Article
Genetics & Heredity
Ruyue Chen, Qiang Lin, Yun Zhu, Yunyan Shen, Qinying Xu, Hanyun Tang, Ningxun Cui, Lu Jiang, Xiaomei Dai, Weiqing Chen, Xiaozhong Li
Summary: The article reports successful cases of using PD-1 inhibitor Sintilimab to treat CAEBV and EBV-HLH. Among the three patients, two had CAEBV and one had EBV-HLH. After treatment, the clinical symptoms of the patients improved significantly, and the EBV-DNA load decreased significantly. The study supports the efficacy of PD-1 targeted therapy in certain patients with CAEBV and EBV-HLH and suggests that Sintilimab may provide a cure without HSCT.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Cell Biology
Zhaoxuan Zhang, Wei Wang, Yuan Li, Zhouyi Xu, Haibo Wu, Zhe Wang
Summary: This study reports two cases of nodal T follicular helper cell lymphoma (nTFHL) showing Epstein-Barr virus (EBV) positivity in the neoplastic cells, as well as unique gene mutations and poor prognosis. This finding expands the currently recognized spectrum of EBV-positive lymphomas to include rare cases of nTFHL.
Review
Virology
Yi Tian Png, Audrey Zhi Yi Yang, Mei Ying Lee, Magdalene Jahn May Chua, Chwee Ming Lim
Summary: The vast majority of the global population are asymptomatic carriers of Epstein-Barr Virus (EBV), which can lead to EBV-related cancers like Nasopharyngeal Carcinoma (NPC). NPC is highly prevalent in Southern China and Southeast Asia, with a lack of effective treatment for recurrent disease in some patients. Research on the role of Natural Killer (NK) cells in clearing EBV-infected cells and evasion by EBV in NPC is crucial for developing more effective therapies.
Article
Oncology
Yue Song, Jingshi Wang, Yini Wang, Lin Wu, Zhao Wang
Summary: Research has shown that including etoposide in the initial treatment of LAHS can significantly improve remission and survival rates, especially benefiting EBV negative patients.
CANCER BIOLOGY & THERAPY
(2021)
Article
Immunology
Ailin Zhao, Jinrong Yang, Meng Li, Linfeng Li, Xinai Gan, Jie Wang, He Li, Kai Shen, Yunfan Yang, Ting Niu
Summary: In EBV-positive LAHS patients, those with T/NK cell lymphoma were significantly younger and had lower fibrinogen and C-reactive protein levels compared to those with B cell lymphoma. Patients who received combined anti-HLH and anti-lymphoma treatment had higher ORR and OS. Elevated alanine aminotransferase level was an independent risk factor for the prognosis of EBV-positive LAHS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Virology
Julien Lupo, Mansour Tsougaev, Stephane Blachier, Guillaume Chovelon, Aurelie Truffot, Corentin Leroy, Joris Giai, Olivier Epaulard, Raphaele Germi, Patrice Morand
Summary: This study compared the performance of two immunoassays for detecting serological markers of EBV infection. The results showed a high agreement between the two methods, but differences were found in sensitivity and detection rates for early primary infection and past infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Oded Shamriz, Deepak Kumar, Jenny Shim, Michael Briones, Maa-Ohui Quarmyne, Satheesh Chonat, Laura Lucas, Holly Edington, Michael H. White, Advay Mahajan, Sunita Park, Shanmuganathan Chandrakasan
Summary: T cell-EBV-HLH is found in the USA, especially among non-Asian populations such as Hispanics. Most patients do not have primary HLH gene defects, but disease severity and treatment response are correlated. The majority of patients respond well to immunosuppressive therapy.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Oncology
Yanxia He, Yan Gao, Liqin Ping, Haixia He, Cheng Huang, Bing Bai, Xiaoxiao Wang, Zhiming Li, Qingqing Cai, Yuhua Huang, Xueyi Pan, Wenbin Zeng, Yanan Liu, Huiqiang Huang
Summary: This study evaluated the efficacy and toxicity of anti-PD-1 antibody-based treatment in patients with NK/T-LAHS. The results showed that the combination of anti-PD-1 antibody and chemotherapy improved the overall response rate and was well tolerated.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Hematology
Cristina Venturini, Charlotte J. Houldcroft, Arina Lazareva, Fanny Wegner, Sofia Morfopoulou, Persis J. Amrolia, Zainab Golwala, Anupama Rao, Stephen D. Marks, Jacob Simmonds, Tetsushi Yoshikawa, Paul J. Farrell, Jeffrey Cohen, Austen J. Worth, Judith Breuer
Summary: CAEBV is a rare disease characterized by persistent EBV infection, with defective EBV genomes found in East Asian patients. In this study, EBV deletions were observed in blood samples from CAEBV patients but not in saliva samples, and these deletions were lost over time after successful treatment. This suggests that CAEBV is associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Shuyan Yao, Zhili Jin, Lingbo He, Ruoxi Zhang, Menghan Liu, Zhengjie Hua, Zhao Wang, Yini Wang
Summary: The study showed significant differences in pathological types, clinical characteristics, and prognosis between lymphoma patients with or without LAHS. Age, platelet count, IPI, history of lymphoma, and lack of HLH remission were identified as independent risk factors for the prognosis of NHL-LAHS patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Zanelli Magda, Paola Parente, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Alessandra Bisagni, Illuminato Carosi, Domenico Trombetta, Luca Mastracci, Linda Ricci, Saverio Pancetti, Giovanni Martino, Giuseppe Broggi, Rosario Caltabiano, Alberto Cavazza, Stefano Ascani
Summary: Intravascular NK/T-cell lymphoma is a rare lymphoma with unique clinical, pathological, and molecular features, posing challenges in diagnosis and treatment. EBV infection is closely associated with the aggressive behavior of the disease, and immune checkpoint inhibitors may offer promising therapeutic results.
Article
Immunology
Jing Zhang, Shuchao Qin, Ze Jin, Qingqing Chen, Lingxiao Xing, Tonglu Qiu, Yi Xia, Jinhua Liang, Huayuan Zhu, Li Wang, Lei Fan, Wei Xu, Jianyong Li, Yi Miao
Summary: The role of circulating Epstein-Barr virus (EBV) DNA in lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) was evaluated. High EBV load was identified as a risk factor for lymphoma-associated HLH and a prognostic index was established to predict outcomes.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Hannes Vietzen, Philipp B. Staber, Sarah M. Berger, Philippe L. Furlano, Laura M. Kuehner, Simone Lubowitzki, Alexander Pichler, Robert Strassl, Jan J. Cornelissen, Elisabeth Puchhammer-Stoeckl
Summary: EBV infection has recurrent reactivations in most adults, but only a minority progress to EBV+ Hodgkin or non-Hodgkin lymphomas. This study found that EBV+ lymphoma patients have significantly higher expression of HLA-E*0103/0103 genotype and impaired NKG2C+ NK cell responses, and blocking NKG2A with monoclonal antibodies can effectively control the growth of EBV+ tumor cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Lu Yan, Yuan Wang, Zhi-Zhi Wang, Yan-Ting Rong, Lin-Lin Chen, Qian Li, Ting Liu, Yong-Heng Chen, Yan-Dong Li, Zhao-Hong Huang, Jie Peng
Article
Immunology
Linlin Chen, Yiyou Zou, Jie Peng, Fanggen Lu, Yani Yin, Fujun Li, Junwen Yang
JOURNAL OF IMMUNOLOGY RESEARCH
(2015)
Article
Medicine, General & Internal
Junwen Yang, Shuijiao Chen, Linlin Chen, Miao Ouyang, Fujun Li
Article
Cell & Tissue Engineering
Hongyun Wei, Xiaowei Liu, Chunhui Ouyang, Jie Zhang, Shuijiao Chen, Fanggen Lu, Linlin Chen
CURRENT STEM CELL RESEARCH & THERAPY
(2017)
Review
Oncology
Hongyun Wei, Linlin Chen, Guanghui Lian, Junwen Yang, Fujun Li, Yiyou Zou, Fanggen Lu, Yani Yin
Article
Gastroenterology & Hepatology
Xuefeng Li, Xiaowei Liu, Yiyou Zou, Chunhui Ouyang, Xiaoping Wu, Minghuan Zhou, Linlin Chen, Lingjuan Ye, Fanggen Lu
DIGESTIVE DISEASES AND SCIENCES
(2011)
Article
Gastroenterology & Hepatology
Lin-Lin Chen, Xue-Hong Wang, Yi Cui, Guang-Hui Lian, Jie Zhang, Chun-Hui Ouyang, Fang-Gen Lu
WORLD JOURNAL OF GASTROENTEROLOGY
(2009)
Article
Gastroenterology & Hepatology
Lin-Lin Chen, Yi-You Zou, Fang-Gen Lu, Fu-Jun Li, Guang-Hui Lian
WORLD JOURNAL OF GASTROENTEROLOGY
(2013)
Article
Cell Biology
Yunzhan Zhang, Jia-Zhong Cai, Lan Xiao, Hee K. Chung, Xiang-Xue Ma, Lin-Lin Chen, Jaladanki N. Rao, Jian-Ying Wang
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Tianyu Liu, Suyu He, Linlin Chen, Kai Jiang, Xiaomei Ding, Xiquan Wang, Ying Bi
Article
Nutrition & Dietetics
Qian Liu, Xiaomei Zhang, Zichun Li, Ying Chen, Yani Yin, Zhaoxia Lu, Miao Ouyang, Linlin Chen
Summary: This study investigates the impact of diverse diet conditions during early life on intestinal flora structure and susceptibility to inflammatory bowel disease (IBD). The findings indicate that a maternal high-protein diet negatively regulates the diversity of offspring mice's intestinal flora and increases their susceptibility to IBD.
Editorial Material
Gastroenterology & Hepatology
Zhaoxia Lu, Linlin Chen, Yuanyuan Zhou, Yani Yin, Xiaojuan Jing, Miao Ouyang
Article
Oncology
Guanghui Lian, Shuijiao Chen, Miao Ouyang, Fujun Li, Linlin Chen, Junwen Yang
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2019)
Article
Oncology
Guanghui Lian, Fujun Li, Yani Yin, Linlin Chen, Junwen Yang