Review
Biochemistry & Molecular Biology
S. Rao Sirasanagandla, Isehaq Al-Huseini, R. G. Sumesh Sofin, Srijit Das
Summary: Bisphenol A (BPA) is a commonly used industrial compound, and evidence suggests that perinatal exposure to BPA increases the risk of cardiovascular diseases. Developmental programming and epigenetic modifications of genes may play a role in this impact.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Editorial Material
Medicine, Research & Experimental
Mark Hedley Vickers
Summary: There is a clear link between alterations in the early life environment and the risk for developing cardiometabolic diseases later in life, known as developmental programming. Changes in maternal nutritional environment have been associated with adverse health outcomes in offspring and can be passed on to future generations. Animal models have provided empirical data to support the developmental origins of health and disease hypothesis and have greatly contributed to our understanding of mechanisms underlying developmental programming.
Review
Nutrition & Dietetics
Eunice Mah, Oliver Chen, DeAnn J. Liska, Jeffrey B. Blumberg
Summary: This review summarizes the safety evidence and relevant clinical findings on weight management supplements containing caffeine, green tea extract, green coffee bean extract, choline, glucomannan, and capsaicinoids. The ingredients are generally safe when taken as directed and demonstrate metabolic health benefits for overweight and obese individuals.
Article
Endocrinology & Metabolism
Susana L. Matias, Michelle Pearl, Kristen Lyall, Lisa A. Croen, Tanja V. E. Kral, Daniele Fallin, Li-Ching Lee, Chyrise B. Bradley, Laura A. Schieve, Gayle C. Windham
Summary: The study found that maternal severe obesity before pregnancy increases the risk of ASD and DD in offspring, and high gestational-age-adjusted GWG is a risk factor for ASD in male children.
Article
Nutrition & Dietetics
Hai-Tao Yu, Wen-Hui Xu, Yi-Ru Chen, Ye Ji, Yi-Wei Tang, Yue-Ting Li, Jia-Yu Gong, Yi-Fei Chen, Guo-Liang Liu, Lin Xie
Summary: Maternal pre-BMI is associated with maternal-fetal plasma fatty acid profiles, with more noticeable adverse profiles in overweight mothers before pregnancy.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Liping Huang, Yongfen Chen, Yunjia Dai, Lingli Xiao, Pu Zhao, Xiaoming Ben
Summary: Recent data suggest that abnormal maternal prepregnancy BMI and excessive gestational weight gain are associated with infant birth weight and/or length, as well as impairing neurobehavioral development, especially in the areas of language and social behavior. Additionally, excessive GWG was found to be linked with lower language ability in girls but not boys.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jun Young Hong
Summary: Early-life environmental factors can have long-lasting effects on physiological functions through altering developmental processes. Recent studies support the presence of developmental programming in mammals, including humans, which influences long-term health. Perinatal glucocorticoids have been found to have persistent effects on multiple body functions in adulthood.
MOLECULES AND CELLS
(2022)
Review
Endocrinology & Metabolism
Rosiane Aparecida Miranda, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: The article discusses the association between perinatal conditions and the risk of developing thyroid dysfunction in offspring. It highlights the impact of factors such as nutrition, hormones, and environmental contaminants on the normal maturation of the thyroid gland.
Review
Nutrition & Dietetics
Amanda Renae Purcell, Sarah Jean Glastras
Summary: The global rise in obesity among women of reproductive age raises concerns about the health of their offspring. There is a strong connection between an obesogenic maternal environment and metabolic dysfunction in the offspring. Research efforts need to focus on alleviating the intergenerational onset of obesity and metabolic dysfunction.
Review
Nutrition & Dietetics
Junxiang Miao, Yan Chen, Xiaoling Liu, Changxiang Ye, Xuan Zhou, Ziqi Yang, Ziqiang Gong, Lizhang Chen, Tingting Wang
Summary: This research conducted a systematic and comprehensive meta-analysis to determine the association between maternal body mass index (BMI) and gestational weight gain (GWG) and the risk of cancer in offspring. The results suggest that high GWG may increase the risk of total cancer in offspring, while low GWG is not associated with the risk. There is no significant association between maternal underweight, overweight/obesity, and the risk of total cancer in offspring. Further research is needed to clarify the potential relevance of maternal BMI and GWG on offspring cancer, especially for specific cancers.
Review
Developmental Biology
Lawrence P. Reynolds, Wellison J. S. Diniz, Matthew S. Crouse, Joel S. Caton, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Developmental programming refers to the long-term changes in gene expression caused by stressors during development, which can affect organ structure and function. Maternal nutrition plays a crucial role in the developmental program. Future research should focus on the effects of developmental programming on the offspring's life course and subsequent generations, as well as utilizing the positive aspects of developmental programming.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2023)
Article
Health Care Sciences & Services
Stefano Nobile, Chiara Di Sipio Morgia, Giovanni Vento
Summary: The developmental origins of health and disease hypothesis suggests that early developmental exposures and fetal growth can influence the risk of chronic diseases in later periods. Factors such as genetics, environment, climate, and nutrition play important roles in this interaction. Premature birth and growth restriction are important factors considered by the hypothesis. Environmental factors such as pollution, stress, and drugs are also implicated in disease development. This hypothesis can explain the occurrence of multiple diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Camila Honorato A. Torres, Lidiane F. Schultz, Paul J. Veugelers, Silmara S. B. S. Mastroeni, Marco F. Mastroeni
Summary: The study found that maternal pre-pregnancy overweight and simultaneous excessive GWG were positively associated with elevated BP in 6-year-old children. Mothers with pre-pregnancy BMI ≥ 25 kg/m(2) and excessive GWG were more likely to have children with elevated diastolic blood pressure.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Clive J. J. Petry, Laurentya Olga, Ieuan A. A. Hughes, Ken K. K. Ong
Summary: Maternal iron supplementation during pregnancy may have an impact on newborn size and adiposity, but these effects disappear during infancy. However, there is some evidence to suggest that iron supplementation during pregnancy may have long-term effects on blood pressure in mid-childhood.