期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 78, 期 -, 页码 886-891出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.04.104
关键词
Layered double hydroxide; Enrofloxacin; Nanocomposite; Drug delivery system; Magnetic targeting
资金
- Natural Science Foundation of Shanxi Province of China [2013011040-8]
- Training Programs of Innovation and Entrepreneurship for Undergraduates in Shanxi, China [2014431]
- Support Plan for Innovative Research Team of Changzhi University, China
A novel magnetic nanocomposite with enrofloxacin (ENR) intercalated Mg Al layered double hydroxides (LDH) coated on Fe3O4 particles, denoted as Fe3O4@(ENR-LDH), was assembled via a delamination-reassembling process. Fe3O4@(ENR-LDH) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, element chemical analysis, transmission electron microscopy, differential scanning calorimetry, and room temperature magnetic measurements. Results showed the following: C) Fe3O4@(ENR-LDH) consisted of both ENR-LDH nanocrystallite and Fe3O4 phases; C) Fe3O4@(ENR-LDH) presented well-defined core-shell structure with diameter in the range of 15-20 nm; 3 the thermal stability of ENR was enhanced after intercalation; and Fe3O4@(ENR-LDH) exhibited good superparamagnetism. The release kinetics of ENR was investigated in buffer solutions at pH 4.6 and 7.2, and the release process fitted Bhaskar model indicating diffusion-controlled mechanism. In addition, ENR release rate from Fe3O4@(ENR-LDH) was remarkably lower than that from the corresponding physical mixture, showing that Fe3O4@(ENR-LDH) can be considered as a potential magnetic targeting drug delivery-controlled-release system. (C) 2017 Elsevier B.V. All rights reserved.
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