Review
Engineering, Biomedical
Marika Mosina, Ilijana Kovrlija, Liga Stipniece, Janis Locs
Summary: The functionalization of biomaterials, particularly calcium phosphates, plays a crucial role in enhancing lifestyle and modulating modern diseases. While previous studies have focused on the osteogenic differentiation of stem cells and bone progenitor cells, the aspect of antibacterial properties has been largely overlooked. This study provides a comprehensive overview of gallium containing calcium phosphates (GaCaPs), including their synthesis methods, antibacterial properties, and biocompatibility. The incorporation of gallium offers a potential solution to address the increasing antibiotic resistance of bacteria. A systematic approach is highly necessary to determine the recognition and feasibility of GaCaPs in the field of therapeutics.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
H. Maleki-Ghaleh, M. H. Siadati, A. Fallah, B. Koc, M. Kavanlouei, P. Khademi-Azandehi, E. Moradpur-Tari, Y. Omidi, J. Barar, Y. Beygi-Khosrowshahi, Alan P. Kumar, K. Adibkia
Summary: Bacteria can be effectively degraded by nanoparticles through electrostatic interactions, and incorporating antibacterial materials like zinc and graphene can further enhance bacterial degradation. Zinc-doped hydroxyapatite/graphene nanocomposite shows excellent antibacterial and bioactive properties for bone tissue engineering. The antibacterial activity along with cell biocompatibility and bioactivity make this nanocomposite highly desirable for bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Shuang Tong, Xu Sun, Anhua Wu, Shu Guo, Hangzhou Zhang
Summary: The study aimed to investigate the antibacterial properties and biocompatibility of TiO2 nanotubes loaded with HA and gentamicin. The results showed that the HA/TNT coating significantly reduced infection rates of implants, while gentamicin was released from the HA/TiO2 nanotubes for up to 22 days. The co-precipitation of gentamicin and HA using the TNT method provided a novel prophylactic approach against prosthetic infections and other biomedical applications.
Article
Polymer Science
Noureddine Akartasse, Khalil Azzaoui, Elmiloud Mejdoubi, Lhaj Lahcen Elansari, Belkhir Hammouti, Mohamed Siaj, Shehdeh Jodeh, Ghadir Hanbali, Rinad Hamed, Larbi Rhazi
Summary: This study aimed to purify water from toxic metals by preparing a composite film using hydroxyapatite, chitosan, and glycerol. The composite film exhibited a homogeneous and smooth surface, and showed effective adsorption of Cd2+ and Zn2+ ions from aqueous solutions. Physico-chemical characterization and adsorption studies demonstrated the promising potential of the composite film for industrial and biological applications.
Article
Polymer Science
Sara Perez-Davila, Carmen Potel-Alvarellos, Raquel Carballo, Laura Gonzalez-Rodriguez, Miriam Lopez-Alvarez, Julia Serra, Patricia Diaz-Rodriguez, Mariana Landin, Pio Gonzalez
Summary: The regeneration of bone and prevention of infections are two major challenges in the biomedical field. To address the need for bone regeneration, 3D printing technology combined with PLA and HA is being investigated to provide personalized and multifunctional scaffolds. To prevent infections, researchers are also exploring the incorporation of antibacterial drugs into biodegradable scaffolds.
Article
Materials Science, Coatings & Films
Heng He, Ke Li, Wei Luo, Zhengyuan Jiao, Fanrong Ai, Kui Zhou, Chuanliang Cao
Summary: This article investigates the preparation and performance of Ca-P pre-coating and polycaprolactone (PCL) composite coating on magnesium alloy substrate. The Ca-P pre-coating enhances the bonding strength of the PCL coating with the alloy substrate, preventing peeling and loss. Nanoparticles in the composite coating play important roles in increasing surface roughness, controlling matrix degradation rate, and improving antibacterial properties.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Negar Azizabadi, Parviz Aberoomand Azar, Mohammad Saber Tehrani, Pirouz Derakhshi
Summary: In this study, bioactive glass with zinc and silver content was synthesized via the sol-gel route. The results showed that the samples with higher zinc and silver content exhibited better bioactivity, antibacterial properties, and formation of hydroxyapatite. Among all the specimens, the sample BG-A2Z3 demonstrated optimal properties and is considered the most suitable candidate for orthopedic applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Polymer Science
Jinseok Kim, Siyoung Lee, Jinwook Park, Jong-Chan Lee
Summary: Polymer microspheres containing bio-based cardanol moiety were synthesized through suspension polymerization of 2-hydroxy-3-cardanylpropyl methacrylate (CM). The introduction of cardanol moiety endowed the microspheres with bactericidal properties, and the formation of a cross-linked structure during suspension polymerization increased their physical stability. The polymer microspheres and the resulting films exhibited high antibacterial activity against E.coli, with minimal inhibition concentration (MIC) values of 0.403 mg mL-1 and over 99.9%, respectively. Copolymer microspheres prepared by incorporating styrene (ST) with CM also demonstrated significant antibacterial activity, with an MIC value of 0.519 mg mL-1, along with high antibacterial performance in the resulting films. The antibacterial mechanism of the films was attributed to direct contact with the bacterial cell wall rather than leaching of antibacterial agents. Moreover, all polymeric films showed good biocompatibility regardless of their monomer composition.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Ceramics
Yuhua Zhu, Song Chen, Cunfang Zhang, Toshiyuki Ikoma, Hongmei Guo, Xinyan Zhang, Xiaona Li, Weiyi Chen
Summary: The study revealed that the microstructure and mechanical properties of porous gelatin/HAp scaffolds were significantly influenced by the preparation methods and scaffold types. The FD-gelatin/HAp scaffolds had a flat surface with a compressive strength of 24 MPa, while the DCPD-bound and HAp-bound gelatin/HAp microsphere scaffolds showed porous structures with compressive strengths of 50 MPa and 17 MPa respectively. In vitro biocompatibility tests indicated that all scaffolds supported cell attachment and proliferation, with notable differences in cell behavior based on the presence of a porous structure in the scaffolds.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Yamin Chai, Zhuang Liu, Yunzheng Du, Lichun Wang, Jinyan Lu, Qian Zhang, Wenyan Han, Tingting Wang, Yameng Yu, Lisha Sun, Lailiang Ou
Summary: A new class of nanocomposite adsorbents was successfully constructed with improved mechanical performance and high adsorption capacity, along with excellent biocompatibility. In vivo experiments in pig models confirmed the efficacy and biosafety of the adsorbent for direct removal of bilirubin from whole blood.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Mohd Faiz Mohd Yusoff, Noor Hayaty Abu Kasim, Wan Harun Himratul-Aznita, Syafiqah Saidin, Krishnamurithy Genasan, Tunku Kamarul, Zamri Radzi
Summary: This study synthesized silver-incorporated hydroxyapatite bioceramic material using a microwave-assisted wet precipitation method for the first time, demonstrating its convenience and cost-effectiveness. Physicochemical characterization, antibacterial activity, and biocompatibility of the Ag-HA composite were evaluated, showing promising results for biomedical applications.
MATERIALS CHARACTERIZATION
(2021)
Article
Materials Science, Multidisciplinary
Ionela Cristina Nica, Marcela Popa, Luminita Marutescu, Anca Dinischiotu, Simona Liliana Iconaru, Steluta Carmen Ciobanu, Daniela Predoi
Summary: In this study, novel antibacterial coatings containing hydroxyapatite nanoparticles doped with different concentrations of samarium were prepared, showing continuous and homogeneous layers with significant antibiofilm activity and good biocompatibility. The findings suggest that samarium doped hydroxyapatite coatings could be promising candidates for new antimicrobial strategies.
Review
Biotechnology & Applied Microbiology
Honggang Chi, Yunqi Qiu, Xiaoqing Ye, Jielin Shi, Ziyi Li
Summary: This paper reviews the recent progress in the preparation strategy and application of hydrogel microspheres in the field of skin repair. The preparation methods of hydrogel microspheres are summarized, and the related research progress in skin repair is discussed, focusing on bioactive, antibacterial, hemostatic, and delivery platform microspheres. The limitations and future prospects of hydrogel microspheres in skin repair are presented, aiming to provide valuable references for further development and application of hydrogel microspheres.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiao Han, Yan Chen, Qian Jiang, Xin Liu, Yaming Chen
Summary: A novel bioactive glass (BAG)-modified hybrid composite resin has been developed, showing excellent mechanical properties, good biocompatibility, antibacterial and remineralizing capabilities. The balance between mechanical properties, toxicity, antibacterial activity, and bioactivity makes it a promising prospect for clinical application. The release of bioactive ions (Ca2+, Si4+) plays a key role in antibacterial and remineralizing activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Zheng Wang, Li Mei, Xinqiang Liu, Qihui Zhou
Summary: Hierarchically hybrid biocoatings on Ti implants are developed in this study by incorporating polydopamine, ZnO nanoparticles, and chitosan/nanocrystal hydroxyapatite. These coatings enhance antibacterial activity and osteogenesis, offering a promising alternative for developing Ti implants with long-lifetime bioactivity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
