Article
Chemistry, Physical
Mariana Brito da Cruz, Joana Faria Marques, Neusa Silva, Sara Madeira, Oscar Carvalho, Filipe Samuel Silva, Joao Carames, Antonio Mata
Summary: This study evaluated the response of periodontal hard tissue and soft tissue cells to microgroove-milled zirconia surfaces. The results showed that the milled microgroove texture did not affect the viability of gingival and bone cells, but it seemed to influence the cellular differentiation of osteoblasts.
Article
Materials Science, Multidisciplinary
Vinicius Richieri Manso Goncalves, Ihsan Caha, Alexandra Cruz Alves, Fatih Toptan, Luis Augusto Rocha
Summary: Novel in-situ Ti-based matrix composites were developed through reactive hot pressing. These composites have a metallic matrix composed of β-Ti phase and reinforcing phase Ti2C, exhibiting excellent corrosion and tribocorrosion behavior. The formation of the reinforcing phase can decrease the corrosion tendency and improve the tribocorrosion behavior of the composites.
Article
Materials Science, Multidisciplinary
Ahmad Farrahnoor, Hussain Zuhailawati
Summary: By varying the content of HA in titanium-niobium-hydroxyapatite composite, the bioactivity of the material can be adjusted, with the most significant impact observed at 15% HA content. The decomposition of HA was found to enhance bioactivity, and the formation of apatite on the surface of the composite accelerated this process.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Inmaculada Tendero, Mariana Correa Rossi, Mauricio Viera, Jose Manuel Amado, Maria Jose Tobar, Angel Vicente, Armando Yanez, Vicente Amigo
Summary: The study focused on the impact of laser surface modification on Ti-Nb-Mo alloys, revealing promising possibilities for the biomedicine field. Samples without surface treatment displayed deteriorated properties against corrosion and ion release.
Article
Engineering, Multidisciplinary
Mariana Brito da Cruz, Joana Faria Marques, Ana Filipa Silva Marques, Sara Madeira, Oscar Carvalho, Filipe Silva, Joao Carames, Antonio Duarte Sola Pereira da Mata
Summary: The aim of this study was to evaluate the response of gingival fibroblasts and human osteoblasts to textured Nd:YAG laser microgrooves with different dimensions on zirconia implant surfaces. The results showed that there were no significant differences in cell viability and differentiation between different microtopographic laser grooves and the traditional sandblasting and acid-etching surface treatment.
Article
Multidisciplinary Sciences
Adrianna Budzinska, Lukasz Galganski, Wieslawa Jarmuszkiewicz
Summary: Nitrogen-containing bisphosphonates (NBPs), commonly used in the treatment of bone disorders, have been found to cause endothelial dysfunction, oxidative stress, and mitochondrial impairment in cultured human endothelial cells. These drugs reduce cell viability, induce inflammation, and disrupt the cellular energy state and mitochondrial respiratory function.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Manufacturing
Robert Williams, Matthew Bilton, Neil Harrison, Peter Fox
Summary: This study investigated the impact of oxidized particles on part integrity and mechanical failure, finding that these particles negatively affect the mechanical properties of the final build. Unless these particles can be removed from recycled feedstock, their effects will limit the reuse of powder, especially in safety critical industries.
ADDITIVE MANUFACTURING
(2021)
Article
Materials Science, Multidisciplinary
J. C. Wang, Y. J. Liu, S. X. Liang, Y. S. Zhang, L. Q. Wang, T. B. Sercombe, L. C. Zhang
Summary: This study investigates the microstructure and mechanical behavior of Ti-35Nb alloy components manufactured using different types of powder feedstock, highlighting the importance of powder feedstock on the melt pool stability and resultant part's microstructure and mechanical properties.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Grzeczkowicz, Monika Drabik, Agata Lipko, Pawel Bacal, Angelika Kwiatkowska, Beata Kazimierczak, Ludomira H. Granicka
Summary: The study developed multifunctional polyelectrolyte layers enhanced with hydroxyapatite nanoparticles, gold nanoparticles (AuNPs), and/or fullerenol nanocomposites for wound dressings on the bone-skin interface. Constructed shells were examined using TEM, STEM, and EDX techniques, with human osteoblasts or fibroblasts immobilized within. Involvement of fullerenol and/or hydroxyapatite nanoparticles influenced the immobilized cell systems morphology, with membranes observed to block the internalization of AuNPs.
Article
Chemistry, Physical
Xianlei Hu, Qincheng Xie, Yi Yuan, Ying Zhi, Xianghua Liu
Summary: SiC particle-reinforced Ti/Al/Ti clad plates were successfully fabricated by the powder-in-tube method. The presence of SiC particles significantly enhanced the diffusion of Ti and Al elements, while the diffusion width of the intermetallic compound increased with the size of SiC particles. The optimized diffusion thickness of the Ti/Al-SiC/Ti clad plate's IMC layer was approximately 4.5 μm. The 1 μm SiC-reinforced Ti/Al/Ti clad plate exhibited the best mechanical properties after annealing and hot rolling, with a peeling strength of 31.5 N/mm, ultimate tensile strength of 305 MPa, and elongation of 26%. The presence of compact and homogenous intermetallic compounds was confirmed through peeling surface analysis, peeling tests, and tensile testing.
Article
Chemistry, Physical
Zhenhua Fu, Zhenhua Hao, Yusi Che, Yongchun Shu, Jilin He
Summary: A facile method for synthesis of nano-particles attached spherical alloy powders was established based on plasma spheroidization, with in situ synthesized nano-particles attached spherical Ti-6Al-4V powder. The nano-particles are mainly mixtures of AlTi, AlTi3, AlTi2N and TiN with an average size of 85.45 nm, distributed uniformly throughout the surface of spherical Ti-6Al-4V powder. The formation of nano-particles attachment layer is attributed to the vaporization and condensation of raw powder undergoing a steep variation of the temperature.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Characterization & Testing
Mehmet Akif Erden, Fatma Gul Uzun, Mahir Akgun, Hasan Gokce
Summary: In this study, titanium and niobium element powders were added to 316L stainless steel using powder metallurgy technology. The addition of 0.25(Ti-Nb) to 316L stainless steel resulted in the highest yield strength and tensile strengths. However, the mechanical properties decreased with the addition of 0.5Ti, 0.5Nb, and 0.5(Ti-Nb). Additionally, the MQL machining showed better machining output compared to dry machining in terms of surface roughness and cutting temperature, indicating its suitability for sustainable machining processes.
Article
Materials Science, Composites
L. Wang, Z. Q. Liu, S. F. Li, Y. F. Yang, R. D. K. Misra, J. Li, D. Ye, J. Y. Cui, X. M. Gan, Z. J. Tian
Summary: A few-layered Ti3C2 MXene-coated Ti-6Al-4V composite powder was developed with uniform dispersion, high purity, and good thermal stability. The composite showed increased yield strength and thermal conductivity due to the retention and uniform distribution of MXene.
COMPOSITES COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Marie-Luise Sellin, Annett Klinder, Philipp Bergschmidt, Rainer Bader, Anika Jonitz-Heincke
Summary: This study investigated the effects of inhibiting IL-6 receptors on the differentiation of osteoblasts derived from patients with rheumatoid arthritis (RA) and the potential of sarilumab to inhibit wear particle-induced inflammation. The results showed that inhibiting IL-6 receptors had no significant effect on osteoblast differentiation and mineralization, but sarilumab significantly reduced IL-8 secretion.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Physical
S. G. Huang, J. Vleugels, B. Tunca Altintas, J. H. Huang, B. Lauwers, J. Qian
Summary: The study investigated the influence of WC and Ti(C0.7N0.3) content on the microstructure and mechanical properties of NbC solution matrix cermets. Results showed that the variation in WC and Ti(C0.7N0.3) content significantly affected the phase composition, in-situ formed (Nb,W,Ti,Mo)(C,N) solution grain growth, and mechanical properties.れ
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Physical
Jana Markhoff, Jan Wieding, Volker Weissmann, Juliane Pasold, Anika Jonitz-Heincke, Rainer Bader
Article
Engineering, Biomedical
Juliane Pasold, Jana Markhoff, Jenny Tillmann, Martin Krogull, Phillip Pisowocki, Rainer Bader
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Engineering, Biomedical
Jana Markhoff, Carmen Zietz, Christian Fabry, Gerhard Fulda, Rainer Bader
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Materials Science, Multidisciplinary
M. Weinmann, C. Schnitter, M. Stenzel, J. Markhoff, C. Schulze, R. Bader
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
(2018)
Article
Materials Science, Characterization & Testing
Jana Markhoff, Anika Jonitz, Carmen Zietz, Katrin Lochner, Doris Hansmann, Rainer Bader
Article
Chemistry, Physical
Enrico Mick, Jana Markhoff, Aurica Mitrovic, Anika Jonitz, Rainer Bader
Article
Biotechnology & Applied Microbiology
Jana Markhoff, Enrico Mick, Aurica Mitrovic, Juliane Pasold, Katharina Wegner, Rainer Bader
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Medicine, Research & Experimental
Annett Klinder, Jana Markhoff, Anika Jonitz-Heincke, Philipp Sterna, Achim Salamon, Rainer Bader
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Chemistry, Physical
Claudia Matschegewski, Stefanie Kohse, Jana Markhoff, Michael Teske, Katharina Wulf, Niels Grabow, Klaus-Peter Schmitz, Sabine Illner
Summary: This study evaluates the physicochemical and biological properties of nanofiber nonwovens for cardiac implants. It finds that hydrophobic nonwovens are insufficient for rapid cell colonization, but can be improved by plasma treatment. The results highlight the potential of plasma-activated electrospun polymer scaffolds for advanced cardiac implants.
Article
Materials Science, Biomaterials
Stefan Oschatz, Michael Teske, Ulrike Burmeister, Sabine Illner, Volkmar Senz, Hermann Lang, Niels Grabow, Jana Markhoff
Summary: This study investigated the effects of covalently anchored fetuin A on the surface of biodegradable PLLA-co-PEG nonwovens on biomineralization, MG-63 osteoblast cell metabolic activity, biosynthesis of type I collagen propeptide, and inflammatory potential. The results showed that fetuin A functionalization enhanced calcium affinity and biomineralization while maintaining the distinct fiber morphology of the nonwoven. Cell seeding experiments demonstrated that fetuin A functionalized and biomineralized PLLA-co-PEG nonwovens had no negative effects on MG-63 growth. Flow cytometry experiments showed no increase in the inflammatory potential of the material. Overall, this study contributes to the development of artificial scaffolds for guided bone regeneration with potential to enhance osteoinduction and osteogenesis.
BIOMATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Deepanjalee Dutta, Jana Markhoff, Naiana Suter, Kurosch Rezwan, Dorothea Brueggemann
Summary: The modification of nanoporous anodic aluminum oxide (AAO) membranes with biochemical features such as collagen nanofibers or amino groups has shown promising results in promoting cell adhesion for potential wound healing applications. Both 3T3 fibroblasts and HaCaT keratinocytes exhibited comparable metabolic activities on bare and silanized AAO pores until 72 h, but showed reduced proliferation on AAO with collagen nanofibers. The functionalization strategies have high potential to specifically control molecular signaling and cell migration, indicating a promising direction for further development of alumina nanopores for wound healing.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Physical
Jana Markhoff, Martin Krogull, Christian Schulze, Christian Rotsch, Sandra Hunger, Rainer Bader
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)