Article
Chemistry, Multidisciplinary
Ouyang Dan, Chuanzhe Wang, Chao Zhong, Juan Lin, Gang Xu, Guane Wang, Zian Lin
Summary: In this study, novel LDI-MS substrates were designed to enhance the sensitivity of mass signals and achieve high accuracy diagnosis of different saccharides and central precocious puberty (CPP).
Article
Chemistry, Analytical
Xufang Hu, Zongping Wang, Haolin Chen, An Zhao, Nianrong Sun, Chunhui Deng
Summary: An advanced metabolic analysis tool based on highly porous metal oxides derived from metal-organic frameworks (MOFs) is developed in this study. The tool successfully differentiates and stages renal cell carcinoma (RCC), as well as identifies the size of tumors. This achievement shows promising prospects for designer matrix-based analytical tools in disease diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Jiri Kratochvil, Vadym Prysiazhnyi, Filip Dycka, Ondrej Kylian, Peter Kus, Petr Sezemsky, Jan Sterba, Vitezslav Stranak
Summary: The use of nanoparticles in laser desorption/ionization mass spectrometry can improve signal intensity and stability, as well as provide a high detection limit and imaging capability. This technique offers a valuable alternative to other laser desorption/ionization-based detection methods.
APPLIED SURFACE SCIENCE
(2021)
Review
Biochemical Research Methods
Lanaia Itala Louzeiro Maciel, Ricardo Alves Bernardo, Rafael Oliveira Martins, Almir Custodio Batista Jr, Joao Victor Ataide Oliveira, Andrea Rodrigues Chaves, Boniek Gontijo Vaz
Summary: The imaging of biological tissues using mass spectrometry imaging (MSI) techniques allows for the visualization of the distribution of various metabolites, drugs, lipids, and glycans in complex samples. MSI methods like DESI-MSI and MALDI-MSI provide high sensitivity and the ability to evaluate/visualize multiple analytes in a single sample, overcoming limitations of classical microscopy techniques. This review discusses the application of DESI-MSI and MALDI-MSI in evaluating exogenous and endogenous molecules in biological samples, providing technical insights and recent research findings.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Mitsuru Tanaka, Keishiro Arima, Tomotaka Takeshita, Yuri Kunitake, Naoto Ohno, Miho Imamura, Toshiro Matsui
Summary: In this study, a GCB-LDI-MS method was developed for the simultaneous detection of taste- and odor-active compounds. This method was able to detect compounds that could not be detected by conventional matrix-assisted-LDI-MS, and it was also capable of detecting a variety of taste-active compounds in liquid samples.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Frederic Fournelle, Nidia Lauzon, Ethan Yang, Pierre Chaurand
Summary: Traditionally, MALDI IMS requires the deposition of an organic matrix, which often generates high background noise in the low mass range. LDI offers selective ionization with low background in the low mass range. This article discusses the advantages and disadvantages of solvent free and wet deposition of metals as LDI matrices and demonstrates the power of metal-assisted LDI for analyzing low molecular weight molecules in tissue sections.
MICROCHEMICAL JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Norihiro Mizoshita, Yuri Yamada, Masakazu Murase, Yasutomo Goto, Shinji Inagaki
Summary: In this study, a nanostructured organosilica substrate was designed and synthesized for efficient and rapid detection of peptides and small proteins. The surface functionality of the substrate was tuned at a molecular level, enabling both lowering surface free energy and introducing weak anchoring sites for biomolecules. The organosilica substrate showed great potential in detecting various compounds, including drugs and biomarkers for Alzheimer's disease.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Mingyi Du, Dong Chen, Yingying Chen, Yudi Huang, Lianlian Ma, Qingrong Xie, Yizhu Xu, Xinhai Zhu, Zilong Chen, Zhibin Yin, Hanhong Xu, Xinzhou Wu
Summary: In this study, SiO2@Au nanoshells were optimized for high-sensitivity LDI-MS analysis and a wide range of MSI applications, demonstrating superior performance in the detection and imaging of various small molecular metabolites. The method showed significant reduction in matrix interference, increased analyte coverage, lower detection limits, and good repeatability.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Norihiro Mizoshita, Yuri Yamada, Masakazu Murase, Yasutomo Goto, Shinji Inagaki
Summary: A nanostructured organosilica substrate is designed and synthesized for efficient and rapid detection of peptides and small proteins using laser desorption/ionization mass spectrometry. Surface functionality of the substrate is tuned to lower surface free energy and introduce weak anchoring sites for analyte molecules, enabling homogenous distribution and easy desorption upon laser irradiation. The substrate shows potential for easy detection of a wide range of biomolecules, including amyloid beta protein fragments as a biomarker for Alzheimer's disease.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Enhui Wu, Jia Yi, Baohong Liu, Liang Qiao
Summary: A rapid bacterial viability assessment and antimicrobial susceptibility testing method using LDI-MS technology was developed, showing higher efficiency than traditional methods. This method demonstrated high efficiency with different bacterial species and antibiotic drugs, and can be applied to human body fluid samples for antibiotic drug screening.
Article
Chemistry, Analytical
Yuanqing Luo, Xiaoyong Zhao, Zhan Gao, Huiwen Wang, Yaqing Liu, Cheng Guo, Yuanjiang Pan
Summary: Oligosaccharides play a crucial role in biological functions, and accurately identifying their structures is essential for a comprehensive understanding of their biological functions. This study successfully developed a nano-composite material that significantly improved the ionization efficiency of oligosaccharides, allowing for the differentiation and quantification of oligosaccharide isomers.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Xian-Na Wang, Bin Li
Summary: Gold nanoparticles/thiol-beta-cyclodextrin-functionalized TiO2 nanowires were prepared to enhance the performance of SALDI MS and MSI, showing superior detection sensitivity and repeatability.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Ari Chae, Gwanwon Lee, Dong-Yeun Koh, Cheol-Min Yang, Sungho Lee, Young-Kwan Kim
Summary: Carbon fiber (CNF), prepared from electrospun PAN fibers, shows high salt tolerance, sensitivity, and resolution for matrix-free LDI-MS analysis, making it a promising material for developing an efficient and universal platform for analyte analysis regardless of ionization modes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Hua Zhang, Lin Zhao, Jingjing Jiang, Jie Zheng, Li Yang, Yanyan Li, Jian Zhou, Tianshu Liu, Jianmin Xu, Wenhui Lou, Weige Yang, Lijie Tan, Weiren Liu, Yiyi Yu, Meiling Ji, Yaolin Xu, Yan Lu, Xiaomu Li, Zhen Liu, Rong Tian, Cheng Hu, Shumang Zhang, Qinsheng Hu, Yangdong Deng, Hao Ying, Sheng Zhong, Xingdong Zhang, Yunbing Wang, Hua Wang, Jingwei Bai, Xiaoying Li, Xiangfeng Duan
Summary: As cancer is increasingly seen as a metabolic disorder, serum metabolite profiling is proposed as a viable method for detecting cancer. In this study, a machine learning model using mass spectrometry-based liquid biopsy data is reported for pan-cancer screening and classification. The Multiplexed Nanomaterial-Assisted LDI for Cancer Identification (MNALCI) achieves high sensitivity and specificity for distinguishing cancers from healthy controls and accurately identifying the tissue of origin of tumors. This high throughput assay shows promising potential for non-invasive cancer diagnosis.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Peiqi Luo, Liping Wang, Lixia Jiang, Jie Sun, Yafeng Li, Huihui Liu, Caiqiao Xiong, Zongxiu Nie
Summary: Graphdiyne, a new carbon nanomaterial, has been utilized as a matrix in laser desorption ionization mass spectrometry for small molecule analysis, showing enhanced desorption and ionization efficiency. The use of Graphdiyne in LDI MS analysis can potentially improve the early diagnosis of liver cancer by identifying fatty acids as potential biomarkers.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Sherief A. Al Kiey, Walid Sharmoukh
Summary: Hybrid nanomaterials with dye encapsulated zeolitic imidazolate frameworks were synthesized and used as precursors for zinc oxide embedded nitrogen-doped carbon. The resulting ZnO@N-doped C exhibited high capacitance and excellent cycling stability, retaining 87.7% of the initial capacitance after 1000 galvanostatic charge-discharge cycles. The presence of a guest molecule like RhB significantly improved the capacitance of the carbonized ZIF-8 materials.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Aji P. Mathew
Summary: Cellulose-MOFs (CelloMOFs) are hybrid materials that combine cellulosic materials with metal-organic frameworks, offering a range of properties for applications in water remediation, air purification, gas storage, sensing/biosensing, and biomedicine. Their potential includes efficient adsorption for removing contaminants in water, catalytic applications for organic pollutants, air purification by removing greenhouse gases, and biomedical applications such as antibacterial and drug delivery. This review provides a synthesis, characterization, and overview of the applications of CelloMOFs materials, highlighting challenges and future prospects for researchers and scientists.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: In this article, the authors review the application of ZIF-based materials for CO2 removal via adsorption and catalysis. Various reaction types and recent membrane technologies are highlighted. The prospects for industrial applications and commercialization of ZIF-based materials are also briefly discussed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Hani Nasser Abdelhamid, Aji P. Mathew
Summary: This article reviews the applications of cellulose in the field of biomedicine, including antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. Cellulose-based materials possess customizable chemical, mechanical, and physical properties, making them suitable for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Mahmoud R. Saleh, Haitham M. El-Bery, Hani Nasser Abdelhamid
Summary: A wet-incipient impregnation method was used to synthesize hierarchical porous bimetallic (Co, Zn)-zeolitic imidazolate frameworks (ZIF-8)/TiO2 for efficient photocatalytic water splitting. Co@ZIF-8/TiO2 exhibited significantly higher photocatalytic efficiency than TiO2, with a hydrogen generation rate of 13 mmol·h(-1)·g(-1) and a 151-fold increase in catalytic performance. The hierarchical porous structure of Co@ZIF-8 facilitated charge transfer and provided efficient transport channels. This study demonstrates the potential of hierarchical porous metal-organic frameworks (MOFs) as support and promoter in photocatalytic applications of TiO2.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Ghada Abd-Elmonsef Mahmoud
Summary: In this study, copper-based metal-organic frameworks (MOFs) were used to synthesize copper oxide (CuO) embedded into carbon (CuO@C), which displayed high antifungal activity against four economic postharvest plant pathogens. The CuO@C nanoparticles inhibited the growth of the fungal species and decreased their enzyme activity, reducing the potentiality of fruit disease. The successful formation of CuO@C nanoparticles was confirmed using various characterization techniques.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid
Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Walid Sharmoukh, Hani Nasser Abdelhamid
Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: Metal-organic frameworks (MOFs) have shown great potential for industrial applications but current synthesis processes limit their use due to the powder form. A solvothermal method was used to grow copper-based MOFs onto a cotton textile, creating a material called CuBDC@Textile. CuBDC@Textile demonstrated excellent vapor sensing properties and high adsorption capacity for pyridine. This dual-functional material holds promise for further research on MOFs in textile applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Numa A. A. Althubiti, T. A. Taha, A. A. Azab, Hani Nasser Abdelhamid
Summary: The use of solid-state materials such as sodium borohydride for hydrogen storage and release can meet the requirements of the "Hydrogen Economy". This study investigated ZnO-based materials as catalysts for hydrogen release through the hydrolysis of NaBH4. The synthesis method produced nanocomposites consisting of ZnO-xTiO(2) and ZnO-xCeO(2) (x = 5 wt.% or 10 wt.%). Characterization techniques confirmed the phase purity and optical properties of the materials. The materials exhibited a high hydrogen generation rate and different activation energies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber
Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.
MOLECULAR CATALYSIS
(2023)
Article
Energy & Fuels
Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery
Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew
Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew
Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Ahmed I. A. Soliman, Aboel-Magd A. Abdel-Wahab, Hani Nasser Abdelhamid
Summary: This study reports the use of zeolitic imidazolate framework-8 (ZIF-8) and ZnO@N-doped C as effective adsorbents and photocatalysts for the removal of organic dyes from water. ZnO@N-doped C shows high degradation efficiency under UV exposure.
