Fast and simultaneous determination of H-1-H-1 and H-1-F-19 scalar couplings in complex spin systems: Application of PSYCHE homonuclear broadband decoupling

The present manuscript focuses on fast and simultaneous determination of H-1-H-1 and H-1-F-19 scalar couplings in fluorinated complex steroid molecules. Incorporation of broadband PSYCHE homonuclear decoupling in the indirect dimension of zero-quantum filtered diagonal experiments (F1-PSYCHE-DIAG) suppresses H-1-H-1 scalar couplings; however, it retains H-1-F-19 scalar couplings (along F1 dimension) for the F-19 coupled protons while preserving the pure-shift nature for H-1 resonances uncoupled to F-19. In such cases, along the direct dimensions, H-1-H-1 scalar coupling multiplets deconvolute and they appear as duplicated multiplets for the F-19 coupled protons, which facilitates unambiguous discrimination of F-19 coupled H-1 chemical sites from the others. Further, as an added advantage, data acquisition has been accelerated by invoking the known ideas of spectral aliasing in the F1-PSYCHE-DIAG scheme and experiments demand only similar to 10min of spectrometer times.