Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Physical
Hee-Yeon Kim, Byung-Hoon Kim, Myung-Sun Kim
Summary: This study investigates the surface characterization and pre-osteoblast biological behaviors of a 3D poly(ε-caprolactone)/beta-tricalcium phosphate scaffold modified by amine plasma-polymerization. The results demonstrate that the scaffold treated with DACH plasma-polymerization exhibits the highest bioactivity, making it a promising candidate for pre-osteoblast osteoblast differentiation.
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Lingfei Xiao, Minhao Wu, Feifei Yan, Yuanlong Xie, Zhibo Liu, Huayi Huang, Zhiqiang Yang, Shiyi Yao, Lin Cai
Summary: The treatment and repair of large bone defects is a major challenge in clinical settings. 3D-mineralized polycaprolactone nanofiber scaffolds with radially interconnected macrochannels and aligned nanofibers have shown significant potential in guiding cell arrangement and promoting tissue regeneration, especially for bone tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Multidisciplinary
Lin Zou, Le Hu, Panpan Pan, Solaiman Tarafder, Mingzu Du, Yusheng Geng, Gan Xu, Li Chen, Jingdi Chen, Chang H. Lee
Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Markus Laubach, Buddhi Herath, Nathalie Bock, Sinduja Suresh, Siamak Saifzadeh, Bronwin L. Dargaville, Jacqui McGovern, Marie-Luise Wille, Dietmar W. Hutmacher, Flavia Medeiros Savi
Summary: This study explores the use of Voronoi tessellation design in 3D-printed mPCL-HA composite scaffolds for scaffold-guided bone regeneration (SGBR). The results suggest that the Voronoi design allows for slow degradation and high osteogenicity, promoting tissue regeneration and bone formation without adverse reactions. The mPCL-HA Voronoi scaffolds have the potential for further preclinical animal studies before clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
P-C Chang, Z-J Lin, H-T Luo, C-C Tu, W-C Tai, C-H Chang, Y-C Chang
Summary: Recent research has focused on developing scaffolds with intricate configurations and manipulating extracellular matrix stiffness towards osteogenesis for maxillofacial defect regeneration. The study proposed infusing a degradable RGD-functionalized alginate matrix (RAM) with osteoid-like stiffness into a rigid 3D-printed hydroxyapatite scaffold. In vitro and in vivo results showed that RAM with osteoid-like stiffness, particularly when oxidized, significantly enhanced bone marrow stem cell viability, migration, and osteogenic differentiation, ultimately promoting robust bone formation in maxillofacial regeneration.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maryam Ataie, Jhamak Nourmohammadi, Ehsan Seyedjafari
Summary: A novel bioactive composite scaffold consisting of polycaprolactone and kappa-carrageenan was developed for bone regeneration. By coating the 3D printed PCL scaffold with carboxymethyl kappa-carrageenan and modifying the soaking process, calcium and strontium phosphate layers were created on the scaffold surface. The incorporation of strontium improved the scaffold's crystallinity and compressive strength, and enhanced the attachment, viability, and osteogenic differentiation of mesenchymal stem cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Jie Shen, Bo Chen, Xinyun Zhai, Wei Qiao, Shuilin Wu, Xuanyong Liu, Ying Zhao, Changshun Ruan, Haobo Pan, Paul K. Chu, Kenneth M. C. Cheung, Kelvin W. K. Yeung
Summary: The study examines the impact of magnesium ions on tissue microenvironment on bone regeneration, showing that moderate magnesium ion content promotes bone formation while absence or excessive magnesium ions inhibit it. The migration of magnesium ions plays a crucial role in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Sonia Sahvieh, Ahmad Oryan, Shadi Hassanajili, Amir Kamali
Summary: The study found that stem cell-loaded PLA/PCL/HA scaffolds showed better results in bone healing, assisting in bone tissue regeneration and healing. The experimental results demonstrated significant improvements in biomechanics, immunohistochemistry, and radiological evaluations in the BMSCs-loaded scaffold group, indicating higher levels of bone regeneration.
CELL AND TISSUE RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Xuanwen Xu, Yi Zhou, Kai Zheng, Xinyu Li, Lu Li, Yan Xu
Summary: Periodontitis is a chronic inflammatory disease that affects people worldwide and has an uncertain prognosis with surgical treatment. In this study, a three-dimensional scaffold made of electrospun polycaprolactone/gelatin fibrous membranes was developed to overcome the challenges of periodontal treatment. The scaffold showed good properties and promoted adhesion and proliferation of human periodontal ligament stem cells. In vivo experiments confirmed that the scaffold could guide cellular orientation and potentially facilitate periodontal regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yihan Wang, Changnan Xie, Zhiming Zhang, Haining Liu, Haixia Xu, Ziyue Peng, Chun Liu, Jianjun Li, Chengqiang Wang, Tao Xu, Lixin Zhu
Summary: In this study, a novel integrated bionic oxygenated scaffold was successfully fabricated using low-temperature molding 3D printing technology. The scaffold exhibited excellent mechanical properties and bionic hierarchical porous structures. It could release sustained oxygen and significantly enhance the survival, growth, and osteogenic differentiation of stem cells under hypoxia. The scaffold also facilitated efficient bone repair in a rabbit calvarial defect model. This research provides a promising clinical strategy for bone defect repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Hairui Suo, Yu Chen, Jiali Liu, Ling Wang, Mingen Xu
Summary: A novel biphasic scaffold was designed and fabricated using HAp and PCL through a multi-nozzle 3D printing technique, showing mechanical properties between pure HAp and PCL scaffolds. Finite element simulation demonstrated a biomimetic strengthened structure of the biphasic scaffold under compression, suitable for osteochondral tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Minglei Yang, Weiyan Sun, Long Wang, Hai Tang, Xiang Xu, Liangwei Yang, Junjun Ni, Kuoen Zheng, Xu Jiang, Weiwen Xu, Guofang Zhao, Yunlang She, Lei Zhang, Dong Xie, Chang Chen
Summary: This study successfully promoted tracheal cartilage regeneration and tracheal defect repair using the Cur/PCL scaffold, demonstrating significant anti-inflammatory effects and improved survival rates in experimental rabbits.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Chen Yang, Zhiwei Zheng, Muhammad Rizwan Younis, Chenle Dong, Yahong Chen, Shan Lei, Dong-Yang Zhang, Jiayingzi Wu, Xueqing Wu, Jing Lin, Xiansong Wang, Peng Huang
Summary: A multifunctional scaffold for diabetic bone defect has been developed, with properties including osteogenesis, angiogenesis, and anti-inflammation. Enzyme functionalization and mineralization were key strategies in addressing the high risk of fractures and poor bone healing ability in diabetic patients. The scaffold showed promising outcomes in enhancing bone tissue regeneration in in vitro and in vivo studies, highlighting the potential of multifunctional scaffolds for diabetic bone regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Medicinal
Bahare Salehi, Cristina Quispe, Javad Sharifi-Rad, Lalit Giri, Renu Suyal, Arun K. Jugran, Paolo Zucca, Antonio Rescigno, Stefania Peddio, Otilia Bobis, Adela Ramona Moise, Gerardo Leyva-Gomez, Maria L. Del Prado-Audelo, Hernan Cortes, Marcello Iriti, Miquel Martorell, Natalia Cruz-Martins, Manoj Kumar, Wissam Zam
Summary: The Cucurbitaceae family, with its rich sources of phytochemicals, demonstrates various pharmacological effects including antioxidant, antitumor, and antidiabetic properties. Numerous studies have shown the health benefits of Cucurbita species for different human disorders related to oxidative stress.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Gitishree Das, Han-Seung Shin, Gerardo Leyva-Gomez, Maria L. Del Prado-Audelo, Hernan Cortes, Yengkhom Disco Singh, Manasa Kumar Panda, Abhay Prakash Mishra, Manisha Nigam, Sarla Saklani, Praveen Kumar Chaturi, Miquel Martorell, Natalia Cruz-Martins, Vineet Sharma, Neha Garg, Rohit Sharma, Jayanta Kumar Patra
Summary: Interest in the Cordyceps genus has increased due to its immunostimulatory potential, with various pharmacological activities reported in pre-clinical studies. The bioactive compounds present in Cordyceps have been linked to its diverse properties, including immune stimulation and potential therapeutic benefits.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sergio A. Bernal-Chavez, Maria Luisa Del Prado-Audelo, Isaac H. Caballero-Floran, David M. Giraldo-Gomez, Gabriela Figueroa-Gonzalez, Octavio D. Reyes-Hernandez, Manuel Gonzalez-Del Carmen, Maykel Gonzalez-Torres, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Nanoparticles have great potential for various biomedical applications, but their in vivo use requires sterility. Different sterilization methods can impact the physicochemical properties of nanoparticles.
Article
Pharmacology & Pharmacy
Maria Luisa Del Prado-Audelo, Adriana Estela Hernandez-Tenorio, Maykel Gonzalez-Torres, Jonathan J. Magana, Roberto Sanchezsanchez, Maria Del Pilar Granada-Macias, Silvestre Ortega-Pena, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Chitosan, a natural polymer with antibacterial and antifungal properties, modified by gamma irradiation and combined with cinnamon oil and disodium EDTA, showed promising antimicrobial effects against E. coli, P. aeruginosa, C. albicans, and S. aureus, making it a potential alternative treatment for chronic wounds.
Review
Dermatology
Hernan Cortes, Martin Rojas-Marquez, Maria L. Del Prado-Audelo, Octavio D. Reyes-Hernandez, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez
Summary: The presence of skin lesions in visible areas can lead to emotional distress such as low self-worth, embarrassment, and social isolation for patients. Mental health care for dermatological patients is crucial in managing skin diseases effectively.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Review
Polymer Science
Maria Luisa Del Prado-Audelo, Isaac H. Caballero-Floran, Nestor Mendoza-Munoz, David Giraldo-Gomez, Javad Sharifi-Rad, Jayanta Kumar Patra, Maykel Gonzalez-Torres, Benjamin Floran, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Research on self-healable polymers for medical purposes has gained momentum in the past 20 years, with a focus on applications in tissue engineering. Natural and synthetic polymers each have their own advantages when it comes to developing self-healing hydrogels, which can be tailored based on specific requirements. The fabrication methods for self-healing hydrogels, including covalent and non-covalent crosslinking, play a crucial role in determining the properties and potential applications of these materials in the biomedical field.
IRANIAN POLYMER JOURNAL
(2022)
Article
Physics, Condensed Matter
J. S. Narro-Rios, I. Garduno-Wilches, G. Alarcon-Flores, C. A. Ruiz-Rojas, K. Gomez-Lizarraga, M. Aguilar-Frutis
Summary: A CuCrO2/ZnO heterojunction diode was successfully fabricated and characterized by various measurements, showing high quality and performance that allows it to be classified and used as a semi-transparent diode.
PHYSICA B-CONDENSED MATTER
(2022)
Review
Chemistry, Physical
Hernan Cortes, Hector Hernandez-Parra, Sergio A. Bernal-Chavez, Maria L. Del Prado-Audelo, Isaac H. Caballero-Floran, Fabiola Borbolla-Jimenez, Maykel Gonzalez-Torres, Jonathan J. Magana, Gerardo Leyva-Gomez
Summary: Surfactants play a crucial role in the manufacturing of polymeric nanoparticles, reducing emulsion droplet size and ensuring stability. Different non-ionic surfactants have varying applicability and biocompatibility, while also impacting pharmacokinetics beyond nanoparticle dispersion stabilization.
Review
Pharmacology & Pharmacy
Maria Luisa Del Prado-Audelo, Hernan Cortes, Isaac H. H. Caballero-Floran, Maykel Gonzalez-Torres, Lidia Escutia-Guadarrama, Sergio A. A. Bernal-Chavez, David M. M. Giraldo-Gomez, Jonathan J. J. Magana, Gerardo Leyva-Gomez
Summary: Terpenes, organic compounds mainly derived from plants and trees, demonstrate attractive biological properties such as analgesic and anti-inflammatory activities. Studies have shown that terpenes can reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines. The search for novel therapeutic treatments based on terpenes is gaining attention due to the side effects associated with traditional anti-inflammatory drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fabiola Borbolla-Jimenez, Maria Luisa Del Prado-Audelo, Bulmaro Cisneros, Isaac H. Caballero-Floran, Gerardo Leyva-Gomez, Jonathan J. Magana
Summary: SCAs are primarily caused by pathological aggregation of polyglutamine (polyQ) proteins and intracellular inclusions, leading to neurodegenerative diseases. Current treatment for SCAs is limited to symptomatic intervention, but gene therapy and nanotechnology may offer promising therapeutic approaches.
Review
Biochemistry & Molecular Biology
Javad Sharifi-Rad, Cristina Quispe, Zhazira Mukazhanova, Ewa Knut, Aknur Turgumbayeva, Aliya Kipchakbayeva, Gulnaz Seitimova, Mohamad Fawzi Mahomoodally, Devina Lobine, Aaron Koay, Jinfan Wang, Helen Sheridan, Gerardo Leyva-Gomez, Maria L. Del Prado-Audelo, Hernan Cortes, Antonio Rescigno, Paolo Zucca, Oksana Sytar, Muhammad Imran, Celia F. Rodrigues, Natalia Cruz-Martins, Halina Ekiert, Manoj Kumar, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Agnieszka Szopa
Summary: Resveratrol, a polyphenolic stilbene derivative found in grapes and red wine, has shown potential in cancer therapy with its antioxidant, anti-inflammatory, and antiaging abilities. Nanoformulations of resveratrol could improve its efficiency in cancer treatment, making it a promising strategy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Sergio Alberto Bernal-Chavez, Sergio Alcala-Alcala, Maykel Gonzalez-Torres, Maria Luisa Del Prado-Audelo, Gerardo Leyva-Gomez
Summary: The development of a self-healing PG-150 distearate-PVA hydrogel with higher crystallinity and adequate chemical and mechano-responsive properties in this study makes it suitable for soft tissue engineering, allowing deformation under low levels of mechanical stress.
Article
Chemistry, Multidisciplinary
Karla Gomez-Lizarraga, Ismael Garduno-Wilches, Jorge Narro-Rios, Cristina Pina-Barba, Miguel Aguilar-Frutis, Gilberto Alarcon-Flores
Summary: In this study, the drying and photopolymerization processes of nanoparticles embedded in a photopolymerized methacrylated gelatin were investigated using steady-state and time-resolved luminescence spectroscopy. The presence of methacrylated gelatin affected the quantum yield and decay time of the nanoparticles, and a concentration of 1-3% w/V was required for luminescence to be observed without significant quenching.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Review
Polymer Science
Alejandra Romero-Montero, Jose Luis Valencia-Bermudez, Samuel A. Rosas-Melendez, Israel Nunez-Tapia, Maria Cristina Pina-Barba, Gerardo Leyva-Gomez, Maria Luisa Del Prado-Audelo
Summary: The increment in water pollution due to industrial development is a global concern. Aerogels, specifically polymer-based aerogels, show promising potential in water remediation due to their high porosity and adsorption capacity. Natural biopolymeric aerogels, such as cellulose, chitosan, and alginate, have been proven effective in removing pollutants like dyes, oil, and pharmaceuticals from water.
Article
Biochemistry & Molecular Biology
Maria Luisa Del Prado-Audelo, Francisco J. Gomez-Zaldivar, Mario Perez-Diaz, Roberto Sanchez-Sanchez, Maykel Gonzalez-Torres, Manuel Gonzalez-Del Carmen, Gabriela Figueroa-Gonzalez, Javad Sharifi-Rad, Octavio D. Reyes-Hernandez, Hernan Cortes, Gerardo Leyva-Gomez
Summary: The hydrogel composed of elastin and polyvinylpyrrolidone obtained through a novel method exhibited suitable morphology for wound dressing applications, showing high biocompatibility with human dermal fibroblasts. This suggests that the cross-linking of elastin with PVP is a promising strategy for biological wound healing applications.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)