Article
Cell Biology
Ying Ding, Dao-yang Zhou, Hong Yu, Tao Zhu, Feng Guo, Yang He, Xiu-liu Guo, Yong-jun Lin, Yu-jiao Liu, Yun-song Yu
Summary: In septic acute kidney injury, the long noncoding RNA 9935 plays a crucial role in inhibiting the apoptosis of renal tubular epithelial cells by disrupting HuR-mediated Tp53 mRNA stability, thereby slowing down the progression of the disease.
CELL DEATH & DISEASE
(2021)
Article
Surgery
Dara L. Horn, Michael Mindrinos, Kirsten Anderson, Sujatha Krishnakumar, Chunlin Wang, Ming Li, Jill Hollenbach, Grant E. O'Keefe
Summary: This study utilized next-generation sequencing techniques to examine the associations between immunogenetic factors and post-traumatic sepsis and septic shock. The findings indicate novel associations with class I HLA variants, implicating adaptive immunity in post-traumatic sepsis. These results are a step towards developing a panel of genetic markers assessing risk of infection-related complications, as we move towards more personalized medicine.
Article
Biology
Vasiliki Tsolaki, George E. Zakynthinos, John Papanikolaou, Vasileios Vazgiourakis, Kyriaki Parisi, George Fotakopoulos, Demosthenes Makris, Epaminondas Zakynthinos
Summary: This study compared the treatment of severe septic cardiomyopathy (SCM) with levosimendan and the best available therapy. The results showed that patients receiving levosimendan had better recovery of cardiac function and a decrease in lactate levels, although there was no statistically significant difference in survival rates. This suggests that levosimendan treatment may be effective in patients with severe SCM.
Article
Critical Care Medicine
John W. Keyloun, Ross Campbell, Bonnie C. Carney, Ruoting Yang, Stacy-Ann Miller, Leanne Detwiler, Aarti Gautam, Lauren T. Moffatt, Rasha Hammamieh, Marti Jett, Jeffrey W. Shupp
Summary: Burn injury induces an early proinflammatory immune response followed by shutdown of immune pathways. This study aims to characterize the blood transcriptome after burn injury. Analysis of patient blood samples revealed differential gene expression and enrichment of immune/inflammatory pathways based on burn injury severity.
JOURNAL OF BURN CARE & RESEARCH
(2022)
Article
Critical Care Medicine
Jineel H. Raythatha, Harleen Aulakh, Stephen Yang, Calvin Mok, S. Soundappan
Summary: The Pediatric Age-adjusted Shock Index (SIPA) in combination with the Glasgow Coma Scale (GCS) can better predict the outcomes of trauma patients, especially when calculated upon arrival. Combining SIPA with GCS has potential clinical applications for predicting the occurrence of major trauma and other clinical conditions.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
Veronika Tomaskova, Alexandra Mytnikova, Marcela Hortova Kohoutkova, Ondrej Mrkva, Monika Skotakova, Michal Sitina, Katerina Helanova, Jan Fric, Jiri Parenica, Vladimir Sramek, Martin Helan
Summary: This study examined the ability of sEng to predict mortality and its correlation with other clinical characteristics in septic shock patients and severe COVID-19 patients. The results showed that sEng was not predictive of mortality or correlated with organ dysfunction markers in COVID-19 patients. However, in septic shock patients, sEng levels were significantly higher in patients with early mortality and correlated with signs of circulatory failure.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Christian Zanza, Tatsiana Romenskaya, Fabrizio Racca, Eduardo Rocca, Fabio Piccolella, Andrea Piccioni, Angela Saviano, George Formenti-Ujlaki, Gabriele Savioli, Francesco Franceschi, Yaroslava Longhitano
Summary: Despite preventive measures and innovations in trauma systems, trauma still remains a leading cause of death in adults. Trauma-induced coagulopathy (TIC) is a multifactorial condition resulting from dysregulated coagulation, altered fibrinolysis, endothelial dysfunction, platelet dysfunction, and inflammatory responses. This review focuses on the pathophysiology, early diagnosis, and treatment of TIC, including the use of pharmaceutical hemostatic agents. While our understanding of TIC has increased, ongoing studies are needed to answer remaining questions and improve outcomes for trauma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Marcela Hortova-Kohoutkova, Monika Skotakova, Isaac G. Onyango, Miriam Slezakova, Roman Panovsky, Lukas Opatril, Peter Slanina, Marco De Zuani, Ondrej Mrkva, Ivana Andrejcinova, Petra Laznickova, Martina Dvoncova, Alexandra Mytnikova, Vaughn Ostland, Michal Sitina, Gorazd B. Stokin, Vladimir Sramek, Marcela Vlkova, Martin Helan, Jan Fric
Summary: This study investigated the dynamics of iron regulation in different clinical settings and determined the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity. The results showed that hepcidin levels reflect overall immune cell activation driven by intrinsic stimuli, while ferritin levels are more strongly influenced by pathogen-induced inflammation. Furthermore, the hepcidin-to-ferritin ratio has the ability to predict mortality in septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Immunology
Chunlin Xiang, Xiaoxiao Wu, Youkang Wei, Tianlong Li, Xuemei Tang, Yi Wang, Xiaoqin Zhang, Xiaobo Huang, Yiping Wang
Summary: This article reports a rare case of severe septic shock caused by human parvovirus B19 infection after cardiac surgery. The virus can lead to septicemia, rash, fever, and other symptoms, especially in immunocompromised patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Critical Care Medicine
Jing Yue, Ronghao Zheng, Huiping Wei, Jie Li, Jiannan Wu, Ping Wang, Hui Zhao
Summary: The study found that in pediatric patients with septic or severe infection shock, the no bolus group showed significantly lower mortality rates at 48 hours, especially in cases of malaria. Similar results were observed with colloids and crystalloids solution treatment in malaria shock patients.
Article
Emergency Medicine
Chih-Yuan Fu, Francesco Bajani, Marissa Bokhari, Frederick Starr, Thomas Messer, Matthew Kaminsky, Andrew Dennis, Victoria Schlanser, Justin Mis, Stathis Poulakidas, Faran Bokhari
Summary: In elderly patients with blunt abdominal trauma (BAT), age itself has an independent and deleterious effect on mortality, while age-associated comorbidity does not. Older patients had higher mortality rates, complication rates, and longer lengths of hospital and ICU stays compared to younger patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Surgery
Samer Asmar, Muhammad Zeeshan, Muhammad Khurrum, Jorge Con, Mohamad Chehab, Letitia Bible, Rifat Latifi, Bellal Joseph
Summary: The study on Delta SI in pediatric trauma patients found that Delta SI can predict mortality. There are variations in vital signs among different age groups of children, but Delta SI inherently accounts for this variation.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Emergency Medicine
Joseph D. Lykins, Hani I. Kuttab, Erron M. Rourke, Michelle D. Hughes, Eric P. Keast, Jason A. Kopec, Brooke L. Ward, Natasha N. Pettit, Michael A. Ward
Summary: Factors associated with delayed administration of the second dose of antibiotics include ED boarding, antibiotics requiring more frequent dosing, receiving 30 mL/kg of fluids within three hours, and renal failure. Delays in second-dose administration were not found to be associated with increased mortality or other outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Domenico Scrutinio, Pietro Guida, Maria Aliani, Giorgio Castellana, Patrizia Guido, Mauro Carone
Summary: This study found that comorbidities in patients with severe OSAS are closely related to all-cause mortality, with age and comorbidities being key predictors of death. Recursive-partitioning analysis showed that patients with a combination of CKD and CVD or COPD have the highest mortality risk.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Psychology, Clinical
Guillaume Fond, Vanessa Pauly, Marc Leone, Veronica Orleans, Alexandra Garosi, Christophe Lancon, Pascal Auquier, Karine Baumstarck, Pierre-Michel Llorca, Laurent Boyer
Summary: This study examined whether bipolar disorder (BD) patients with COVID-19 have an increased risk of mortality. It found that patients with BD had a higher mortality rate, which was more pronounced in younger and socioeconomically disadvantaged patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anesthesiology
Malik Haddam, Laura Kubacsi, Sophie Hamada, Anatole Harrois, Arthur James, Olivier Langeron, Mathieu Boutonnet, Mathilde Holleville, Delphine Garrigue, Marion Leclercq, Jean-Luc Hanouz, Julien Pottecher, Gerard Audibert, Mickael Cardinale, Helene Vinour, Laurent Zieleskiewicz, Noemie Resseguier, Marc Leone
Summary: This study aimed to determine the prevalence of WLST decisions in trauma ICU patients. The results showed that 6% of the trauma patients made WLST decisions. Factors associated with WLST decisions included age, medical history, trauma severity, and neurological status.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Clinical Neurology
Marine Mulatero, Mohamed Boucekine, Olivier Felician, Salah Boussen, Gilles Kaplanski, Pascal Rossi, Philippe Parola, Andreas Stein, Philippe Brouqui, Jean Christophe Lagier, Marc Leone, Elsa Kaphan
Summary: This study aimed to determine the precise and most effective treatment modalities for herpetic encephalitis. The results showed that poor outcome was associated with several factors, including persistence of symptoms, superinfection, status epilepticus, and length of stay in intensive care unit. A statistical decision tree was constructed to prioritize treatment management, emphasizing the importance of patient's weight and the average daily acyclovir dose actually administered. It was concluded that modifying acyclovir management, particularly for low-weight patients, could improve the treatment outcome.
JOURNAL OF NEUROLOGY
(2022)
Article
Cell & Tissue Engineering
Lucas Guillo, Fanny Grimaud, Fanny Houser, Caroline Prost, Elisabeth Jouve, Cecile Philandrianos, Maxime Abellan, Julie Veran, Carine Visee, Laura Beyer-Berjot, Ariadne Desjeux, Francoise Dignat-George, Marc Leone, Jean-Charles Grimaud, Florence Sabatier, Melanie Serrero, Jeremy Magalon
Summary: This study evaluated the long-term efficacy of combined treatment with autologous adipose-derived stromal vascular fraction (ADSVF) and microfat in Crohn's disease perianal fistulas. The results showed that the safety and efficacy of this treatment were maintained at 3 years, leading to long-lasting healing effect.
STEM CELL RESEARCH & THERAPY
(2022)
Editorial Material
Anesthesiology
Marc Leone, Ines Lakbar, Alexandre Lopez, Claire Zunino, Ignacio Martin Loeches
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Review
Critical Care Medicine
Ines Lakbar, Louis Delamarre, Sharon Einav, Marc Leone
Summary: This review focuses on critically ill infective endocarditis (IE) patients during perioperative and intensive care, and highlights the changing epidemiology of IE towards elderly and frail patients. ICU patients are at a higher risk of developing IE due to their pro-inflammatory state and indwelling catheters. Although cardiac imaging techniques have improved for the diagnosis of EI, their applicability to ICU patients is still limited. The review also discusses new developments in antibiotic treatment and adjunctive therapies. The lack of evidence on ICU patients with IE emphasizes the critical importance of multidisciplinary decision-making and further research.
CURRENT OPINION IN CRITICAL CARE
(2022)
Correction
Critical Care Medicine
Adrien Bougle, Sophie Tuffet, Laura Federici, Marc Leone, Antoine Monsel, Thomas Dessalle, Julien Amour, Claire Dahyot-Fizelier, Francois Barbier, Charles-Edouard Luyt, Olivier Langeron, Bernard Cholley, Julien Pottecher, Tarik Hissem, Jean-Yves Lefrant, Benoit Veber, Matthieu Legrand, Alexandre Demoule, Pierre Kalfon, Jean-Michel Constantin, Alexandra Rousseau, Tabassome Simon, Arnaud Foucrier
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Marc Leone, Cassia Righy, Pedro Povoa
INTENSIVE CARE MEDICINE
(2022)
Article
Emergency Medicine
Matthieu Vasse, Marc Leone, Laurent Boyer, Pierre Michelet, Yvain Goudard, Michael Cardinale, Raphael Paris, Jean Philippe Avaro, Pascal Alexandre Thomas, Henri de Lesquen
Summary: This study aimed to assess compliance with protocols in penetrating thoracic trauma on admission to a level I trauma centre and determine whether compliance impacts morbidity and mortality. The implementation of a trauma system was associated with better compliance to European recommendations and improved outcomes for severe trauma patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Surgery
Mathieu Rouy, Clement Julien, Ilyes Hamouda, Damien Massalou, Thierry Bege, Marc Leone, Stephane Berdah, Sandrine Barbois, Edouard Girard, Catherine Arvieux, David Jeremie Birnbaum
Summary: This study aimed to determine the predictive factors and risk-stratified score for non-operative management (NOM) failure in blunt liver trauma (BLT). The results showed that the presence of hemoperitoneum, angioembolization, and severe liver injury were independent predictive factors of NOM failure. A risk score based on these three factors can stratify the risk of NOM failure in BLT and assist in providing appropriate levels of medical surveillance for each patient.
UPDATES IN SURGERY
(2022)
Review
Critical Care Medicine
Ines Lakbar, Mariachiara Ippolito, Aviv Nassiri, Louis Delamarre, Philippe Tadger, Marc Leone, Sharon Einav
Summary: There is currently no consensus on whether females receive less advanced cardiac life support than males or whether females have a survival advantage over males after cardiopulmonary resuscitation. The study found that, although females had a lower likelihood of survival than males in unadjusted analysis, there was no significant difference after adjustment. However, the results were associated with substantial heterogeneity, raising concerns about potential inequalities.
ANNALS OF INTENSIVE CARE
(2022)
Article
Medicine, General & Internal
Ines Gragueb-Chatti, Herve Hyvernat, Marc Leone, Geoffray Agard, Noemie Peres, Christophe Guervilly, Mohamed Boucekine, Dany Hamidi, Laurent Papazian, Jean Dellamonica, Alexandre Lopez, Sami Hraiech
Summary: In patients with COVID-19 associated respiratory failure, approximately 46% of those who experienced a first episode of VAP had recurrences. These recurrences were mainly relapses and were associated with longer durations of MV and ICU stays, but not with increased mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Ines Lakbar, Sharon Einav, Nathalie Lalevee, Ignacio Martin-Loeches, Bruno Pastene, Marc Leone
Summary: Sex and gender dimorphisms are observed in various diseases, including sepsis and septic shock, with a higher prevalence in men. Animal models indicate that females and males have different responses to pathogens, mainly due to sex polarization of intracellular pathways. Sex hormones play a role in this polarization, but further research is needed to investigate other factors.
Review
Microbiology
Alexis Garduno, Rachael Cusack, Marc Leone, Sharon Einav, Ignacio Martin-Loeches
Summary: It is evident that delayed admission of sepsis and septic shock patients to hospitals contributes to poor outcomes and high fatalities worldwide. The current diagnostic procedure is inaccurate and often delayed, while the immune response in sepsis involves cytokine storm and changes in immune cell proportions. This review explores the potential use of multi-omics data integration and immunological profiling at the single-cell level to define endotypes in sepsis and septic shock, as well as the parallels with cancer and immunosuppression, sepsis-induced cardiomyopathy, and endothelial damage. The added value of transcriptomic-driven endotypes for inferring regulatory interactions and measuring clinical response in ICU will also be assessed.
Article
Infectious Diseases
Matthieu Rossi, Louis Delamarre, Gary Duclos, Ines Lakbar, Emmanuelle Hammad, Charlotte Arbelot, Laurent Zieleskiewicz, Marc Leone
Summary: Compliance with the PCT protocol for VAP treatment was assessed in this study, with a compliance rate of 58%. Noncompliance was mainly due to lack of PCT measurements. Higher compliance was observed in medical patients and those admitted for SARS-CoV-2 infection, while compliance regarding antibiotic therapy interruption based on PCT was lower on weekends and holidays.