to regulate aging and prolong lifespan, and has made some progress by regulating aging-related signaling pathways and intercellular signaling molecules. This review focuses on autophagy and epigenetic modifications to elaborate the molecular mechanisms by which CR delays aging by triggering autophagy, epigenetic modifications, and their interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lea P. Wilhelm, Juan Zapata-Munoz, Beatriz Villarejo-Zori, Stephanie Pellegrin, Catarina Martins Freire, Ashley M. Toye, Patricia Boya, Ian G. Ganley
Summary: This study reveals that both mitophagy and pexophagy are activated upon iron chelation in a BNIP3L/NIX-dependent manner. The NIX protein, known as a mitophagy receptor, is also found to localize to peroxisomes and drive pexophagy independently.
Article
Cell Biology
Lea Schuermanns, Andrea Hamann, Heinz D. Osiewacz
Summary: The maintenance of cellular homeostasis is crucial for preventing the degeneration of biological systems. In this study, the researchers found that an oleic acid diet can extend the lifespan of cells by restoring membrane trafficking and altering mitochondrial respiratory chain.
Review
Microbiology
Heinz D. Osiewacz, Lea Schuermanns
Summary: Research on Podospora anserina has identified a network of molecular pathways affecting biological aging, including control of mitochondria and mtDNA stability. Imbalance of reactive oxygen species levels can lead to molecular damage, with damaged compounds being degraded by enzymes or autophagy.
Article
Food Science & Technology
Yuan Yang, Guoqing Fu, Xueyi Zhao, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Ding Yuan, Jie Wu, Ting Wang, Changcheng Zhang, Haixia Zhao
Summary: PFOA disrupts tight junction function in Sertoli cells by blocking autophagic flux, leading to male reproductive toxicity. This finding provides clues for effective prevention and treatment of PFOA-induced male reproductive toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kequan Fu, Wenbing Chen, Mingzhu Meng, Huimin Zhao, Haoxing Yuan, Yinan Wang, Ying Ren, Yi Yun, Dong Guo
Summary: The adenosine A1 receptor is an important target for metabolic disorders and plays a significant role in regulating free fatty acid levels. This study examined the effect of an allosteric modulator on the action of an A1 receptor agonist in regulating lipolysis. The results showed that the allosteric modulator enhanced the antilipolytic action of the agonist by slowing down its dissociation from the receptor and downregulating the cAMP/HSL pathway. This study highlights the potential application of A1 receptor allosteric modulators in the treatment of metabolic diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Gang Wang, Ruili Pan, Xi Liang, Xiaobing Wu, Yanmin Wu, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: The study found that both subacute and subchronic exposure to PFOA can induce liver inflammation, disrupt antioxidative homeostasis, and cause liver histological abnormalities, possibly related to gut microbiota dysbiosis. Additionally, exposure to PFOA affects the functional capabilities of microbial communities and reduces levels of short-chain fatty acids, which may contribute to liver damage.
Article
Multidisciplinary Sciences
Zhuang Hao, Zhen Li, Jinjin Huo, Jiandong Li, Fenghua Liu, Peng Yin
Summary: The study demonstrated that Chinese wolfberry and Astragalus extract had a significant effect on the antioxidant capacity of Tibetan pig liver, enhancing antioxidant ability through regulation of oxidative stress-related genes and signaling pathways. The findings suggest a potential mechanism for improving liver health in pigs.
Article
Biochemistry & Molecular Biology
Xiaofan Wei, Yunash Maharjan, Debra Dorotea, Raghbendra-Kumar Dutta, Donghyun Kim, Hyunsoo Kim, Yizhu Mu, Channy Park, Raekil Park
Summary: PEX16 regulates peroxisome abundance and function through pexophagic degradation, which is indispensable for maintaining peroxisome homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wang
Summary: The study revealed that PFOA can increase liver weight, reduce uterine index, and induce toxic effects on liver and uterine tissues. Additionally, various factors expressed in uterine cells showed dose-dependent changes in response to PFOA exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Coralie F. Daussy, Mathilde Galais, Baptiste Pradel, Veronique Robert-Hebmann, Sophie Sagnier, Sophie Pattingre, Martine Biard-Piechaczyk, Lucile Espert
Summary: The immunodeficiency observed in HIV-1-infected patients is mainly due to bystander CD4(+)T lymphocyte cell death, triggered by the viral envelope glycoprotein Env-induced autophagy and oxidative stress. Env-mediated autophagy targets peroxisomes, leading to the degradation of these organelles and contributing to immunodeficiency induced by HIV-1.
Article
Environmental Sciences
Abdel Halim Harrath, Abdulkarem Alrezaki, Maroua Jalouli, Nouf Al-Dawood, Waleed Dahmash, Lamjed Mansour, Alexander Sirotkin, Saleh Alwasel
Summary: This study found that exposure to benzene gas adversely affects ovarian function and structure in female rats, causing histopathological changes and altering reproductive steroid hormone release. Additionally, benzene exposure induces apoptosis and autophagy in the ovaries, and affects the regulation of several genes involved in ovarian folliculogenesis and steroidogenesis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Jialu Bao, Yan Zhang, Linchao Zhang, Xiaodan Wang
Summary: Exposure of pregnant mice to PFOA was found to have a damaging effect on testicular development in male offspring mice, leading to reduced testosterone content and increased apoptosis. Genes associated with snRNA and THOC were dysregulated after PFOA exposure, indicating potential mechanisms underlying the observed effects.