Review
Gastroenterology & Hepatology
Raja Atreya, Britta Siegmund
Summary: Crohn's disease can affect any part of the gastrointestinal tract, and research has shown distinct differences between ileal and colonic Crohn's disease. Colonic Crohn's disease behavior overlaps with ulcerative colitis, highlighting the need for a more comprehensive understanding of inflammatory bowel diseases. Location and shared pathophysiology subtypes play an important role in the classification of these diseases.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Surgery
Tommaso Giuliani, Anthony Di Gioia, Stefano Andrianello, Giovanni Marchegiani, Claudio Bassi
Summary: The review on PD-CR treatment found a high rate of complications, including pancreatic fistula and colonic anastomotic leak. Surgical radicality and nodal status are crucial determinants of treatment outcomes.
UPDATES IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
Ryotaro Nakahara, Yuji Amano, Daisuke Murakami, Sayaka Ogawa, Tetsuro Ujihara, Tomoyuki Iwaki, Yasushi Katsuyama, Kenji Hayasaka, Hideaki Harada, Yasumasa Tada, Takafumi Yuki, Youichi Miyaoka, Yoshinori Kushiyama, Hirofumi Fujishiro, Shunji Ishihara
Summary: In Japanese patients, early colon cancer was more frequently found in those with colonic diverticulosis (CD) compared to those without CD. The presence of CD may be an important indicator for detecting colon cancer during colonoscopy examination.
DIGESTIVE ENDOSCOPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
S. Bhattacharya, K. Thankappan, S. Sukumaran, M. Mayadevi, D. Balasubramanian, S. Iyer
Summary: The study found that speech outcomes after resection and reconstruction of the oral tongue were significantly influenced by the volume of defects and their location, especially in class II and III defects. The results highlight the importance of considering volume and location in predicting speech outcomes post-surgery.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Business
Sam Tavassoli, Charlie Karlsson
Summary: The paper analyzes how the location of firms influences their innovation outcomes, particularly the complexity of the outcomes. Regional characteristics are found to have a positive association with firms introducing highly-complex innovation outcomes but not with those having less complex innovations. Internal resources and formal collaboration with external partners play a significant role for less complex innovators.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
Article
Gastroenterology & Hepatology
Enrique Rodriguez de Santiago, Maria Hernandez-Tejero, Liseth Rivero-Sanchez, Oswaldo Ortiz, Irene Garcia De La Filia-Molina, Jose Ramon Foruny-Olcina, Hector Miguel Marcos Prieto, Maria Garcia-Prada, Almudena Gonzalez-Cotorruelo, Miguel Angel De Jorge Turrion, Andrea Jimenez-Jurado, Carlos Rodriguez-Escaja, Andres Castano-Garcia, Ana Gomez Outomuro, Carlos Ferre-Aracil, Diego De-Frutos-Rosa, Maria Pellise
Summary: In this study of delayed postpolypectomy bleeding (DPPB) patients, it was found that nearly half do not require therapeutic intervention, with colonoscopy often being overused in this population. Independent risk factors for active bleeding were identified, helping to identify those who would benefit most from colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Niklas Kluemper, Damian J. Ralser, Romina Zarbl, Katrin Schlack, Andres Jan Schrader, Marc Rehlinghaus, Michele J. Hoffmann, Guenter Niegisch, Annemarie Uhlig, Lutz Trojan, Julie Steinestel, Konrad Steinestel, Ralph M. Wirtz, Danijel Sikic, Markus Eckstein, Glen Kristiansen, Marieta Toma, Michael Hoelzel, Manuel Ritter, Sebastian Strieth, Joerg Ellinger, Dimo Dietrich
Summary: The study found that CTLA4 promoter hypomethylation is associated with CTLA4 mRNA expression, lymphocyte infiltration, and poor prognosis in ccRCC. However, in patients with ICB-treated ccRCC, CTLA4 promoter hypomethylation predicted treatment response and favorable outcomes. Therefore, CTLA4 methylation may serve as a powerful predictive biomarker for immunotherapy response in metastatic RCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Tsukasa Masuda, Nobuyuki Tanaka, Kimiharu Takamatsu, Kyohei Hakozaki, Ryohei Takahashi, Tadatsugu Anno, Ryohei Kufukihara, Kazunori Shojo, Shuji Mikami, Toshiaki Shinojima, Kazuhiro Kakimi, Tatsuhiko Tsunoda, Eriko Aimono, Hiroshi Nishihara, Ryuichi Mizuno, Mototsugu Oya
Summary: This study compared the characteristics of tertiary lymphoid structures (TLS) between clear cell renal cell carcinoma (ccRCC) and bladder cancer, and found significant differences in TLS status, prognostic impact, maturity and spatial distribution, as well as the immune microenvironment surrounding TLSs between the two cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Francesca Palandri, Massimo Breccia, Camilla Mazzoni, Giuseppe Auteri, Elena Maria Elli, Malgorzata M. M. Trawinska, Nicola Polverelli, Mario Tiribelli, Giulia Benevolo, Alessandra Iurlo, Alessia Tieghi, Florian H. H. Heidel, Giovanni Caocci, Eloise Beggiato, Gianni Binotto, Francesco Cavazzini, Maurizio Miglino, Costanza Bosi, Monica Crugnola, Monica Bocchia, Bruno Martino, Novella Pugliese, Mattia Biondo, Marta Venturi, Luigi Scaffidi, Alessandro Isidori, Daniele Cattaneo, Mauro Krampera, Fabrizio Pane, Daniela Cilloni, Gianpietro Semenzato, Roberto M. M. Lemoli, Antonio Cuneo, Elisabetta Abruzzese, Daniela Bartoletti, Simona Paglia, Nicola Vianelli, Michele Cavo, Massimiliano Bonifacio, Giuseppe A. A. Palumbo
Summary: This study explored the prognostic factors of cytopenic myelofibrosis (MF) and found that high molecular risk mutations, intermediate 2/high Dynamic International Prognostic Score System, and intermediate 2/high Myelofibrosis Secondary to Polycythemia Vera and Essential Thrombocythemia Prognostic Model were associated with cytopenic MF. Patients with cytopenia received lower doses of ruxolitinib and had worse treatment outcomes, suggesting the need for alternative therapeutic strategies.
Article
Oncology
Ana Tergas, Holly G. Prigerson, Megan J. Shen, Andreea Dinicu, Alfred Neugut, Jason D. Wright, Dawn L. Hershman, Paul K. Maciejewski
Summary: This study found that immigrants are more likely to die in hospital settings, less likely to die at their preferred locations, and more likely to have poor quality of death compared to nonimmigrants.
Article
Genetics & Heredity
Florent Fuchs, Alexis Rodriguez, Eve Mousty, Denis Morin, Agathe Roubertie, Constance F. Wells, Olivier Prodhomme, Jean-Francois Benoist, Sophie Dreux, Jean-Michel Faure, Marjolaine Willems
Summary: Antenatal colonic hyperechogenicity may be a sign of lysinuria-cystinuria or other disorders with a more severe prognosis. This study identified that among fetuses with hyperechoic colon, approximately 63% had lysinuria-cystinuria, 8% had lysinuric protein intolerance, and 4% had hypotonia-cystinuria syndrome. These findings could modify the management of patients with hyperechogenic fetal colon.
PRENATAL DIAGNOSIS
(2023)
Article
Dermatology
Melissa de Almeida Correa Alfredo, Mariana Righetto de Re Lai, Luciane Donida Bartoli Miot, Gabriela Roncada Haddad, Aline Lutz Garcia, Helio Amante Miot
Summary: Eccrine poroma is a benign neoplasm of the terminal duct of the eccrine sweat glands, typically found on the extremities, presenting as normochromic or erythematous papules and nodules, up to 2 cm in diameter. Pigmented variants are rare, and differential diagnosis with porocarcinoma is crucial.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guorong Wang, Yue Fang, Zhiwei Wang, Zhengyu Jin
Summary: The study quantitatively assessed local colonic wall thickening using dual-layer spectral detector computed tomography, and found that IC and NIC values can be used to identify LCWT caused by colon neoplasia with satisfactory diagnostic value.
ACADEMIC RADIOLOGY
(2021)
Article
Oncology
Sabrina Piedimonte, Marcus Q. Bernardini, Avrilynn Ding, Stephane Laframboise, Sarah Elizabeth Ferguson, Genevieve Bouchard-Fortier, Lisa Avery, Taymaa May, Liat Hogen
Summary: This study validates the effectiveness of the Integrated Prediction Model in patients with advanced ovarian cancer, which triages patients to neoadjuvant chemotherapy or primary cytoreductive surgery based on a 4-step algorithm.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Clinical Neurology
Clara Kwon Starkweather, Sarah K. Bick, Jeffrey M. McHugh, Darin D. Dougherty, Ziv M. Williams
Summary: Patients who respond well to cingulotomy tend to have lesions located more superiorly and posteriorly along the cingulate sulcus, with a greater coverage of a posterior subregion of BA32 compared to nonresponders.
JOURNAL OF NEUROSURGERY
(2022)
