Review
Microbiology
Jian-Long Zhang, Wen-Li Tang, Qing-Rong Huang, You-Zhi Li, Mao-Lian Wei, Lin-Lin Jiang, Chong Liu, Xin Yu, Hong-Wei Zhu, Guo-Zhong Chen, Xing-Xiao Zhang
Summary: Fungi, especially Trichoderma, are essential in drug discovery due to their ability to synthesize diverse specialized metabolites with significant medicinal potential. Recent studies have isolated a large number of secondary metabolites from Trichoderma, showing considerable bioactivities and highlighting their importance in the discovery of new drugs. New strategies for discovering secondary metabolites of Trichoderma in recent years are also discussed.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Seulah Lee, Jae Sik Yu, Seoung Rak Lee, Ki Hyun Kim
Summary: This review summarizes the structures and biological activities of secondary metabolites identified from poisonous mushrooms, providing an overview of the current information on these metabolites with a focus on their chemistry, bioactivity, and biosynthesis.
NATURAL PRODUCT REPORTS
(2022)
Review
Plant Sciences
Gertrud Lohaus
Summary: This review primarily focuses on the chemical composition of phloem sap obtained by aphid stylectomy to facilitate data comparison.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Review
Microbiology
Li-Rong Lei, Lei-Qiang Gong, Meng-Ying Jin, Rui Wang, Ran Liu, Jing Gao, Meng-Dan Liu, Li Huang, Guang-Zhi Wang, Dong Wang, Yun Deng
Summary: This review summarizes the chemical constituents and biological activities of fungi belonging to the genus Talaromyces, providing a reference for the development of high-value natural products and innovative uses of these resources.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Youdan Zhang, Xiaochen Zhang, Jieming Zhang, Shaukat Ali, Jianhui Wu
Summary: This study reveals significant differences in secondary metabolite profiles between an entomopathogenic fungus isolated from the wild and those exposed to spaceflight conditions. The findings support the use of space mutation as a tool for developing fungal strains with increased toxicity/virulence against target insect hosts.
Review
Biochemistry & Molecular Biology
Rupanshee Srivastava, Rajesh Prajapati, Tripti Kanda, Sadhana Yadav, Nidhi Singh, Shivam Yadav, Rajeev Mishra, Neelam Atri
Summary: Microbes, particularly cyanobacteria, produce a variety of secondary metabolites with therapeutic potential. These metabolites could be potential options for COVID-19 treatment due to their demonstrated pharmacological actions against various pathogens. Numerous cyanobacterial metabolites have shown activity against bacteria, fungi, viruses, and tumor cells, making them valuable candidates for the development of medicinal molecules.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Agronomy
Maria Angeles Forner-Giner, Manuel Ballesta-de los Santos, Pablo Melgarejo, Juan Jose Martinez-Nicolas, Amparo Melian-Navarro, Antonio Ruiz-Canales, Alberto Continella, Pilar Legua
Summary: The cultivation of blood oranges for fresh consumption in Europe is increasing due to their excellent organoleptic and nutraceutical properties. Blood oranges have a higher content of bioactive compounds, which confer additional benefits for human health. The main morphological and qualitative parameters were studied, and different varieties of blood oranges were compared in terms of their agronomic parameters and content of primary and secondary metabolites.
Article
Horticulture
Mariana Cecilia Grohar, Barbara Gacnik, Maja Mikulic Petkovsek, Metka Hudina, Robert Veberic
Summary: The study investigated the caffeine content and phenolic profile of different types of teas and coffees with two successive extractions. Green tea showed high flavanol content in the second extraction, while mate tea's phenolic acid content increased. Black tea had the highest caffeine content in both extractions, and water was the most effective solvent in most cases for extracting these compounds.
Review
Chemistry, Medicinal
Marcelo D. Catarino, Rita Silva-Reis, Amina Chouh, Sonia Silva, Susana S. Braga, Artur M. S. Silva, Susana M. Cardoso
Summary: This article provides an overview of Sargassum seaweeds, one of the largest and most diverse genus of brown seaweeds, comprising around 400 taxonomically accepted species. Many species of this genus have long been used in human culture for food, feed, and folk medicine. Besides their high nutritional value, these seaweeds are also rich in natural antioxidant compounds, such as polyphenols, carotenoids, meroterpenoids, and phytosterols. These compounds have important applications in various fields, including agriculture, food, and health, and can be used for product preservation, cosmetics, and crop production improvement.
Article
Chemistry, Multidisciplinary
Pavithira Suresh, Subramaniyan Prasanna Kumari, Singarajanahalli Mundarinti Krishna Reddy, Savarimuthu Philip Anthony, Subbiah Thamotharan, Subramaniapillai Selva Ganesan
Summary: Regioselective vicinal difunctionalization of diverse alkene derivatives was successfully achieved using easily accessible carboxylic acids. The reaction involved molecular oxygen in the air, resulting in the formation of peroxygenated products in good yields. The reactions were conducted at room temperature, and hydroacylated products were obtained by utilizing Csp(2) hybridized carbonyl radicals.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Parisa Abbasi-Parizad, Patrizia De Nisi, Tommy Pepe Sciarria, Alessio Scarafoni, Pietro Squillace, Fabrizio Adani, Barbara Scaglia
Summary: This study tested Spontaneous Fermentation as a treatment to modify polyphenols in food industry by-products, resulting in increased extractable amounts and antioxidant activity, as well as a higher concentration of specific bioactive polyphenols through cofermentation.
Review
Pharmacology & Pharmacy
Rui Wang, Yong Fen Qi, Chun Hua Ding, Da Zhang
Summary: This review examines the recent progress in understanding the occurrence and regulation of atrial fibrosis, as well as the role of sulfur containing amino acids and their metabolites in this process. The findings provide new insights into the mechanisms of atrial fibrosis and potential targets for therapeutic interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yu Duan, Xiaowen Shang, Guodong Liu, Zhongwei Zou, Xujun Zhu, Yuanchun Ma, Fang Li, Wanping Fang
Summary: The study found that there were significant changes in the metabolic of secondary metabolites in tea plants when intercropped with soybean, especially during the profuse flowering stage of soybean. Through the intercropping system, tea plants showed higher chlorophyll photosynthetic parameters and photosynthetic activity. These results provide a basis for reducing the application of nitrogen fertilizer and improving the ecosystem in tea plantations.
Review
Environmental Sciences
Harshida A. Gamit, Hetvi Naik, Komal A. Chandarana, Sapna Chandwani, Natarajan Amaresan
Summary: Climate change is a natural disaster that leads to fluctuations in the ecosystem and an increase in temperature and UV radiation on the Earth's surface. Greenhouse gases, such as chlorofluorocarbons, methane, nitrogen oxide, and carbon dioxide, hinder sustainable agriculture. Using microorganisms to overcome environmental stress and enhance plant growth is a viable option. Methylobacterium, a pink-pigmented facultative methylotroph, produces secondary metabolites that improve plant metabolism and promote growth under stress conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Chuan Zhong, Jiawen Huang, Dong Jiang, Yingxin Zhong, Xiao Wang, Jian Cai, Wei Chen, Qin Zhou
Summary: Nitrogen application improves wheat yield and protein content, but also affects the nutritional quality. Metabolomics analysis revealed that amino acids, nucleic acids, phytohormones, glycolytic processes, and metabolite spatial variation are crucial factors for protein content in wheat grains. Nitrogen and genotypes interactively regulate amino acids, derivatives, lipids, flavonoids, and their spatial variation, which contribute to the nutritional quality of grains. Excessive nitrogen application may hinder the accumulation of beneficial bioactive substances in the inner layer, resulting in poor nutritional quality.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Microbiology
Siyuan Feng, Yan Liu, Wanfei Liang, Mohamed Abd El-Gawad El-Sayed Ahmed, Zihan Zhao, Cong Shen, Adam P. Roberts, Lujie Liang, Liya Liao, Zhijuan Zhong, Zhaowang Guo, Yongqiang Yang, Xin Wen, Hongtao Chen, Guo-bao Tian
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
Minmin Lin, Yongqiang Yang, Yanxian Yang, Guanping Chen, Ruowen He, Yiping Wu, Lan-Lan Zhong, Mohamed Abd El-Gawad El-Sayed Ahmed, Siyuan Feng, Cong Shen, Xin Wen, Jin Huang, Hongyu Li, Xiaobin Zheng, Guo-Bao Tian
INFECTION AND DRUG RESISTANCE
(2020)
Article
Food Science & Technology
Mingxing Huang, Hongtao Chen, Chunna Li, Yan Liu, Chongjie Gan, Mohamed Abd El-Gawad El-Sayed Ahmed, Ruihong Liu, Cong Shen, Ruoxuan Zhong, Guo-Bao Tian, Xi Huang, Jinyu Xia
FOODBORNE PATHOGENS AND DISEASE
(2020)
Article
Microbiology
Ruowen He, Yongqiang Yang, Yiping Wu, Lan-Lan Zhong, Yanxian Yang, Guanping Chen, Mingyang Qin, Xiaoxue Liang, Mohamed Abd El-Gawad El-Sayed Ahmed, Minmin Lin, Bin Yan, Yong Xia, Min Dai, Hongtao Chen, Guo-Bao Tian
Summary: The study identified two MDR Klebsiella pneumoniae isolates carrying mcr-1 from patients with urinary tract infections, and one MDR Klebsiella quasipneumoniae isolate carrying tmexCD1-toprJ1 from a patient with bloodstream infection. The addition of an efflux pump inhibitor significantly reduced tigecycline resistance in these isolates. Additionally, a plasmid carrying tmexCD1-toprJ1 was successfully transferred via conjugation from K. quasipneumoniae to Escherichia coli J53 for further analysis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Cong Shen, Furong Ma, Suiyan Deng, Lan-Lan Zhong, Mohamed Abd El-Gawad El-Sayed Ahmed, Guili Zhang, Bin Yan, Min Dai, Fan Yang, Yong Xia, Guo-Bao Tian
Summary: The prevalence of mcr-1-positive Salmonella from different sources was low, with horizontal transfer of IncHI2-pST3 plasmid being the main mode of transmission. Clonal transmission was not the main reason for the expansion of mcr-1-positive Salmonella.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Immunology
Siyuan Feng, Zhongsi Hong, Guoliang Zhang, Jiachen Li, Guo-Bao Tian, Haibo Zhou, Xi Huang
Summary: CRISPR interference was used to study the ppe31 gene in Mycobacterium marinum and Mycobacterium tuberculosis, revealing its role in resistance to acid medium, inflammatory mediator expression in infected macrophages, and host cell death. Deletion of ppe31 from both strains increased sensitivity to acid medium and decreased cell death in macrophages, indicating PPE31 as a virulence factor modulating innate immune responses to mycobacterial infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Mohamed Abd El-Gawad El-Sayed Ahmed, Yanxian Yang, Yongqiang Yang, Bin Yan, Guanping Chen, Reem Mostafa Hassan, Lan-Lan Zhong, Yuan Chen, Adam P. Roberts, Yiping Wu, Ruowen He, Xiaoxue Liang, Mingyang Qin, Min Dai, Liyan Zhang, Hongyu Li, Fan Yang, Lingqing Xu, Guo-Bao Tian
Summary: The study presents the genetic basis and plasmid analysis of carbapenem-resistant hypervirulent K. pneumoniae (CR-HvKP) in Egyptian hospitals. The main findings include the identification of different sequence types of CRKP isolates, the presence of high-risk clone ST11 KL47 serotype, and the coexistence of carbapenemase-encoding and virulence plasmids in a CR-HvKP strain. This research aims to alert clinicians to the hypervirulence of CRKP isolates and the evolving virulence and multidrug resistance in K. pneumoniae.
Article
Biotechnology & Applied Microbiology
Zhien He, Yongqiang Yang, Wei Li, Xiaoling Ma, Changfeng Zhang, Jingxiang Zhang, Baolin Sun, Tao Ding, Guo-Bao Tian
Summary: This study provides important information on Enterobacteriaceae bacteria carrying mcr-like genes and serves as a reference for the study of mcr-1 transmission in China and globally.
Article
Ecology
Zhuoxing Wu, Xiujuan Cai, Xin Zhang, Yao Liu, Guo-bao Tian, Jian-Rong Yang, Xiaoshu Chen
Summary: This study found that the phenotypic effects of genetic mutations are related to gene expression levels, with at least 42% of single-nucleotide mutations showing fitness effects dependent on gene expression levels and influenced by stochastic molecular errors.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Microbiology
Lujie Liang, Daixi Lin, Yishen Chen, Jiachen Li, Wanfei Liang, Hui Zhao, Wenji Luo, Guo-bao Tian, Siyuan Feng
Summary: The rapid emergence of multidrug-resistant/extensively drug-resistant tuberculosis (TB) poses a significant threat to global public health. Bioenergetics has become a new approach for anti-TB drug discovery, focusing on the link between bacterial ATP levels and drug efficacy. This study developed a novel ATP biosensor, ATPser, which accurately detected intracellular ATP fluctuations in mycobacteria. The results showed a close correlation between ATP fluctuations and drug efficacy, and drug combinations accelerated ATP perturbation and cell death. ATPser enables real-time measurement of ATP at the single-cell level, providing insights for novel treatment strategies.
Review
Immunology
Ji Zeng, Hao Wang, Min Dong, Guo-Bao Tian
Summary: This review provides insights into the C. difficile infection and the assembly of the spore coat, focusing on signal processing, transcriptional regulation, and the poorly understood process of coat assembly.
EMERGING MICROBES & INFECTIONS
(2022)
Letter
Infectious Diseases
Jiachen Li, Siyuan Feng, Yuhui Chen, Meiling Yu, Wenjing Wei, Guo-Bao Tian
Article
Engineering, Biomedical
Zihan Zhao, Shu'an Wen, Ningning Song, Lixiang Wang, Yuan Zhou, Xue Deng, Changbu Wu, Guili Zhang, Jun Chen, Guo-Bao Tian, Minmin Liang, Lan-Lan Zhong
Summary: This study demonstrates that combining antimicrobial nanozymes with L-arginine can effectively treat difficult-to-treat Gram-negative pathogen infections. The combination treatment enhances bacterial membrane permeability and promotes ROS production, leading to the killing of pathogens.
ADVANCED HEALTHCARE MATERIALS
(2023)
Letter
Immunology
Cong Shen, Lan-Lan Zhong, Zhijuan Zhong, Yohei Doi, Jianzhong Shen, Yang Wang, Furong Ma, Mohamed Abd El-Gawad El-Sayed Ahmed, Guili Zhang, Yong Xia, Cha Chen, Guo-Bao Tian
Summary: China banned the use of colistin in livestock fodders in response to the spread of the colistin resistance gene mcr-1. A time-series analysis of inpatient colonization data from 2011-2019 accurately revealed fluctuations in mcr-1 among inpatients in response to the ban.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Yongqiang Yang, Yanxian Yang, Guanping Chen, Minmin Lin, Yuan Chen, Ruowen He, Klibs N. Galvao, Mohamed Abd El-Gawad El-Sayed Ahmed, Adam P. Roberts, Yiping Wu, Lan-Lan Zhong, Xiaoxue Liang, Mingyang Qin, Xin Ding, Wenbin Deng, Songyin Huang, Hong-Yu Li, Min Dai, Ding-Qiang Chen, Liyan Zhang, Kang Liao, Yong Xia, Guo-Bao Tian
Summary: This study investigated 425 isolates of Klebsiella pneumoniae to clarify the characteristics of carbapenemase-encoding and virulent plasmids. The findings revealed the multifactorial impact of KPC-2 plasmids on the bacteria, potentially associated with nosocomial dissemination of multidrug-resistant isolates.
EMERGING MICROBES & INFECTIONS
(2021)