期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 161, 期 -, 页码 262-269出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.03.009
关键词
Yeast; Microfluidics; Microscopy; Replicative aging; Microdissection; Lifespan
资金
- UW Nathan Shock Center of Excellence in the Basic Biology of Aging (NIH) [P30AG013280]
- NIH Training Grant [T32AG000057]
- Department of Defense, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship [32CFR 168a]
- [FA9550-11-C-0028]
The budding yeast Saccharomyces cerevisiae has been used as a model organism for the study of aging for over 50 years. In this time, the canonical aging experiment replicative lifespan analysis by manual microdissection has remained essentially unchanged. Recently, microfluidic technologies have been developed that may be able to substitute for this time- and labor-intensive procedure. These technologies also allow cell physiology to be observed throughout the entire lifetime. Here, we review these devices, novel observations they have made possible, and some of the current system limitations. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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