期刊
MEDICAL MYCOLOGY
卷 56, 期 7, 页码 911-915出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myx126
关键词
Paracoccidioides brasiliensis; dendritic cells; TLR9; fungicidal activity; H2O2
Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which themicroorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H2O2 levels.
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