期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 112, 期 -, 页码 169-176出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2014.11.004
关键词
Bioaccumulation; 17 beta-estradiol; 17 alpha-ethynylestradiol; Long-term exposure; Crucian carp
资金
- National Natural Science Foundation of China [21267012, 41401558]
- Application Fundamental Key Basic Research Foundation of Yunnan Province, China [2013FA011]
- China Postdoctoral Science Foundation [2013M531987, 2014T70887]
- Application Fundamental Research Foundation of Yunnan Province, China [2012FB124]
Bioaccumulation and effects of 17 beta-estradiol (E2) and 17 alpha-ethynylestradiol (EE2) were assessed by crucian carp (Carassius auratus) following single and binary mixture exposures in flow-through exposure system for 16 months. In comparison with water control (DWC) and solvent control (SC), a significant reduction in body weight, body length and gonadosomatic index (GSI), and increase in hepatosomatic index (HSI) and plasma vitellogenin (VTG) levels were observed, in a time- and concentration-dependent manner. Bioconcentration factors (BCFs) of E2 and EE2 in fish muscle ranged from 3.2 to 40 and from 64 to 123, respectively. Crucian carp were found to be more sensitive to EE2 than E2. The bioaccumulation and toxicological effects in binary mixture exposed fish (mixture of E2 and EE2) were more significant than exposure of individual compound. Crucian carp is sensitive to E2 and EE2 in long-term laboratory exposure experiments and can be used as a potential model species for investigating the toxicity of hormones. (C) 2014 Elsevier Inc. All rights reserved.
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