期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 161, 期 -, 页码 181-197出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.09.003
关键词
Neurodegenerative disease; Mitochondria; Metabolism; Electron transport chain; Huntington's disease
资金
- National Institutes of Health [NS060115, CA092584]
Mitochondrial dysfunction and ensuing oxidative damage is typically thought to be a primary cause of Huntington's disease, Alzheimer's disease, and Parkinson disease. There is little doubt that mitochondria (MT) become defective as neurons die, yet whether MT defects are the primary cause or a detrimental consequence of toxicity remains unanswered. Oxygen consumption rate (OCR) and glycolysis provide sensitive and informative measures of the functional status MT and the cells metabolic regulation, yet these measures differ depending on the sample source; species, tissue type, age at measurement, and whether MT are measured in purified form or in a cell. The effects of these various parameters are difficult to quantify and not fully understood, but clearly have an impact on interpreting the bioenergetics of MT or their failure in disease states. A major goal of the review is to discuss issues and coalesce detailed information into a reference table to help in assessing mitochondrial dysfunction as a cause or consequence of Huntington's disease. Published by Elsevier Ireland Ltd.
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