Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Nursing
Liubov Abolyan, Laura N. Haiek, Irina M. Pastbina, Ragnhild Maastrup
Summary: The study found that Russian neonatal wards generally scored high in supporting breastfeeding, especially in areas such as respect for mothers, continuity of care, having a breastfeeding policy, and rooming-in. However, they scored lower in areas such as family-centered care, antenatal informing, skin-to-skin contact, and human milk use. Most respondents expressed a desire to obtain Neo-BFHI designation in their neonatal wards.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Nursing
Katherine R. Standish, Ginny Combs, Marcy Mcmahon, Cheryl Slater, Lisa Zani, Christina Pindar, Karol Serafin, Margaret G. Parker, Barbara L. Philipp
Summary: Late preterm infants have lower breastfeeding rates and there are few interventions or guidelines for managing them in non-intensive nursery settings. This study developed and implemented an interdisciplinary breastfeeding support program, which increased nurses' attentiveness and confidence in caring for late preterm infants. However, well-designed clinical studies are needed to identify effective breastfeeding support practices.
JOURNAL OF HUMAN LACTATION
(2023)
Review
Pediatrics
Ragnhild Maastrup, Leena Hannula, Mette Ness Hansen, Aino Ezeonodo, Laura N. Haiek
Summary: The Neo-BFHI is an extension of the WHO/UNICEF Ten Steps to Successful Breastfeeding, tailored to meet the needs of infants and families in all levels of neonatal care. It includes Three Guiding Principles and Ten Steps to support breastfeeding, along with adherence to the International Code of Marketing of Breast-milk Substitutes. In 2020, WHO/UNICEF published recommendations for breastfeeding small, sick and preterm newborns in line with the Neo-BFHI.
Article
Nursing
Mariana Gonzalez de Oliveira, Desiree de Freitas Valle Volkmer
Summary: The study found that in the NICU unit under study, the majority of very low birth weight infants were breastfed at discharge. Breastfeeding at discharge was associated with shorter lengths of stay.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Multidisciplinary Sciences
Avinash S. Patil, Chad A. Grotegut, Nilesh W. Gaikwad, Shelley D. Dowden, David M. Haas
Summary: Plasma levels of DOC and 16 alpha-OHP in early gestation, combined with patient demographic and clinical data, can predict significant neonatal morbidity, neonatal length of stay, and the risk for very preterm delivery. Validation studies are needed to confirm these findings. Early identification of pregnancies at risk for preterm delivery and neonatal morbidity can lead to timely multidisciplinary care and improved perinatal outcomes.
Article
Obstetrics & Gynecology
Diane Korb, Francois Goffinet, Loic Sentilhes, Gilles Kayem, Marie Victoire Senat, Elie Azria, Thomas Schmitz
Summary: This study assessed the survival of very preterm twins to discharge without severe neonatal morbidity based on the planned mode of delivery. The results showed that planned cesarean delivery was not associated with higher survival rates compared to planned vaginal delivery. This suggests that very preterm delivery should not automatically be an indication for planned cesarean in twin pregnancies.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Adrien Flahault, Gabriel Altit, Aurelie Sonea, Anne-Sophie Gervais, Muhammad Oneeb Rehman Mian, Rong Wu, Eva Desbrousses, Ly Mai, Anik Cloutier, Jessica Simoneau, Anie Lapointe, Andreanne Villeneuve, Patrick Garceau, Michel White, Jean-Luc Bigras, Thuy Mai Luu, Anne Monique Nuyt
Summary: The study found alterations in LV dimensions and function in adults born preterm, even after adjusting for factors like body surface area. The use of antenatal steroids may lead to further reduced cardiac output in preterm individuals, indicating an increased risk of cardiovascular disease in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nursing
Leslie A. Parker, Sandra Sullivan, Nicole Cacho, Clara Engelmann, Charlene Krueger, Martina Mueller
Summary: The study compared three indicators for secretory activation in mothers of very low birth weight infants and found no correlation in the time to secretory activation between indicators. Earlier volume attainment was associated with increased milk production, and frequent expression in the first 5 days postpartum may promote earlier secretory activation.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Nutrition & Dietetics
Jing Huang, Zhi Zheng, Xiao-yan Zhao, Li-han Huang, Lian Wang, Xiao-lan Zhang, Xin-zhu Lin
Summary: Feeding preterm infants with fresh mother's own milk (MOM) can protect them from complications and improve their outcomes. Compared to pasteurized MOM, feeding fresh MOM leads to a higher survival rate, lower incidence of bronchopulmonary dysplasia, and better feeding and growth outcomes.
MATERNAL AND CHILD NUTRITION
(2023)
Article
Medicine, General & Internal
Noha Gomaa, Chaini Konwar, Nicole Gladish, Stephanie H. Au-Young, Ting Guo, Min Sheng, Sarah M. Merrill, Edmond Kelly, Vann Chau, Helen M. Branson, Linh G. Ly, Emma G. Duerden, Ruth E. Grunau, Michael S. Kobor, Steven P. Miller
Summary: This cohort study of very preterm neonates suggests that biological aging may be associated with impaired brain growth and neurodevelopmental outcomes. The associations between epigenetic aging and adverse neonatal brain health warrant further attention.
Article
Food Science & Technology
Lingyu Fang, Meili Zhang, Lianqiang Wu, Ruiquan Wang, Bangbang Lin, Jianfeng Yao, Dongmei Chen
Summary: The study demonstrated that preterm donor milk does not impact the growth of very-low-birth-weight infants, but significantly reduces feeding intolerance, shortens hospitalization time, and provides protective effects against necrotizing enterocolitis and sepsis. This suggests that preterm donor milk may lower the rate of infection in preterm infants and is worth promoting.
FOOD & NUTRITION RESEARCH
(2021)
Article
Medicine, General & Internal
Yun Cao, Siyuan Jiang, Jianhua Sun, Mingyan Hei, Laishuan Wang, Huayan Zhang, Xiaolu Ma, Hui Wu, Xiaoying Li, Huiqing Sun, Wei Zhou, Yuan Shi, Yanchen Wang, Xinyue Gu, Tongling Yang, Yulan Lu, Lizhong Du, Chao Chen, Shoo K. Lee, Wenhao Zhou
Summary: This cohort study evaluated care practices and outcomes for very preterm infants in Chinese neonatal intensive care units. The findings suggest that survival rates and survival without major morbidity for these infants in China are lower compared to high-income countries, highlighting the need for clinical quality improvement and health services reorganization to enhance outcomes.
Article
Nursing
Andini Pramono, Julie Smith, Siobhan Bourke, Jane Desborough
Summary: This study explores the experiences of midwives in implementing the Baby-Friendly Hospital Initiative in a Baby-Friendly accredited public hospital in Australia. The results show that time as a critical resource and continuity of care are key issues for midwives in supporting breastfeeding. Despite challenges, midwives remain motivated and committed to supporting breastfeeding.
JOURNAL OF HUMAN LACTATION
(2022)
Article
Nursing
Katherine Wander, Masako Fujita, Rita Spathis, Shanita Li, Daniel Armstrong, Jane Pechera, Rachael Anyim, Morgan Manganello, Cruz Torres, Camilla Herbin, Brooke Cradin, Farrah Margolin
Summary: The study aimed to characterize immune activity in human milk via in vitro stimulation for population-based research. Patterns of cytokine responses were associated with child age and maternal autoimmune disease across mother-child dyads. This method may be useful in global health research settings with high infectious disease risk, providing important insights into maternal and child health.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Gastroenterology & Hepatology
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Veronique Lenoir, Rui F. Simoes, Jose Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jeru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip-Buus, Vlad Ratziu, Jeremie Gautheron, Cecilia M. P. Rodrigues
Summary: Ripk3 deficiency protects against mitochondrial and lipid droplet dysfunction in CDAA-fed mice and fat-loaded hepatocytes, accompanied by upregulation of antioxidant systems. Ripk3 deficiency leads to smaller and increased numbers of lipid droplets in Ripk3(-/-) hepatocytes, and upregulates LD-associated proteins PLIN1 and PLIN5. Upregulation of PLIN1 not only controls LD structure but also alleviates mitochondrial stress.
Article
Obstetrics & Gynecology
Anne Ego, Isabelle Monier, Antoine Vilotitch, Gilles Kayem, Christophe Vayssiere, Eric Verspyck, Jennifer Zeitlin
Summary: Standardised longitudinal reporting of growth monitoring information did not improve antenatal detection of infants who are small for gestational age (SGA) compared to usual care.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Mariane Sentenac, Sabrina Twilhaar, Valerie Benhammou, Andrei S. S. Morgan, Samantha Johnson, Anna Chaimani, Jennifer Zeitlin
Summary: Meta-analyses of studies on the impact of very preterm birth on cognition found a marked IQ deficit among VPT children compared to term-born peers, but with unexplained heterogeneity in effect size. An umbrella review was conducted to examine the design and methodology of primary studies, revealing that methodological heterogeneity mainly influenced the choice of cognitive test used.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Jennifer Zeitlin
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Pediatrics
Adrien Aubert, Raquel Costa, Samantha Johnson, Ulrika aden, Marina Cuttini, Corine Koopman-Esseboom, Jo Lebeer, Heili Varendi, Michael Zemlin, Veronique Pierrat, Jennifer Zeitlin, SHIPS Res grp
Summary: This study investigated the risk factors for cerebral palsy (CP) and non-CP movement difficulties (MD) in extremely preterm (EPT) infants. The results showed that CP and non-CP MD have different risk factor profiles, with non-CP MD being more associated with sociodemographic factors.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Marta Clariano, Vanda Marques, Joao Vaz, Salma Awam, Marta B. Afonso, Maria Jesus Perry, Cecilia M. P. Rodrigues
Summary: The stability, bioavailability, and pharmacokinetic profiles of monocarbonyl analogs of curcumin were evaluated in this study. The curcumin analog 1e showed promising potential as an agent against colorectal cancer, with improved stability and efficacy/safety profile.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Gastroenterology & Hepatology
Andre A. Santos, Teresa C. Delgado, Vanda Marques, Carmen Ramirez-Moncayo, Cristina Alonso, Antonio Vidal-Puig, Zoe Hall, Maria Luz Martinez-Chantar, Cecilia M. P. Rodrigues
Summary: Hepatocytes in different lobule zones show distinct gene expression profiles, metabolic features, regenerative capacity, and susceptibility to damage due to the heterogeneity in oxygen, nutrient, and hormone gradients across the radial axis of the hepatic lobule. Metabolomic approaches provide a deeper understanding of the spatial metabolic profile and intercellular heterogeneity, contributing to the study of liver disease. These approaches allow for a comprehensive characterization of liver metabolic function with high spatial resolution. The challenges in achieving metabolome coverage at the single-cell level are also discussed.
Article
Health Care Sciences & Services
Elsa Lorthe, Carolina Santos, Jose Pedro Ornelas, Julia Nadine Doetsch, Sandra C. S. Marques, Raquel Teixeira, Ana Cristina Santos, Carina Rodrigues, Goncalo Goncalves, Pedro Ferreira Sousa, Joao Correia Lopes, Artur Rocha, Henrique Barros
Summary: This study aimed to assess the feasibility of recruiting and following up an e-cohort of adults born preterm worldwide and provide estimations of participation, characteristics of participants, the acceptability of questions, and the quality of data collected. The results showed that a total of 1004 persons had registered on the platform, with 333 participants completing the baseline questionnaire and 119 participants participating in the follow-up. The participants were diverse in sociodemographic and health characteristics, and the data collected had good quality.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Medicine, Research & Experimental
Vanda Marques, Fabiola Arella, Marta B. Afonso, Andre A. Santos, Cecilia M. P. Rodrigues
Summary: The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity may trigger cancer development through several mechanisms, where metabolic deregulation of adipokines can modulate multiple oncogenic molecular pathways.
Article
Gastroenterology & Hepatology
Claudia Einer, Ditte Emilie Munk, Eok Park, Banu Akdogan, Judith Nagel, Josef Lichtmannegger, Carola Eberhagen, Tamara Rieder, Mikkel H. Vendelbo, Bernhard Michalke, Ralf Wimmer, Andreas Blutke, Annette Feuchtinger, Philip Dershwitz, Ana M. DiSpirito, Tawhidul Islam, Rui E. Castro, Byong-Keol Min, TaeWon Kim, Seoyoun Choi, Dasol Kim, Chunwon Jung, Hongjae Lee, Dongsik Park, Weonbin Im, So-Young Eun, You-Hee Cho, Jeremy D. Semrau, Cecilia M. P. Rodrigues, Simon Hohenester, Thomas Damgaard Sandahl, Alan A. DiSpirito, Hans Zischka
Summary: This study tested the efficiency and safety of bacteria-derived copper binding agents (MBs) in depleting excess copper from the livers of WD rats, and found that a copper-binding agent called ARBM101 can effectively deplete liver copper to normal levels within 8 days. They developed a new treatment approach consisting of repetitive cycles of ARBM101 applications followed by rest periods to ensure long-term survival in WD rats.
Article
Gastroenterology & Hepatology
Pedro M. Rodrigues, Marta B. Afonso, Andre L. Simao, Tawhidul Islam, Maria M. Gaspar, Colm J. O'Rourke, Monika Lewinska, Jesper B. Andersen, Enara Arretxe, Cristina Alonso, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Raul Jimenez-Aguero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Carina Prip-Buus, Jesus M. Banales, Cecilia M. P. Rodrigues, Rui E. Castro
Summary: This study evaluated the role of hsa-miRNA-21-5p in the development of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients. The expression of hsa-miRNA-21-5p was found to increase with NAFLD severity and was associated with hepatic lipotoxicity. Inhibition of hsa-miRNA-21-5p was shown to prevent the progression of NAFLD to NASH and HCC.
LIVER INTERNATIONAL
(2023)
Editorial Material
Public, Environmental & Occupational Health
Alice Hocquette, Jennifer Zeitlin
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Harald Ehrhardt, Adrien M. Aubert, Ulrika Aden, Elizabeth S. Draper, Anna Gudmundsdottir, Heili Varendi, Tom Weber, Michael Zemlin, Rolf F. Maier, Jennifer Zeitlin
Summary: This study found no association between Apgar scores and long-term outcomes in infants born extremely preterm (EPT). This may be due to high interobserver variability in Apgar scoring, poorer response to resuscitation after birth among EPT infants, and the influence of more deleterious exposures in the neonatal intensive care unit or socioeconomic factors on outcomes during the first 5 years of life.
Article
Obstetrics & Gynecology
Isabelle Monier, Nathalie Lelong, Alexandra Benachi, Jean-Marie Jouannic, Babak Khoshnood, Jennifer Zeitlin
Summary: Despite advancements in prenatal screening, there is still room for improvement in the prenatal diagnosis of congenital anomalies. The study shows a relatively high proportion of anomalies that go undetected during pregnancy, with lower postnatal detection rates for severe anomalies.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Nutrition & Dietetics
Melissa Amyx, Diane Korb, Jennifer Zeitlin, Thomas Schmitz, Camille Le Ray
Summary: The objective of this study was to describe gestational weight gain (GWG) and assess the applicability of the 2009 Institute of Medicine (IOM) guidelines in a French cohort. The study found that almost half of the women had insufficient GWG according to the IOM recommendations, with only a small percentage having excessive GWG, regardless of BMI or parity. The JUMODA-derived GWG adequacy classification was lower than the IOM recommendations, indicating that a significant proportion of French women had inadequate GWG.
MATERNAL AND CHILD NUTRITION
(2023)