Simulations of CYP51A from Aspergillus fumigatus in a model bilayer provide insights into triazole drug resistance

First itraconazole resistant Aspergillus fumigatus clinical isolate harbouring a G54E substitution in Cyp51Ap in South America

(2017) Florencia Leonardelli et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

cyp51A-based mechanism of azole resistance inAspergillus fumigatus: Illustration by a new 3D Structural Model ofAspergillus fumigatusCYP51A protein

(2016) Musang Liu et al.   MEDICAL MYCOLOGY

Epidemiology and molecular mechanisms of antifungal resistance in CandidaandAspergillus

(2016) Sarah Santos Gonçalves et al.   MYCOSES

Clinical implications of globally emerging azole resistance inAspergillus fumigatus

(2016) Jacques F. Meis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multiplecyp51A-Based Mechanisms Identified in Azole-Resistant Isolates of Aspergillus fumigatus from China

(2015) Musang Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nationwide Surveillance of Azole Resistance in Aspergillus Diseases

(2015) Edith Vermeulen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs

(2015) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

(2015) Nathan P. Wiederhold et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Development and Application of a Nonbonded Cu2+ Model That Includes the Jahn–Teller Effect

(2015) Qinghua Liao et al.   Journal of Physical Chemistry Letters

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms

(2014) Anuradha Chowdhary et al.   Future Microbiology

Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania

(2014) A. Chowdhary et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Force Field Independent Metal Parameters Using a Nonbonded Dummy Model

(2014) Fernanda Duarte et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

(2014) B. C. Monk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azole resistance in Aspergillus fumigatus

(2013) Edith Vermeulen et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Environmental study of azole-resistantAspergillus fumigatuswith TR34/L98H mutations in thecyp51A gene in Iran

(2013) Hamid Badali et al.   MYCOSES

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

(2013) Anuradha Chowdhary et al.   PLoS Pathogens

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance

(2013) Laura Alcazar-Fuoli et al.   Frontiers in Microbiology

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

(2012) Arnau Cordomí et al.   Journal of Chemical Theory and Computation

The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

(2011) Eveline Snelders et al.   FUNGAL GENETICS AND BIOLOGY

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction

(2011) Laura Alcazar-Fuoli et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India

(2011) A. Chowdhary et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle

(2011) Kiumars Shahrokh et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

(2009) J. A. Lundbaek et al.   Journal of the Royal Society Interface

Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America

(2008) Thomas J. Walsh et al.   CLINICAL INFECTIOUS DISEASES