Review
Cell Biology
Thamil Selvee Ramasamy, Yong Mei Yee, Ilyas M. Khan
Summary: Osteoarthritis is a common degenerative joint disease associated with aging, where damage to articular chondrocytes plays a key role. Understanding the complexity of cellular aging is crucial for developing new therapies targeting the specific causes of age-related functional decline in OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Jongyun Kim, Arunkumar Shanmugasundaram, Cheong Bin Lee, Jae Rim Kim, Jeong Jae Park, Eung-Sam Kim, Bong-Kee Lee, Dong-Weon Lee
Summary: This study proposes a grooved polydimethylsiloxane (PDMS) membrane embedded with silver nanowires (AgNWs-E-PDMS) to enhance the maturation and contractile properties of cardiomyocytes and provide a more accurate evaluation of drug-induced cardiotoxicity.
Article
Biochemical Research Methods
Jongyun Kim, Arunkumar Shanmugasundaram, Cheong Bin Lee, Jae Rim Kim, Jeong Jae Park, Eung-Sam Kim, Bong-Kee Lee, Dong-Weon Lee
Summary: This study proposes a grooved polydimethylsiloxane (PDMS) membrane embedded with silver nanowires (AgNWs-E-PDMS) to enhance the maturation and contractile properties of cardiomyocytes. The proposed device provides a more accurate evaluation of drug-induced cardiotoxicity and demonstrates its feasibility as a drug screening platform.
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Yustina M. Puspitasari, Stefano Ministrini, Lena Schwarz, Caroline Karch, Luca Liberale, Giovanni G. Camici
Summary: The improvements in healthcare services and quality of life are leading to a longer life expectancy, resulting in a larger population of elderly individuals who are more susceptible to age-related cardiovascular diseases. Inflammation has been recognized as a key factor in the pathogenesis of cardiovascular diseases, suggesting that inflamm-aging could potentially be a driver of age-related cardiovascular afflictions and a viable therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Valeria Vincenza Alvino, Khaled Abdelsattar Kassem Mohammed, Yue Gu, Paolo Madeddu
Summary: There is increasing clinical interest in pericytes due to their crucial roles in controlling vascular function and possible therapeutic applications. However, discrepancies in defining and isolating pericytes, as well as difficulties in formulating an unequivocal definition, present challenges. Developing upgraded protocols and integrating advanced techniques may help realize the full potential of pericytes in health and regenerative medicine.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Fabio Ramos Costa, Mariana Ramos Costa Marques, Vinicius Calumby Costa, Gabriel Silva Santos, Rubens Andrade Martins, Marcia da Silva Santos, Maria Helena Andrade Santana, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Joao Vitor Bizinotto Lana, Jose Fabio Santos Duarte Lana
Summary: Musculoskeletal diseases, such as osteoarthritis and tendinopathies, have a significant impact on society and individuals' quality of life. Intra-articular hyaluronic acid (HA) has emerged as a safe and effective treatment option for these conditions, providing multiple benefits such as lubrication, anti-inflammation, and stimulation of cellular activity. This review addresses the scientific, commercial, and clinical aspects of HA, providing physicians with a deeper understanding of disease processes, tissue repair mechanisms, and the advantages of different HA types.
Article
Biotechnology & Applied Microbiology
Chantal Voskamp, Wendy J. L. M. Koevoet, Gerjo J. V. M. Van Osch, Roberto Narcisi
Summary: This study investigated the impact of senescence and the senescence-associated secretory phenotype (SASP) on chondrogenic differentiation of MSCs. Inducing senescence in cells during expansion or early differentiation significantly reduced cartilage matrix formation. However, inducing senescence at a later stage of differentiation did not significantly affect chondrogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Giacomo Bernava, Laura Iop
Summary: Due to the limited regenerative ability of cardiomyocytes, traditional treatment methods are unable to directly repair heart damage. In recent years, significant progress has been made in the field of cardiac tissue engineering, which utilizes biomimetic design and fabrication of cardiac scaffolds and patches to promote cell growth and tissue regeneration, providing a new direction for the treatment of heart diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Barbara Bellei, Federica Papaccio, Mauro Picardo
Summary: Vitiligo is a complex disorder that has a significant impact on patients' self-esteem and social life. There is no specific cure yet, and the long-term persistence of repigmentation is unpredictable. Recently, regenerative approaches involving cell-based and cell-free methods have been suggested to treat vitiligo.
Article
Computer Science, Artificial Intelligence
Ziyu Su, Thomas E. Tavolara, Gabriel Carreno-Galeano, Sang Jin Lee, Metin N. Gurcan, M. K. K. Niazi
Summary: This study proposes attention2majority, a weak multiple instance learning model, to automatically and efficiently process whole slide images (WSIs) of stained tissue sections for classification. By using intelligent sampling and a multi-head attention-based multiple instance learning model, slide-level classification based on high-confidence patches is achieved.
MEDICAL IMAGE ANALYSIS
(2022)
Review
Cell & Tissue Engineering
Daniela P. Vasconcelos, Artur P. Aguas, Judite N. Barbosa
Summary: Inflammasomes are intracellular structures that play a crucial role in innate immune responses as key players in host defense. They are assembled upon the perception of pathogens or danger signals and activate the production of pro-inflammatory cytokines. The inflammasome is involved in various inflammatory processes and tissue repair, making it a potential target for regenerative medicine.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Biomedical
Hao Yang, Liu Song, Bingxue Sun, Di Chu, Leilei Yang, Meng Li, Huan Li, Yun Dai, Zhuo Yu, Jianfeng Guo
Summary: The study confirmed the potential of paeoniflorin (PF) for transitioning macrophages and developed a high molecular weight hyaluronic acid (HA) hydrogel that significantly promoted cutaneous healing in experimental diabetic mice, showing promising clinical translation potential.
MATERIALS TODAY BIO
(2021)
Review
Endocrinology & Metabolism
Molly Monsour, Cesar Borlongan
Summary: Stroke pathology and treatments usually focus on the brain, but inflammation in peripheral organs also plays a significant role. This review discusses the robust inflammatory response in peripheral organs to stroke and innovative stroke therapies that target peripheral inflammation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Gian Luca Ragazzoni, Luna Cavigli, Elena Cavarretta, Silvia Maffei, Giulia Elena Mandoli, Concetta Pastore, Serafina Valente, Marta Focardi, Matteo Cameli, Giovanni Di Salvo, Guido Pieles, Flavio D'Ascenzi
Summary: This article discusses the importance of interpreting resting ECG and cardiac imaging in paediatric athletes and provides a practical guide for clinicians. It highlights the need for early detection of life-threatening conditions while also considering the risk of overdiagnosis and unwarranted disqualification from sports practice.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Alessandra D'Amico, Chiara Fossati, Fabio Pigozzi, Paolo Borrione, Mariangela Peruzzi, Simona Bartimoccia, Filippo Saba, Annachiara Pingitore, Giuseppe Biondi-Zoccai, Luigi Petramala, Fabrizio De Grandis, Daniele Vecchio, Luca D'Ambrosio, Sonia Schiavon, Luigi Sciarra, Cristina Nocella, Elena Cavarretta
Summary: This study aimed to investigate the effects of a mixture containing three compounds on muscle injury biomarkers in endurance athletes. The results showed that the intake of this mixture significantly reduced oxidative stress and positively modulated autophagy, resulting in a significant decrease in muscle injury biomarkers.
Review
Sport Sciences
Agostino Rossoni, Marco Vecchiato, Erica Brugin, Eliana Tranchita, Paolo Emilio Adami, Manuela Bartesaghi, Elena Cavarretta, Stefano Palermi
Summary: Recently, eSports has emerged as a popular form of new media, thanks to the widespread availability of games and online technologies. Despite ongoing discussions about its definition, eSports athletes undergo rigorous training, compete in tournaments, and must follow rules set by governing bodies, just like traditional athletes. However, like any competitive discipline, eSports players are susceptible to injuries related to their sedentary lifestyle, improper posture, prolonged screen time, and repetitive movements. This paper highlights the importance of conducting pre-participation evaluations and implementing effective injury prevention strategies for professional eSports athletes.
Review
Cardiac & Cardiovascular Systems
Annachiara Pingitore, Mariangela Peruzzi, Sofia Calaciura Clarich, Zefferino Palama, Luigi Sciarra, Elena Cavarretta
Summary: Athletes undergo regular sports medicine examinations and electrocardiography to screen for arrhythmias, although these methods may not always be successful in identifying rhythm disturbances. However, there is a lack of research on the frequency of cardiac symptoms and the use of cardiac monitoring specifically in athletes. This review aims to provide physicians in the field of sports cardiology with various options for heart rhythm monitoring in order to tailor the diagnostic process and improve diagnostic accuracy when an arrhythmia is suspected in an athlete.
CLINICAL CARDIOLOGY
(2023)
Review
Health Care Sciences & Services
Francesco Perone, Annachiara Pingitore, Edoardo Conte, Geza Halasz, Marco Ambrosetti, Mariangela Peruzzi, Elena Cavarretta
Summary: Obesity is associated with an increased risk of cardiovascular disease events and mortality, as well as other complications such as pre-type 2 diabetes and non-alcoholic fatty liver diseases. While physical activity and diet are important in reducing cardiovascular risk, they are not always successful strategies. Pharmacological treatments and bariatric surgery show promise in improving cardiovascular outcomes, but safety issues and cost restrict their use. Cardiac rehabilitation programs have been shown to improve cardiovascular disease risk factors, quality of life, and exercise capacity in obese patients. A multidisciplinary approach is needed to effectively reduce cardiovascular disease risk and mortality.
Review
Cardiac & Cardiovascular Systems
Mattia Petrungaro, Liuba Fusco, Elena Cavarretta, Antonio Scara, Alessio Borrelli, Silvio Romano, Renata Petroni, Flavio D'Ascenzi, Luigi Sciarra
Summary: Atrial fibrillation (AF) is a common sustained arrhythmia with high morbidity, disability, and mortality. Physical activity has been shown to reduce the risk of cardiovascular disease and all-cause mortality, and it may also reduce the risk of AF while improving overall well-being. However, intense physical activity has been associated with an increased risk of AF.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Mariangela Peruzzi, Karin Covi, Matteo Saccucci, Annachiara Pingitore, Wael Saade, Luigi Sciarra, Maria P. Cristalli, Fabio Miraldi, Giacomo Frati, Elena Cavarretta
Summary: Periodontal disease (PD) and cardiovascular diseases (CVD) have been extensively studied and are among the most common pathologies in the world. This umbrella review aimed to evaluate the association between these two conditions. A comprehensive literature search was conducted, and 31 systematic reviews and 8 meta-analyses were included. The results suggested that PD is associated with a higher risk of developing CVD and cerebrovascular diseases, but further research is needed to investigate the potential effects of periodontitis treatment on CVD events.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Tona, Marta Vadori, Giovanni Civieri, Giulia Masiero, Laura Iop, Giorgia Antonelli, Martina Perazzolo Marra, Federica Bianco, Annagrazia Cecere, Giulia Lorenzoni, Natalia Naumova, Giacomo Bernava, Daniela Basso, Mario Plebani, Emanuele Cozzi, Sabino Iliceto
Summary: This study aimed to investigate the relationship between autoantibodies activating endothelin-1 receptor type A (ETAR-AAs) and no-reflow (NR) after primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI). The study found that ETAR-AAs seropositivity was associated with NR in STEMI patients, suggesting potential new options for the management of myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Henner Hanssen, Trine Moholdt, Martin Bahls, Alessandro Biffi, Monika Siegrist, Adam J. Lewandowski, Giuseppe Biondi-Zoccai, Elena Cavarretta, Ane Kokkvoll, Maja-Lisa Lochen, Viviana Maestrini, Rita Salvador Pinto, Stefano Palermi, David Thivel, Malgorzata Wojcik, Dominique Hansen, Emeline M. Van Craenenbroeck, Daniel Weghuber, Nicolle Kraenkel, Monica Tiberi
Summary: There is an urgent need to optimize cardiovascular risk management and primary prevention of childhood obesity to combat the health threat and socioeconomic burden of cardiovascular disease. Lifestyle interventions have high potential to change disease trajectories by optimizing screening programs and risk management strategies for obesity-related cardiovascular risks.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Giacomo Bernava, Laura Iop
Summary: Due to the limited regenerative ability of cardiomyocytes, traditional treatment methods are unable to directly repair heart damage. In recent years, significant progress has been made in the field of cardiac tissue engineering, which utilizes biomimetic design and fabrication of cardiac scaffolds and patches to promote cell growth and tissue regeneration, providing a new direction for the treatment of heart diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Civieri, Marta Vadori, Giulia Masiero, Laura Iop, Donatella Tansella, Valeria Pergola, Emanuele Cozzi, Sabino Iliceto, Francesco Tona
Summary: This study found that the seropositivity of autoantibodies targeting angiotensin-II receptor type 1 and endothelin-1 receptor type A is significantly higher in SCAD women with myocardial infarction compared to healthy women and female patients with STEMI. This suggests a possible role for AT1R-AAs and ETAR-AAs in the pathophysiology of SCAD in women with acute myocardial infarction and further studies are warranted.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Zefferino Palama, Antonio Gianluca Robles, Matteo Paoletti, Martina Nesti, Ermenegildo De Ruvo, Antonio Scara, Alessio Borrelli, Gabriele De Masi De Luca, Mariano Rillo, Leonardo Calo, Elena Cavarretta, Silvio Romano, Luigi Sciarra
Summary: The study assessed the inducibility of supraventricular tachycardia (SVT) in patients referred for atrial fibrillation (AF) ablation and the effects of SVT ablation on AF recurrences. It found that 19% of patients had inducible SVT, and SVT ablation had a preventive effect on AF recurrences.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Francesco Perone, Mariangela Peruzzi, Edoardo Conte, Luigi Sciarra, Giacomo Frati, Elena Cavarretta, Annachiara Pingitore
Summary: The incidence of heart valve disease (HVD) has been increasing due to an aging population, with mitral valve (MV) disease being the second most common type of HVD. Regular physical activity has been proven to reduce mortality rates, but the hemodynamic changes during exercise may worsen the progression of MV disease and potentially trigger major cardiac events. It is important to define criteria for exercise prescription and competitive sport participation in young patients with HVD, balancing the benefits and risks. This review provides an overview of MV disease and encourages physicians to incorporate exercise in their practice when appropriate.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Nutrition & Dietetics
Rosita Stanzione, Maurizio Forte, Maria Cotugno, Francesca Oppedisano, Cristina Carresi, Simona Marchitti, Vincenzo Mollace, Massimo Volpe, Speranza Rubattu
Summary: High salt load is damaging to vascular cells and a risk factor for cardiovascular diseases. In this study, we tested the effects of a bergamot polyphenolic fraction (BPF) on high-salt-induced injury in cerebral endothelial cells. BPF reduced oxidative stress, improved cell viability and angiogenesis, and decreased mitochondrial oxidative stress. BPF may be a valuable adjunct for treating vascular disorders.
