期刊
MATRIX BIOLOGY
卷 60-61, 期 -, 页码 38-56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2016.12.001
关键词
Versican; Hyaluronan; Glycocayix; Extracellular matrix; Leukocytes; Development; Remodeling
资金
- National Institutes of Health [P01 HL098067, U01 A1101984, R01 EB012558, U01 A1101990]
- Helmsley Charitable Trust nPOD (Network for Pancreatic Organ Donors) Award for Team Science
Hyaluronan and versican are extracellular matrix (ECM) components that are enriched in the provisional matrices that form during the early stages of development and disease. These two molecules interact to create pericellular coats and open space that facilitate cell sorting, proliferation, migration, and survival. Such complexes also impact the recruitment of leukocytes during development and in the early stages of disease. Once thought to be inert components of the ECM that help hold cells together, it is now quite clear that they play important roles in controlling cell phenotype, shaping tissue response to injury and maintaining tissue homeostasis. Conversion of hyaluronan-/versican-enriched provisional matrix to collagen-rich matrix is a hallmark of tissue fibrosis. Targeting the hyaluronan and versican content of provisional matrices in a variety of diseases including, cardiovascular disease and cancer, is becoming an attractive strategy for intervention. (C) 2016 Elsevier B.V. All rights reserved.
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