Article
Orthopedics
Zhaoqi Lu, Minling Huang, Haixiong Lin, Gaoxiang Wang, Huilin Li
Summary: The study investigated the active components, signaling pathways, and potential mechanisms of Liuwei Dihuang pill (LDP) in the treatment of diabetic osteoporosis using network pharmacology approaches. The results indicate that LDP may treat diabetic osteoporosis through multiple targets and signaling pathways.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Qingchan Wang, Ping Huang, Chenjie Xia, Danqing Fu
Summary: This study explored the pharmacological mechanisms of Liuwei Dihuang (LWDH) Pill against postmenopausal osteoporosis (PMOP) using a network pharmacological strategy. The results showed that LWDH Pill exerts anti-PMOP effects by regulating multiple biological processes such as cell proliferation and apoptosis, oxidative stress, inflammation, and angiogenesis. Furthermore, several signaling pathways that may be involved in modulating these biological processes were identified.
Article
Plant Sciences
Meizhong Peng, Meiling Yang, Yan Lu, Shan Lin, Huajian Gao, Lingling Xie, Bin Huang, Daxin Chen, Aling Shen, Zhiqing Shen, Jun Peng, Jianfeng Chu
Summary: Huoxin Pill (HXP) can suppress ISO-induced cardiac fibrosis and CFs transdifferentiation by inhibiting the activation of the TGF-beta/Smads pathway, potentially serving as a new therapeutic tool for cardiac fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Orthopedics
Fuping Zhu, Wuping Li, Linhua Wang, Bing Dai, Zongyi Liu, Hang Wu, Ting Deng
Summary: Quercetin, the major constituent of Liuwei Dihuang Pill (LP), alleviated the progression of postmenopausal osteoporosis (PMOP) by activating the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Mathematical & Computational Biology
Shi Shu, Yue Zhang, Qian Wang, Pengyu Tao, Zhijie Li, Zhongju Xu, Haiying Lu, Lin Shi
Summary: Diabetic nephropathy (DN) is a significant factor causing end-stage renal disease, and current treatments are not ideal. The study found that Liuwei Dihuang pill (LDP) attenuated oxidative stress and prevented renal fibrosis by inhibiting the TGF-beta/Smad2/3 pathway.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiaodong Zhu, Xiaogang Shen, Bo Lin, Jiaxi Fang, Juan Jin, Qiang He
Summary: This study found that Liuwei Dihuang pills (LWDHW) can improve the damage to podocytes caused by IgA nephropathy (IgAN) by regulating the PI3K-Akt-mTOR pathway and inhibiting autophagy. Animal experiments confirmed that LWDHW can reduce the red blood cell count and urinary protein, and improve the pathological changes in kidney tissue.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematical & Computational Biology
Kai Zhang, Junhua Guo, Yong Zhu, Rui Zhang
Summary: Zhibai Dihuang Pill (ZDP) improves male infertility induced by Ureaplasma urealyticum (UU) infection by suppressing inflammation and oxidative stress through the mitogen-activated protein kinase (MAPK) signaling pathway.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Li Wang, Hong-Lian Wang, Tong-Tong Liu, Hui-Yao Lan
Summary: This review discusses the diverse roles and signaling mechanisms of TGF-beta in diabetic nephropathy, focusing on latent versus active TGF-beta 1, TGF-beta receptors, and downstream Smad signaling molecules. The regulatory mechanisms of TGF-beta/Smad signaling in the development of DN, including Smad-dependent non-coding RNAs, are also dissected. Finally, potential therapeutic strategies for DN targeting TGF-beta signaling with various approaches are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Xi Xie, Hongjun Lou, Ye Shi, Guang Gan, Hanqing Deng, Xinwei Ma, Mingfang Meng, Xi Gao
Summary: The potential mechanism of Liuwei Dihuanng pill in the treatment of chronic kidney disease (CKD) was investigated using network pharmacology. The main components of Liuwei Dihuang pill were identified as quercetin, stigmasterol, kaempferol, beta-sitosterol, and others, with JUN, AKT1, TP53 as the main targets. This study provides a theoretical basis and evidence for further experimental research.
Review
Medicine, General & Internal
Zhongbiao Wu, Zhongyan Zhu, Jian Cao, Weikun Wu, Shiping Hu, Chengcheng Deng, Qiang Xie, Xinmei Huang, Chengkun You
Summary: This study explored the potential pharmacological mechanism of Liuwei Dihuang Pill in treating tinnitus using network pharmacology and molecular docking. The results indicated that the core components of Liuwei Dihuang Pill may act on multiple core targets, involving anti-inflammatory, improved blood circulation, increased cochlear blood flow, and prevention of hair cell damage.
Article
Endocrinology & Metabolism
Nian Ding, Chenghong Zheng
Summary: This study established a rat diabetes model and used Jiangtang Tongmai Prescription (JTTMP) as an intervention treatment to explore its restorative effect on diabetic lung injury. The results showed that JTTMP could activate the SnoN and TGF-beta 1/Smads signaling pathway to repair the damage caused by diabetes in the lungs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Physiology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study reveals that Qishen Yiqi dripping pill exerts renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats, as evidenced by reduced levels of serum markers and improved kidney histology and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xuechun Sun, Yu Yang, Xiaodan Sun, Huali Meng, Wenhao Hao, Jialin Yin, Fuzhe Ma, Xin Guo, Lei Du, Lei Sun, Hao Wu
Summary: The current study investigated the preventive effect of krill oil (KO) on diabetic nephropathy (DN) and found that it can prevent DN by suppressing the TGF-beta 1 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Vjera Mihaljevic, Milorad Zjalic, Tomislav Kizivat, Tea Omanovic Kolaric, Martina Smolic, Edi Rodak, Marina Covic, Lucija Kuna, Robert Smolic, Aleksandar Vcev, Ines Bilic Curcic
Summary: This study investigated the effects of empagliflozin on diabetic nephropathy at the cellular level. The results showed that empagliflozin can reduce oxidative stress-induced damage and inflammation by activating the Akt/GSK-3 signaling pathway and downregulating TGF-beta 1 expression.