Article
Pharmacology & Pharmacy
Daniel Heudobler, Christian Schulz, Jurgen R. Fischer, Peter Staib, Thomas Wehler, Thomas Suedhoff, Thomas Schichtl, Jochen Wilke, Joachim Hahn, Florian Lueke, Martin Vogelhuber, Sebastian Klobuch, Tobias Pukrop, Wolfgang Herr, Swantje Held, Kristine Beckers, Gauthier Bouche, Albrecht Reichle
Summary: The biomodulatory therapy was found to be inferior to nivolumab in terms of progression-free survival, but overall survival was similar in both groups. The well-tolerated biomodulatory therapy may potentially prime tumor tissues for effective checkpoint inhibitor therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Dennis C. Harrer, Marcus Jakob, Martin Vogelhuber, Florian Lueke, Kirsten Utpatel, Selim Corbacioglu, Wolfgang Herr, Albrecht Reichle, Daniel Heudobler
Summary: Metronomic biomodulation therapy (MBT) may be an effective treatment for multi-system LCH, even in patients refractory to multiple systemic chemotherapies.
LEUKEMIA & LYMPHOMA
(2022)
Article
Oncology
Yen-Hao Chen, Chih-Chi Wang, Yen-Yang Chen, Jing-Houng Wang, Chao-Hung Hung, Yuan-Hung Kuo
Summary: This study investigated the efficacy and safety of low-dose nivolumab in the management of hepatocellular carcinoma. The results suggest that low-dose nivolumab may be an alternative option for patients with advanced HCC who cannot afford the high cost of immune checkpoint inhibitors in real-world practice.
Article
Oncology
Giovanni Brandi, Alessandro Di Federico, Alessandro Rizzo, Stefania De Lorenzo, Francesco Vasuri, Stefano Brocchi, Rita Golfieri, Maria Cristina Morelli, Giorgio Frega, Andrea Palloni
Summary: Metronomic chemotherapy is a neglected but effective treatment option for advanced hepatocellular carcinoma (HCC) patients, even among those who cannot afford standard treatments. Metronomic capecitabine has shown good tolerability and efficacy in the treatment of advanced HCC.
Article
Oncology
Hiroyuki Suzuki, Hideki Iwamoto, Masahito Nakano, Toru Nakamura, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Dan Nakano, Ryoko Kuromatsu, Takashi Niizeki, Shusuke Okamura, Shigeo Shimose, Tomotake Shirono, Yu Noda, Naoki Kamachi, Hirohisa Yano, Atsushi Kawaguchi, Hironori Koga, Takuji Torimura
Summary: The combination of sorafenib with S-1 metronomic chemotherapy showed potential efficacy in treating advanced HCC with tolerable adverse events. Although the objective response rate was higher than sorafenib monotherapy, there were no significant differences in overall survival or time to progression. Adverse events were more common in the combination therapy group, but no patients had to discontinue treatment due to severe adverse events.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Chih-Wen Twu, Po-Ju Lin, Hsiao-Hui Tsou, Yi-Chun Liu, Rong-San Jiang, Kai-Li Liang, Tian-Yun Lin, Wen-Yi Wang, Jin-Ching Lin
Summary: This study investigated the survival impact and toxicity of maintenance metronomic chemotherapy in patients with metastatic/recurrent nasopharyngeal carcinoma. The results showed that maintenance chemotherapy significantly improved overall and progression-free survivals while demonstrating low toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Zongyi Yin, Dongying Chen, Shuang Liang, Xiaowu Li
Summary: Hepatocellular carcinoma (HCC) is characterized by low resection and high postoperative recurrence rates. Neoadjuvant therapy (NAT) is widely employed in the routine management of several solid tumors, but its effects on HCC remain inconclusive. With the development of targeted therapy and immunotherapy, NAT for HCC may become imminent, and future research should focus on identifying biomarkers for treatment response, exploring mechanisms of resistance, and standardizing the endpoints of NAT.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Engineering, Biomedical
Seho Kweon, Yoo-Seong Jeong, Seung Woo Chung, Hanul Lee, Ha Kyeong Lee, Seong Jin Park, Jeong Uk Choi, Jooho Park, Suk-Jae Chung, Youngro Byun
Summary: This study aims to identify the optimal metronomic chemotherapy (MCT) regimen of doxorubicin (DOX) by determining the concentration-response relationships of tumor suppression and cardiac toxicity. By utilizing an oral DOX formulation complexed with deoxycholic acid, a physiologically-based pharmacokinetic model was linked to toxicodynamic and pharmacodynamic models to generate drug profiles. The established mathematical model facilitates the calculation of adequate in vivo-relevant dosages and intervals, providing a useful guideline for the design and evaluation of oral DOX formulations.
Review
Biochemistry & Molecular Biology
Ching-Tso Chen, Tsung-Hao Liu, Yu-Yun Shao, Kao-Lang Liu, Po-Chin Liang, Zhong-Zhe Lin
Summary: Hepatic artery infusion chemotherapy (HAIC) is a well-established treatment for advanced hepatocellular carcinoma (HCC) in East Asia, but lacks international recognition. Evidence supporting its overall survival benefits compared to standard treatments is insufficient. Future research needs to standardize key factors to reveal the clinical value of HAIC-based treatments for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Longjiang She, Kun Tian, Jiaqi Han, Weihan Zuo, Zhu Wang, Ning Zhang
Summary: Adding metronomic capecitabine to concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma patients has been shown to be a cost-effective strategy, resulting in additional quality-adjusted life years and a favorable incremental cost-effective ratio at a willingness-to-pay threshold of $33,585 per QALY.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yi-Hsuan Lai, Kai-Che Tung, San-Chi Chen
Summary: Actionable gene has not been discovered in HCC, but DDR gene mutation in HCC may have potential therapeutic implications for PARP inhibitors.
Article
Oncology
Hung Ho-Xuan, Gerhard Lehmann, Petar Glazar, Foivos Gypas, Norbert Eichner, Kevin Heizler, Hans J. Schlitt, Mihaela Zavolan, Nikolaus Rajewsky, Gunter Meister, Christina Hackl
Summary: Colorectal cancer is a common cancer type with a high mortality rate, and chemotherapy often leads to chemo-resistance and tumor relapse. Low dose metronomic (LDM) therapy is a novel chemotherapeutic approach that may offer new potential therapeutic targets.
Review
Oncology
Xin Jin, Kangjun Zhang, Taishi Fang, Xinchen Zeng, Xu Yan, Jianxin Tang, Ziming Liang, Linjie Xie, Dong Zhao
Summary: This article reports a case of successful treatment of HCC recurrence after liver transplantation using immune checkpoint inhibitor therapy. The combination of low-dose nivolumab and lenvatinib showed positive results in preventing HCC recurrence, despite limited data on the safety of PD-1 inhibitors after liver transplantation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ji Hyung Hong, In Sook Woo
Summary: The use of immune checkpoint inhibitors (ICIs) in clinical practice for the treatment of metastatic colorectal cancer (mCRC) is currently limited to a small subset of patients. Combining ICIs with anti-angiogenic inhibitors has shown promising efficacy in early phase trials. Additionally, low-dose metronomic (LDM) chemotherapy has potential as a combination partner with ICIs for immunologically cold mCRC tumors.
Article
Biochemistry & Molecular Biology
Minsik Park, Joohwan Kim, Taesam Kim, Suji Kim, Wonjin Park, Kwon-Soo Ha, Sung Hwan Cho, Moo-Ho Won, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Summary: The study revealed that low-dose doxorubicin can inhibit tumor growth and metastasis by inducing REDD1 expression to impair the function of tumor-associated endothelial cells. REDD1 was found to suppress the transcription of vascular endothelial growth factor receptor by inhibiting mTORC1-dependent translation, thus inhibiting tumor angiogenesis and lymphangiogenesis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)