期刊
MICROBIAL DRUG RESISTANCE
卷 23, 期 7, 页码 838-844出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2015.0339
关键词
carbapenemases; Klebsiella pneumoniae; Egypt; Escherichia coli; Serratia marcescens; Pseudomonas aeruginosa
资金
- Ministry of Higher Education, Egypt
- Japan Society for the Promotion of Science [PU14012]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [25460532]
- Grants-in-Aid for Scientific Research [25460532] Funding Source: KAKEN
The emergence and spread of carbapenem-resistant gram-negative bacteria poses a serious threat to human health worldwide. Currently, little is known about the molecular mechanisms underlying carbapenem resistance and their prevalence among gram-negative bacteria in Egypt. In this study, we analyzed carbapenemase production in gram-negative bacteria isolated from hospitalized patients in Egypt in 2014. All isolates were subjected to phenotypic and genotypic susceptibility testing for carbapenem resistance. Our results indicated a high level of carbapenem-resistant gram-negative bacteria in Egypt, with 50.8% of the isolates harboring at least one carbapenem resistance gene. OXA-48-like and NDM-1 were the most prevalent carbapenemases, being detected in 49.2%, and 47.7% of carbapenemase-positive isolates, respectively, whereas Verona integron-encoded metallo--lactamase (VIM) was detected in only 26.2% of carbapenemase-positive isolates. This study reports for the first time carbapenemase-producing Serratia marcescens, Morganella morganii, and bla(VIM-1-like)-producing Pseudomonas aeruginosa in Egypt. It is also the first demonstration of the coexistence of different carbapenemases, being detected in 21.5% of carbapenemase-positive isolates. Effective antibiotic supervision, regional surveillance, and early detection of carbapenemase producers are imperative to prevent their future spread to epidemic levels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据