The Search for Potent, Small-Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat

Docking Studies of Glutamine Valproic Acid Derivative (S)-5- amino-2-(heptan-4-ylamino)-5-oxopentanoic Acid (Gln-VPA) on HDAC8 with Biological Evaluation in HeLa Cells

(2016) F. Martínez-Ramos et al.   Anti-Cancer Agents in Medicinal Chemistry

Is there any therapeutic value for the use of histone deacetylase inhibitors for chronic pain?

(2016) Wei Wang et al.   BRAIN RESEARCH BULLETIN

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

Epigenetic Drugs for Multiple Sclerosis

(2016) Jacob Peedicayil   Current Neuropharmacology

In Silico Approach to Finding New Active Compounds from Histone Deacetylase (HDAC) Family

(2016) Arry Yanuar et al.   CURRENT PHARMACEUTICAL DESIGN

Inside HDACs with more selective HDAC inhibitors

(2016) Joëlle Roche et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients

(2016) Jafar Mohseni et al.   JOURNAL OF HUMAN GENETICS

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

(2016) Tino Heimburg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of New Inhibitors for Human SIRT1: An in-silico Approach

(2016) Balasundaram Padmanabhan et al.   Medicinal Chemistry

HDAC6 finally crystal clear

(2016) Yanli Liu et al.   Nature Chemical Biology

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

(2016) Yang Hai et al.   Nature Chemical Biology

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

(2016) Yasuyuki Miyake et al.   Nature Chemical Biology

The potential use of histone deacetylase inhibitors in the treatment of depression

(2016) Manabu Fuchikami et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy

(2016) Fatima el Bahhaj et al.   Theranostics

Virtual screening and experimental validation of novel histone deacetylase inhibitors

(2016) Yan-xin Huang et al.   BMC Pharmacology & Toxicology

Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor

(2015) Jingwei Zhou et al.   ACS Chemical Biology

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors

(2015) Edina C. Wang et al.   BIOMATERIALS

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

(2015) Minghong Ni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite

(2015) Giuseppe Giannini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma

(2015) T. J. Galloway et al.   CLINICAL CANCER RESEARCH

Selective Inhibitors of Zinc-Dependent Histone Deacetylases. Therapeutic Targets Relevant to Cancer

(2015) Jakub Kollar et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Advances in Computer-Assisted Structure-Based Identification and Design of Histone Deacetylases Inhibitors

(2015) Shagun Krishna et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Selective Histone Deacetylase Inhibitors with Anticancer Activity

(2015) Nan Ma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

How the flexibility of human histone deacetylases influences ligand binding: an overview

(2015) Nathalie Deschamps et al.   DRUG DISCOVERY TODAY

Histone deacetylases: structural determinants of inhibitor selectivity

(2015) Carmina Micelli et al.   DRUG DISCOVERY TODAY

Design, synthesis and antiproliferative activities of novel benzamides derivatives as HDAC inhibitors

(2015) Yanyang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells

(2015) Yi-Min Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Emerging approaches for histone deacetylase inhibitor drug discovery

(2015) Clemens Zwergel et al.   Expert Opinion on Drug Discovery

In-silicoanalysis of Sirt2 fromSchistosoma mansoni: structures, conformations, and interactions with inhibitors

(2015) Raghvendra Singh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Thiol versus hydroxamate as zinc binding group in HDAC inhibition: AnAb initioQM/MM molecular dynamics study

(2015) Wenjing Gong et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities

(2015) Yiwu Yao et al.   JOURNAL OF MEDICINAL CHEMISTRY

HC toxin (a HDAC inhibitor) enhances IRS1–Akt signalling and metabolism in mouse myotubes

(2015) Hayden Weng Siong Tan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors

(2015) Jelena Melesina et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition

(2015) Jagannath Behera et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Molecular docking and molecular dynamics study on SmHDAC1 to identify potential lead compounds against Schistosomiasis

(2015) Raghvendra Singh et al.   MOLECULAR BIOLOGY REPORTS

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

(2015) Madhusoodanan Mottamal et al.   MOLECULES

Histone deacetylases as therapeutic targets — From cancer to cardiac disease

(2015) Alon Abend et al.   PHARMACOLOGY & THERAPEUTICS

Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays

(2015) Zainab Noor et al.   PLoS One

In vitro cytotoxicity evaluation of HDAC inhibitor Apicidin in pancreatic carcinoma cells subsequent time and dose dependent treatment

(2015) Monika Bauden et al.   TOXICOLOGY LETTERS

Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group

(2015) Youxuan Li et al.   MedChemComm

Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor

(2015) Loredana Vesci et al.   Oncotarget

Exploring the Potential binding Sites of Some Known HDAC Inhibitors on Some HDAC8 Conformers by Docking Studies

(2014) Yudibeth Sixto-López et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase Inhibitor on HDAC4 and K562 Leukemia Cell

(2014) Xiao-Hui Li et al.   Asian Pacific Journal of Cancer Prevention

Bicyclic tetrapeptides as potent HDAC inhibitors: Effect of aliphatic loop position and hydrophobicity on inhibitory activity

(2014) Md. Nurul Islam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RETRACTED: Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors

(2014) Md. Ashraful Hoque et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents

(2014) Jianjun Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform

(2014) Christopher Blackburn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of class I HDAC isoform selectivity of largazole analogues

(2014) Bumki Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bicyclic tetrapeptide histone deacetylase inhibitors with methoxymethyl ketone and boronic acid zinc-binding groups

(2014) Md. Nurul Islam et al.   BIOORGANIC CHEMISTRY

Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

(2014) Agnieszka Szyk et al.   CELL

Selective class IIa HDAC inhibitors: myth or reality

(2014) Eros Di Giorgio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase I First-in-Human Study of CUDC-101, a Multitargeted Inhibitor of HDACs, EGFR, and HER2 in Patients with Advanced Solid Tumors

(2014) T. Shimizu et al.   CLINICAL CANCER RESEARCH

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

(2014) Samir Mehndiratta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity

(2014) Yurie Fukui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors

(2014) Yiwu Yao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Energy-optimised pharmacophore approach to identify potential hotspots during inhibition of Class II HDAC isoforms

(2014) Shabir Ahmad Ganai et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

(2014) Srinivasaraghavan Kannan et al.   Journal of Chemical Information and Modeling

ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors

(2014) Giuseppe Giannini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chidamide, a histone deacetylase inhibitor, functions as a tumor inhibitor by modulating the ratio of Bax/Bcl-2 and P21 in pancreatic cancer

(2014) BIN ZHAO et al.   ONCOLOGY REPORTS

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

Histone deacetylases in memory and cognition

(2014) J. Penney et al.   Science Signaling

Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors

(2013) Chengqing Ning et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

(2013) Tong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry

(2013) Qiao Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors

(2013) Maurizio Taddei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC

(2013) Sridurga Mithraprabhu et al.   BRITISH JOURNAL OF HAEMATOLOGY

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

(2013) Hsueh-Yun Lee et al.   CHEMBIOCHEM

Peptide Based Macrocycles: Selective Histone Deacetylase Inhibitors with Antiproliferative Activity

(2013) H. Rajak et al.   CURRENT MEDICINAL CHEMISTRY

Histone Methyltransferase Inhibitors: Novel Epigenetic Agents for Cancer Treatment

(2013) C. Zagni et al.   CURRENT MEDICINAL CHEMISTRY

Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2013) Nguyen-Hai Nam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent Histone Deacetylase Inhibitors Derived from 4-(Aminomethyl)-N-hydroxybenzamide with High Selectivity for the HDAC6 Isoform

(2013) Christopher Blackburn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif

(2013) Florence F. Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Chimeric c-Src Kinase and HDAC Inhibitor

(2013) Kristin S. Ko et al.   ACS Medicinal Chemistry Letters

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

(2013) Martin Marek et al.   PLoS Pathogens

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

(2012) Ke Gong et al.   BIOCHEMICAL JOURNAL

Development and therapeutic impact of HDAC6-selective inhibitors

(2012) Sabrina Dallavalle et al.   BIOCHEMICAL PHARMACOLOGY

Energy based pharmacophore mapping of HDAC inhibitors against class I HDAC enzymes

(2012) Subha Kalyaanamoorthy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II

(2012) Chulho Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors

(2012) Yanyang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

(2012) Diana A. Stolfa et al.   ChemMedChem

Spiro[chromane-2,4′-piperidine]-Based Histone Deacetylase Inhibitors with Improved in vivo Activity

(2012) Florian Thaler et al.   ChemMedChem

Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling

(2012) C. Qian et al.   CLINICAL CANCER RESEARCH

Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

(2012) Giuseppe Giannini et al.   Future Medicinal Chemistry

Modulation of Histone Deacetylase 6 (HDAC6) Nuclear Import and Tubulin Deacetylase Activity through Acetylation

(2012) Yuanjing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction

(2012) Laura Silvestri et al.   Journal of Chemical Information and Modeling

Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations

(2012) Subha Kalyaanamoorthy et al.   Journal of Chemical Information and Modeling

Synthesis and Biological Evaluation of 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indoles as Potent Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

(2012) Mei-Jung Lai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

(2012) Joel A. Bergman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, evaluation and molecular modeling of cyclic tetrapeptide histone deacetylase inhibitors as anticancer agents

(2012) Dawei Huang et al.   JOURNAL OF PEPTIDE SCIENCE

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo

(2012) Han-Lin Huang et al.   PLoS One

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

(2012) Cheng Wang et al.   MedChemComm

Biological Evaluation of New Largazole Analogues: Alteration of Macrocyclic Scaffold with Click Chemistry

(2012) Xianlin Li et al.   ACS Medicinal Chemistry Letters

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors

(2011) Michael Shultz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors

(2011) Cristina Rossi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

(2011) Cristina Rossi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2011) Dao Thi Kim Oanh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chatting histone modifications in mammals

(2011) A. Izzo et al.   Briefings in Functional Genomics

Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours

(2011) A R A Razak et al.   BRITISH JOURNAL OF CANCER

Structure-based optimization of click-based histone deacetylase inhibitors

(2011) Jingli Hou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

(2011) Haishan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Tetrahydroisoquinoline-Based Hydroxamic Acid Derivative (ZYJ-34c) as Histone Deacetylase Inhibitor with Potent Oral Antitumor Activities

(2011) Yingjie Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Second-Generation Histone Deacetylase 6 Inhibitors Enhance the Immunosuppressive Effects of Foxp3+ T-Regulatory Cells

(2011) Jay H. Kalin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities

(2011) Cheng Wang et al.   JOURNAL OF NATURAL PRODUCTS

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

(2011) John Spencer et al.   ACS Medicinal Chemistry Letters

Epigenetic treatment of neurological disease

(2011) Steven G Gray   Epigenomics

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Property based optimization of δ-lactam HDAC inhibitors for metabolic stability

(2010) Hong Chul Yoon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors

(2010) Eunhyun Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

(2010) Chittari Pabba et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Macrocyclic Histone Deacetylase Inhibitors

(2010) Sandra C. Mwakwari et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin

(2010) Akiko Hayashi et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer

(2010) Xiong Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton

(2010) Sandra C. Mwakwari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy

(2010) Xudong Liao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

(2010) V. Novotny-Diermayr et al.   MOLECULAR CANCER THERAPEUTICS

Identifying Novel Type ZBGs and Nonhydroxamate HDAC Inhibitors Through a SVM Based Virtual Screening Approach

(2010) X. H. Liu et al.   Molecular Informatics

A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma

(2009) Monica Galli et al.   ANNALS OF HEMATOLOGY

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

(2009) Haishan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

(2009) Peter Atadja   CANCER LETTERS

Computational Studies on the Histone Deacetylases and the Design of Selective Histone Deacetylase Inhibitors

(2009) Difei Wang   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation

(2009) Hao Tang et al.   Journal of Chemical Information and Modeling

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

(2009) Olaf Kinzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors

(2009) Nobuaki Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition

(2009) Tracey Pirali et al.   MOLECULAR DIVERSITY

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues

(2008) K. T. Andrews et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni

(2008) Frédérik Oger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Synthesis and structure–activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group

(2008) Po C. Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

(2008) David V. Smil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors

(2008) Guillermina Estiu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

(2007) David J. Witter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of ligand features essential for HDACs inhibitors by pharmacophore modeling

(2007) Ya-dong Chen et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection

(2007) Rajiv P. Sharma et al.   SCHIZOPHRENIA RESEARCH