Article
Biochemistry & Molecular Biology
Elwira Sieniawska, Lukasz Swiatek, Kouadio Ibrahime Sinan, Gokhan Zengin, Anastazja Boguszewska, Malgorzata Polz-Dacewicz, Nabeelah Bibi Sadeer, Ouattara Katinan Etienne, Mohamad Fawzi Mahomoodally
Summary: This study evaluated the biological and chemical properties of Ficus sur Forssk. extracts, revealing their antioxidant, enzyme inhibitory, anticancer, and antiviral activities. The findings provide valuable scientific data for the development of innovative phytopharmaceuticals.
Review
Biochemistry & Molecular Biology
Wei Li, Gui-Hua Tang, Sheng Yin
Summary: This review provides an extensive coverage of selaginellins discovered from 2007 to 2020, including 61 natural ones and 52 synthetic analogues. It summarizes the isolation, chemical structures, plausible biosynthetic pathways, bioactivity, and total synthesis of these selaginellins for the first time, highlighting the potential treasure trove of chemically diverse selaginellins waiting to be discovered in the vast uninvestigated Selaginella species.
NATURAL PRODUCT REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Yu Luo, Yuqing Jian, Yingkai Liu, Sai Jiang, Daniyal Muhammad, Wei Wang
Summary: Flavanols, a common class of secondary plant metabolites, have beneficial health properties and are considered functional ingredients in dairy products. Research on flavanols and their derivatives lays the groundwork for further studies.
Review
Plant Sciences
Marwa H. A. Hassan, Ahlam Elwekeel, Abeer Moawad, Naglaa Afifi, Elham Amin, Dalia El Amir
Summary: Family Crassulaceae is a large family of dicotyledonous angiosperms with a unique form of photosynthesis. Besides being used as ornamental plants, the chemical content and biological activities of many members of this family have been extensively studied. However, there are still many species that have not been adequately researched, providing potential for further exploration.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Multidisciplinary Sciences
Jolly Oder Akullo, Beatrice N. Kiage-Mokua, Dorothy Nakimbugwe, Jeremiah Ng'ang'a, John Kinyuru
Summary: This study investigated the phytochemical profile and antioxidant activity of ginger and garlic consumed in Uganda. The results showed that ginger extracts had higher total phenolic and flavonoid content compared to garlic. The antioxidant activity of the extracts correlated positively with the total phenolic and flavonoid content, and the ethanol extracts of local ginger exhibited the best antioxidant activity. These findings suggest that ginger and garlic have strong antioxidant activity and could be used as natural antioxidants in food and medicine applications.
Review
Plant Sciences
Sergio Liga, Cristina Paul, Francisc Peter
Summary: Recently, there has been growing interest in natural sources as raw materials for the development of new value-added products. Flavonoids, a type of polyphenol, have diverse biological properties and are classified into several classes based on their structure. Current research on flavonoids focuses on identification, extraction, characterization, and applications to health benefits. This review provides an updated overview of natural flavonoids, their biological activity, extraction techniques, and future perspectives.
Review
Pharmacology & Pharmacy
Rajeev K. Singla, Vivek Dhir, Reecha Madaan, Deepak Kumar, Simranjit Singh Bola, Monika Bansal, Suresh Kumar, Ankit Kumar Dubey, Shailja Singla, Bairong Shen
Summary: Through a critical assessment of unperformed pharmacological activities, this review aims to identify research gaps and validate the traditional claims of various Alternanthera species. The review will assist natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Naoual El Menyiy, Fatima-Ezzahrae Guaouguaou, Aicha El Baaboua, Nasreddine El Omari, Douae Taha, Najoua Salhi, Mohammad Ali Shariati, Tarik Aanniz, Taoufiq Benali, Gokhan Zengin, Mohamed El-Shazly, Imane Chamkhi, Abdelhakim Bouyahya
Summary: Centaurium erythraea is an important medicinal plant used in traditional medicine to treat various diseases. It exhibits diverse biological properties and contains several classes of secondary metabolites, confirming the link between traditional medicinal use and scientific experiments. Further investigation using in vivo pharmacological assays, toxicological tests, and pharmacokinetic studies are recommended to validate its traditional use.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Omyma Rabie, Heba A. S. El-Nashar, Mina Y. George, Taghreed A. Majrashi, Tarfah Al-Warhi, Fatma E. Hassan, Wagdy M. Eldehna, Nada M. Mostafa
Summary: The study found that Callistemon subulatus extract (CSE) has neuroprotective effects and can effectively alleviate the symptoms of chemobrain caused by cyclophosphamide (CPA), improving spatial and short-term memory. Additionally, CSE counteracts oxidative stress and the inflammatory response induced by CPA through its antioxidant properties.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Mostafa H. H. Baky, Mohamed R. R. Elgindi, Enas M. M. Shawky, Haitham A. A. Ibrahim
Summary: This study investigated the phytochemical composition of Ludwigia adscendens subsp. diffusa and screened its biological activities. The aerial parts of L. adscendens were found to contain various phytochemicals with potential health benefits.
Article
Plant Sciences
Tao Tao, Ping Zhang, Zhi Zeng, Min Wang
Summary: Natural products have a critical role in drug development, especially in cancer therapy. There is increasing evidence that many natural products may modulate autophagy in cervical cancer. Understanding the mechanisms of these natural products helps to develop medications for cervical cancer treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chun-Yu Li, Hao-Nan Wang, Rong-Jing He, Jian Huang, Li-Lin Song, Yun-Qing Song, Peng-Chao Huo, Jie Hou, Guang Ji, Guang-Bo Ge
Summary: This study discovered a natural compound called AMF that can inhibit lsBSH produced by gut microbes, thus modulating bile acid metabolism. AMF reversibly inhibits the catalytic activity of lsBSH in a mixed-inhibition manner and binds to lsBSH through hydrophobic interactions and hydrogen bonding.
Review
Pharmacology & Pharmacy
Ingrid Andrea Rodriguez, Mairim Serafini, Izabel Almeida Alves, Karen Luise Lang, Fatima Regina Mena Barreto Silva, Diana Marcela Aragon
Summary: Diabetes mellitus (DM) is a growing health problem globally, characterized by high blood glucose levels. This review explores the potential of natural products as alternative therapeutic strategies for DM treatment. By analyzing 19 patents from the Espacenet database, it was found that plants, seaweeds, fungi, and minerals were used as raw materials, and metabolites such as tannins, organic acids, polyphenols, terpenes, and flavonoids showed potential activity. Additionally, pharmaceutical technology strategies, such as cellular transportation and solid forms with special drug delivery profiles, can enhance the safety and efficacy of these natural products.
Article
Plant Sciences
Rodrigo Duarte-Casar, Juan Carlos Romero-Benavides
Summary: Tragia, a genus of plants in the Euphorbiaceae family, has medicinal uses such as antibacterial, anti-inflammatory, anticancer, and reproductive health. Research has confirmed ethnopharmacological claims for some Old World species, but there is still limited research on New World species. Phytochemicals like ethers, hydrocarbons, flavonoids, and sterols have been isolated from Tragia plants.
Article
Cardiac & Cardiovascular Systems
Laura Seese, Victor O. Morell, Melita Viegas, Mary Keebler, Gavin Hickey, Yisi Wang, Arman Kilic
Summary: This study developed and validated a 13-point risk score for predicting 1-year mortality in adult congenital heart disease patients undergoing orthotopic heart transplantation. The risk score showed a strong correlation with observed mortality rates and could help in improving recipient selection for heart transplantation in this population.
ANNALS OF THORACIC SURGERY
(2021)
Review
Pharmacology & Pharmacy
Natalia F. F. Pirolla, Victor S. Batista, Flavia Pereira Dias Viegas, Vanessa Silva Gontijo, Caitlin R. McCarthy, Claudio Viegas Jr, Nailton M. Nascimento-Junior
Summary: This article summarizes the therapeutic targets, drugs, and synthetic routes involved in Alzheimer's disease, as well as some bioactive compounds under development to illustrate recent research advances in medicinal chemistry. The importance of multi-target approaches, including examples from research projects, is emphasized to guide the search for more effective drug candidates. This review covers the period between 2001 and early 2020.
CURRENT DRUG TARGETS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Garrett N. Coyan, Luciana Da Fonseca Da Silva, Jose P. Da Silva, Melita Viegas, Victor O. Morell, Mario Castro-Medina
Summary: This study presents a technique for constructing a handmade tricuspid valved polytetrafluoroethylene conduit for patients of all ages requiring right ventricular outflow tract reconstruction. The conduit provides an economically advantageous and readily available option globally, without sacrificing surgical results.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Laura Seese, Harma K. Turbendian, Dylan Thibault, Luciana Da Fonseca Da Silva, Kevin Hill, Mario Castro-Medina, Melita Viegas, Jose P. Da Silva, Jeffery P. Jacobs, Marshall L. Jacobs, Michael Shillingford, Victor O. Morell
Summary: Rastelli and Nikaidoh procedures are the predominant repair strategies for patients with DORV-TGA and TGA-VSD-LVOTO, mainly performed at high-volume institutions with similar early outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Garrett N. Coyan, Carlos Diaz-Castrillon, Mario Castro-Medina, Luciana Da Fonseca Da Silva, Melita Viegas, Victor O. Morell
Summary: High-risk status in patients undergoing stage 1 palliation is associated with increased mortality, length of stay, and readmission rates after stage 2 palliation. However, high-risk patients have similar survival to low-risk patients after stage 3 palliation.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Samar R. El Khoudary, Anthony Fabio, Jessie W. Yester, Matthew L. Steinhauser, Adam B. Christopher, Frank Gyngard, Phillip S. Adams, Victor O. Morell, Melita Viegas, Jose P. Da Silva, Luciana F. Da Silva, Mario Castro-Medina, Andrew McCormick, Miguel Reyes-Mugica, Michelle Barlas, Honghai Liu, Dawn Thomas, Niyatie Ammanamanchi, Rachel Sada, Megan Cuda, Elizabeth Hartigan, David K. Groscost, Bernhard Kuhn
Summary: This study aims to evaluate the use of propranolol in infants with ToF/PS to increase cardiomyocyte division and potentially reduce adverse RV remodeling. The trial design includes a randomized, double-blind, placebo-controlled methodology with the primary endpoint being cardiomyocyte division.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ueveton da Silva, Bruno Ferreira, Bianca de Sousa, Gabriela Furlani, Robert Barreto, Ana Paula Agrizzi, Joao Paulo Leite, Marcelo dos Santos, Eduardo Varejao
Summary: The leaf extract of the Brazilian medicinal plant Garcinia gardneriana shows promising antifungal activity against the coffee leaf rust fungus, without phytotoxic effects on sensitive plant species. However, its inhibitory activity against acetylcholinesterase is relatively low.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Critical Care Medicine
Catherine Gretchen, Hulya Bayir, Patrick M. Kochanek, Kristine Ruppert, Melita Viegas, David Palmer, Nahmah Kim-Campbell
Summary: This study investigates potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and identifies younger age and higher mean Pao(2) x cardiopulmonary bypass duration as risk factors. Severe hemolysis is associated with longer hospital and ICU lengths of stay as well as acute kidney injury.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Entomology
Paula Tatiana Lopes Seixas, Antonio Jacinto Demuner, Luiz Claudio Almeida Barbosa, Cristiane Isaac Cerceau, Daiane Einhardt Blank, Marcelo Henrique Dos Santos, Elizeu de Sa Farias, Marcelo Coutinho Picanco
Summary: The larvicidal effect of essential oils from the leaves of three Artemisia species against A. aegypti was evaluated. The EO of Artemisia camphorata was found to be the most effective, with germacrene D-4-ol as the main active constituent. It can be promising for developing natural larvicides against A. aegypti.
JOURNAL OF APPLIED ENTOMOLOGY
(2023)
Article
Chemistry, Medicinal
Carolina Girotto Pressete, Flavia Pereira Dias Viegas, Thamara Gaspar Campos, Ester Siqueira Caixeta, Joao Adolfo Costa Hanemann, Guilherme Alvaro Ferreira-Silva, Bruno Zavan, Alexandre Ferro Aissa, Marta Miyazawa, Claudio Viegas-Jr, Marisa Ionta
Summary: Melanoma, the most aggressive form of skin cancer, remains highly metastatic and deadly despite advances in immunotherapy and targeted therapies. In this study, we designed hybrid compounds combining pharmacophores from piperine and chlorogenic acid to explore potential antitumoral properties. Among the compounds tested, PQM-277 (3a) showed the highest cytotoxicity on melanoma cells, inhibiting mitosis progression and altering gene expression related to G2/M transition and mitosis onset. Furthermore, compound 3a interacted with the CUL1-RBX1 complex and induced apoptosis by increasing the BAX/BCL2 ratio. These findings suggest that compound 3a has promising potential as an antitumor candidate for melanoma treatment, especially in refractory cases.
Meeting Abstract
Cardiac & Cardiovascular Systems
Shwetabh Tarun, Carlos Diaz-Castrillon, Melita Viegas, Mario Castro, Luciana Da Fonseca Da Silva, Victor O. Morell
Meeting Abstract
Cardiac & Cardiovascular Systems
Carlos Diaz-Castrillon, Melita Viegas, Shwetabh Tarun, Jordann Lewis, Tamara Maihle, Mario Castro, Victor O. Morell
Meeting Abstract
Cardiac & Cardiovascular Systems
Ryan Halickman, Alexandra Erdmann, Sara Trucco, Melita Viegas, Victor Morell, Jacqueline Kreutzer, Bryan Goldstein
PEDIATRIC CARDIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maria C. F. Dias, Bianca L. de Sousa, Marisa Ionta, Robson R. Teixeira, Thiago Q. Goulart, Guilherme A. Ferreira-Silva, Eduardo J. Pilau, Marcelo H. dos Santos
Summary: Benzophenones have multiple biological activities, and the synthesized 1,2,3-triazole-benzophenone derivatives exhibit good antioxidant, anticancer, and photoprotective effects, with derivatives 19, 20, and 24 showing cytotoxicity and cell cycle arrest in melanoma cells.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Food Science & Technology
Edmar J. O. Bazani, Matheus S. Barreto, Antonio J. Demuner, Marcelo H. Dos Santos, Cristiane I. Cerceau, Daiane E. Blank, Maria J. M. Firmino, Gustavo S. F. Souza, Mathews O. K. Franco, Willian T. Suarez, Paulo C. Stringheta
Summary: A low-cost and simple method for in situ determination of total phenols and antioxidants in tomato, strawberry, and coffee through digital imaging was developed and validated in this study. The method showed simple manipulation, fast response, and environmental safety, making it a promising tool for future research in this area.
FOOD ANALYTICAL METHODS
(2021)