Article
Multidisciplinary Sciences
Alexandra N. Rindone, Xiaonan Liu, Stephanie Farhat, Alexander Perdomo-Pantoja, Timothy F. Witham, Daniel L. Coutu, Mei Wan, Warren L. Grayson
Summary: Vascularization plays a critical role in cranial bone growth, maintenance, and healing. The study utilized a quantitative imaging platform to analyze the spatial relationship between blood vessels and skeletal progenitors in the murine calvarium, demonstrating specific vessel types are spatially correlated with skeletal progenitors during various cranial processes. Furthermore, the findings suggest a potential role for osteoclasts in maintaining the native cranial microvascular environment.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Yuning Zhou, Yue Hu, Mamoru Uemura, Lunguo Xia, Xingge Yu, Yuanjin Xu
Summary: Strontium-substituted calcium silicate/silk fibroin composite materials have significant effects on the proliferation, osteogenic differentiation, and angiogenic factor secretion of rat bone marrow-derived mesenchymal stromal cells (rBMSCs), and can promote new bone formation in a rat calvarial defect model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Mingming Wang, Hongyan Zhan, Jianhua Wang, Hua Song, Jianhua Sun, Gang Zhao
Summary: This study demonstrates that CS can enhance the proliferation of ADSCs and improve their migration ability through inhibiting apoptosis and oxidative stress. CS also promotes the expression of CXCR4 in ADSCs and enhances their migration and angiogenic capacity. Importantly, CS improves the efficacy of ADSCs in wound healing both in vivo and in vitro, providing potential materials for the treatment of wound healing.
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Soomin Lee, Zheng Li, Dehua Meng, Qinming Fei, Libo Jiang, Tengfei Fu, Z. E. Wang, Shuhao Liu, Jian Zhang
Summary: Silicon-mediated macrophage polarization plays a crucial role in vascularization, and CPC-CS can promote macrophage polarization and accelerate endothelial neovascularization. Silicon released from CPC-CS can promote M2 macrophage polarization during bone repair.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Materials Science, Biomaterials
Xinyuan Yuan, Tingting Wu, Teliang Lu, Jiandong Ye
Summary: In this study, Zn/Sr-doped calcium silicate/calcium phosphate cements were prepared to enhance bone regeneration. The doping of Zn and Sr had little effect on the physicochemical properties of the cements, but it significantly promoted osteogenesis. Among the different compositions, 10Zn/20Sr-CS/CPC showed the best in vitro osteogenic performance.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Ceramics
Tingting Wu, Teliang Lu, Haishan Shi, Jinchao Wang, Jiandong Ye
Summary: Introducing silicon (Si) and strontium (Sr) ions into calcium phosphate cement (CPC) using strontium doped calcium silicate (Sr-CS) can enhance osteogenesis and angiogenesis while suppressing osteoclastogenesis, making it a promising strategy for osteoporotic bone repair. In this study, the 20Sr-CS/CPC extract showed increased proliferation, ALP activity, osteogenesis-related gene and protein expression, as well as enhanced angiogenesis and suppressed osteoclastogenesis. It has great potential for stimulating osteoporotic bone regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Petra Wolint, Lukas Naf, Desiree Schibler, Nora Hild, Wendelin J. Stark, Pietro Giovanoli, Maurizio Calcagni, Johanna Buschmann
Summary: The study investigates the use of calcium phosphate nanoparticles to induce stem cells towards bone cell differentiation, showing potential for osteogenic and endothelial commitment.
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Physical
Yemi Kim, Donghee Lee, Minjoo Kye, Yun-Jae Ha, Sin-Young Kim
Summary: Using premixed calcium silicate-based cements and fast-set cements as retrograde filling materials can facilitate satisfactory biological responses and demonstrate comparable osteogenic potential to ProRoot MTA.
Article
Engineering, Biomedical
Panyu Zhou, Demeng Xia, Zhexin Ni, Tianle Ou, Yang Wang, Hongyue Zhang, Lixia Mao, Kaili Lin, Shuogui Xu, Jiaqiang Liu
Summary: Immune reactions, especially macrophage polarization, play a crucial role in bone formation and repair after implanting bone substitute materials. Calcium silicate (CS) bioceramics can promote osteogenesis by inducing M2 macrophage polarization, enhancing osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The findings suggest potential strategies to enhance the in vitro osteogenesis capability of bone substitute materials.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Teliang Lu, Jing Zhang, Xinyuan Yuan, Chenyu Tang, Xiaolan Wang, Yu Zhang, Kun Xiong, Jiandong Ye
Summary: The study incorporated zinc and silicate ions into calcium phosphate cement to obtain zinc silicate-modified CPCs with different contents. The addition of ZS increased compressive strength, prolonged setting time, and densified the structure of CPC. ZS/CPCs significantly promoted osteogenesis and angiogenesis, while restricting osteoclastogenesis, providing an appropriate microenvironment for immune cells.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Feng Wang, Huijuan Qian, Lingchi Kong, Wenbo Wang, Xiaoyu Wang, Ze Xu, Yimin Chai, Jia Xu, Qinglin Kang
Summary: Astragaloside IV (AS-IV) accelerates bone regeneration during distraction osteogenesis by enhancing osteogenesis and preosteoclast-induced angiogenesis simultaneously, partially through AKT/GSK-3 beta/beta-catenin signaling. These findings suggest that AS-IV may serve as a potential bioactive molecule for promoting the coupling of osteogenesis and angiogenesis, and imply that AKT/GSK-3 beta/beta-catenin signaling may be a promising therapeutic target for patients during distraction osteogenesis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Darwin Kurniawan, Jacob Mathew, Michael Ryan Rahardja, Hoang-Phuc Pham, Pei-Chun Wong, Neralla Vijayakameswara Rao, Kostya (Ken) Ostrikov, Wei-Hung Chiang
Summary: This study reports the development of smart anticancer drug nanocarriers through plasma engineering technique. The nanocarriers containing chitosan and nitrogen-doped graphene quantum dots can release drugs in a pH-responsive manner and exhibit enhanced toughness. The loaded nanocarriers demonstrate improved drug loading capability and stable release, showing great potential in cancer treatment.
Review
Multidisciplinary Sciences
Farrokhfar Valizadeh Harzand, Seyyed Navid Mousavi Nejad, Aziz Babapoor, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Wei-Hung Chiang, Maria Giovanna Buonomenna, Chin Wei Lai
Summary: Metal-organic frameworks (MOFs) are porous crystalline materials composed of metal and organic material, with properties such as tunability, large surface area, and high porosity. They have various applications in environmental protection, biosensors, regenerative medicine, medical engineering, cell therapy, catalysts, and drug delivery. MOF-based asymmetric membranes improve stability and specificity, while conjugated membranes increase the area of functional groups, making them attractive for drug and biosensor fabrication. MOF-assisted membranes provide a platform with different properties and characteristics for biomedical applications. The latest version of MOF materials/membranes has potential applications in medical engineering, cell therapy, drug delivery, and regenerative medicine.
Article
Environmental Sciences
Atefeh Moridi, Samad Sabbaghi, Jamal Rasouli, Kamal Rasouli, Seyyed Alireza Hashemi, Wei-Hung Chiang, Seyyed Mojtaba Mousavi
Summary: Nowadays, hospital wastewater poses a significant threat to the environment and living organisms due to the high concentration of toxic pharmaceutical contaminants. This study developed a low-cost and eco-friendly nano adsorbent (nZVI/copper slag) to remove a specific toxic contaminant, Cefixime, from wastewater. The optimal conditions and efficient removal rate were determined using Response Surface Methodology (RSM) and various characterization techniques. The results showed the potential of the nano adsorbent for effective and repeated removal of Cefixime, making it a promising solution for wastewater treatment.
Review
Environmental Sciences
Zahra Pouramini, Seyyed Mojtaba Mousavi, Aziz Babapoor, Seyyed Alireza Hashemi, Nelson Pynadathu Rumjit, Shivani Garg, Shakeel Ahmed, Wei-Hung Chiang
Summary: The increase in pollutants entering water resources due to population growth and industrialization has become a global health concern. MXene materials have shown the capability to adsorb heavy contaminants and are well suited as adsorbents for waste removal. This review article introduces MXene nanocomposites for water remediation, discusses their applications, and reviews their effects on water and wastewater contaminants degradation. Future trends in MXene-based nanocomposites for water treatment and environmental applications are also discussed.
Review
Chemistry, Analytical
Ahmad Gholami, Seyyed Mojtaba Mousavi, Reza Masoumzadeh, Mojtaba Binazadeh, Kamran Bagheri Lankarani, Navid Omidifar, Omid Arjmand, Wei-Hung Chiang, Mohsen Moghadami, Nelson Pynadathu Rumjit
Summary: There are various treatment protocols for acute viral hepatitis, and prompt recognition of the disease is crucial. Public health measures rely on accurate and timely diagnosis. However, existing diagnostic methods are expensive and there is a lack of adequate public health infrastructure for controlling viral hepatitis. Nanotechnology offers a potential solution by reducing screening costs and improving diagnostic accuracy. This review focuses on the use of three-dimensional carbon nanomaterials, such as graphene oxide and nanotubes, in the diagnosis and treatment of hepatitis due to their unique properties. It explores their potential contribution to effective tissue transfer and emphasizes the importance of rapid diagnosis for successful treatment. The future role of nanoparticles in the rapid diagnosis and treatment of viral hepatitis is expected to be better determined.
Article
Engineering, Chemical
Yi-Jui Yeh, Jinn P. Chu, Jhen-De You, Ting-Hao Chang, Jr Rong Liou, Wei-Hung Chiang, Pakman Yiu, Chun-Hway Hsueh, Yu-Lin Shen, Kuo-Lun Tung
Summary: This study demonstrates the use of a stainless-steel nano-pyramid structure coated on a mixed cellulose ester membrane for the separation of oil/water emulsions. The coated membrane exhibited superhydrophilicity, antifouling properties, and underwater superoleophobicity. It achieved a high separation efficiency of >99% for various light oil-water emulsions. The fabrication process of the coated membrane is also scalable and suitable for industrial applications.
Article
Chemistry, Analytical
Masoomeh Yari Kalashgrani, Aziz Babapoor, Seyyed Mojtaba Mousavi, Solmaz Feizpoor, Seyyed Alireza Hashemi, Mojtaba Binazadeh, Wei-Hung Chiang, Chin Wei Lai
Summary: The performance of IRMOF-3 for removing naphthalene from aqueous media is evaluated for the first time in this study. IRMOF-3 shows high adsorption capacity for naphthalene removal, with an optimum removal efficiency of 80.96% at specific conditions. The results demonstrate that IRMOF-3 is an effective adsorbent for naphthalene removal from wastewater.
Article
Nanoscience & Nanotechnology
Yi-Jui Yeh, Chia-Jung Cho, Jean-Sebastien Benas, Kuo-Lun Tung, Chi-Ching Kuo, Wei-Hung Chiang
Summary: We developed a simple and environmentally friendly method to fabricate stretchable porous metal-organic nanocomposites with exceptional SERS enhancement and mechanical stability. These nanocomposites showed outstanding SERS enhancement and wide detection range for cancer biomarkers.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yu-Chi Lin, Mia Rinawati, Wei-Hsiang Huang, Sofiannisa Aulia, Ling-Yu Chang, Yi-Ting Guo, Kuan-Jung Chen, Wei-Hung Chiang, Shu-Chih Haw, Min-Hsin Yeh
Summary: Dissolved oxygen (DO) is a crucial parameter for water quality assessment, and this study reports N-doped reduced graphene oxide (N-rGO) as a self-antibiofouling DO sensor. By introducing N doping, the electron network of graphene can be reoriented, leading to improved selectivity and efficiency. Moreover, N-rGO can be integrated into a wireless DO monitoring device for aquatic fish farming.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Yi-Jui Yeh, Jr Rong Liou, Wei Lin, Kuo-Lun Tung, Wei-Hung Chiang
Summary: This study demonstrates an effective plasma engineering method to create nitrogen-doped graphene quantum dot (NGQD)-inorganic nanocomposites for tunable molecular separation. The composite materials show high separation efficiency and controllable nanopore structures, making them potentially valuable for various applications.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Review
Chemistry, Analytical
Seyyed Mojtaba Mousavi, Masoomeh Yari Kalashgrani, Ahmad Gholami, Navid Omidifar, Mojtaba Binazadeh, Wei-Hung Chiang
Summary: The COVID-19 pandemic has created a demand for fast and efficient point-of-care diagnostic tools. Existing methods lack sensitivity and are time-consuming. Point-of-care testing (POCT) using quantum dots (QDs) coupled with antibodies offers rapid and highly sensitive detection of viral antigens. Quantum dot-based lateral flow immunoassays (LFIA) are emerging as a promising alternative to overcome the limitations of conventional LFIA. This review highlights the advancements in QD-based LFIA for rapid COVID-19 diagnosis, exploring strategies to enhance sensitivity and examining its published performance. The integration of quantum dots with LFIA holds immense potential in revolutionizing COVID-19 detection, treatment, and prevention.
Article
Chemistry, Analytical
Michael Ryan Rahardja, Darwin Kurniawan, Wei-Hung Chiang
Summary: In this study, we report the microplasma synthesis of nitrogen-doped graphene quantum dots (N-GQDs) for the fluorescence-based detection of 4-nitrophenol (4-NP). By utilizing Forster resonance energy transfer (FRET) between the donor N-GQDs and the acceptor 4-NP, synthesized N-GQDs can effectively detect 4-NP in a range of 0.5 to 100 μM with a low limit of detection (95.14 nM). This work provides a simple, fast, and environmentally friendly method for synthesizing N-GQDs usable in environmental nanosensors.
Article
Chemistry, Analytical
Wesley Wei -Wen Hsiao, Gianna Fadhilah, Cheng-Chung Lee, Ryu Endo, Yu-Jou Lin, Stefanny Angela, Chia-Chi Ku, Huan-Cheng Chang, Wei -Hung Chiang
Summary: Avian influenza virus (AIV), a zoonotic virus, can infect humans with a high mortality rate. The development of rapid, selective, and accurate detection methods is crucial. Nanotechnology provides a promising approach as nanomaterial-based biosensors offer eco-friendly, portable, and sensitive diagnostic systems with a low detection limit. This paper reviews advanced nanomaterial-based biosensors for AIV detection and discusses potential trial protocols and key issues in their development.
Review
Chemistry, Physical
Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Masoomeh Yari Kalashgrani, Ahmad Gholami, Mojtaba Binazadeh, Wei-Hung Chiang, Mohammed M. Rahman
Summary: Graphene oxide (GO) has the potential to enhance the performance and energy storage capabilities of supercapacitors (SCs) due to its exceptional properties. GO's electrical conductivity, high surface area, and mechanical strength make it an ideal material for SC electrodes, leading to improved capacitance and charge-discharge rates. GO-based SCs demonstrate superior energy and power densities, long-term stability, and cost-effectiveness, making them a promising alternative to conventional energy storage systems.
SUSTAINABLE ENERGY & FUELS
(2023)
Article
Chemistry, Multidisciplinary
Yi-An Chen, Ming-You Shie, Chia-Che Ho, Sheng-Wen Ye, I. -Wen Peter Chen, Yu-Yin Shih, Yu-Fang Shen, Yi-Wen Chen
Summary: This study presents a novel immunosensor design strategy for non-invasive detection of the HSP70 biomarker. The immunosensor demonstrates high sensitivity and a good linear response, making it suitable for early detection and monitoring therapeutic response during anticancer therapy.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)