期刊
MICROFLUIDICS AND NANOFLUIDICS
卷 21, 期 6, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-017-1941-4
关键词
Microfluidic device; Organ-on-a-chip (Organ Chip); Thermoplastic elastomer; SEBS; Injection molding
资金
- Defense Advanced Research Projects Agency (DARPA) [W911NF-12-2-0036]
The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses significant challenges for high volume manufacturing and its tendency to absorb small hydrophobic compounds limits its usefulness as a material in devices used for drug evaluation studies. Here, we demonstrate that a subset of optically clear, elastomeric, styrenic block copolymers based on styrene-ethylene-butylene-styrene exhibit reduced absorption of small hydrophobic molecules and drug compounds compared to PDMS and that they can be fabricated into microfluidic devices with fine features and the flexibility required for Organ Chips using mass production techniques of injection molding and extrusion.
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