Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Lin, Yanyu Li, Jian Wang, Likun Cao, Yajing Liu, Jianing Pang, Jing An, Zhengyu Jin, Yining Wang
Summary: This study evaluates the feasibility and accuracy of a free-breathing cardiac cine imaging technique for biventricular assessment. The results suggest that this technique achieves comparable or even better image quality and quantitative analysis compared to existing techniques.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cong Sun, Kiarash Ghassaban, Jiaguang Song, Yufan Chen, Chao Zhang, Feifei Qu, Jinxia Zhu, Guangbin Wang, E. Mark Haacke
Summary: This study used quantitative susceptibility mapping (QSM) to evaluate calcium deposition in the fetal spine. The results showed that the magnetic susceptibility of the fetal spine decreased linearly as gestational age advanced. QSM is a reliable technique for evaluating calcium deposition and bone mineral density in the fetal spine.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tilman Emrich, Veronica Bordonaro, U. Joseph Schoepf, Aniela Petrescu, Gabrielle Young, Moritz Halfmann, Theresia Schoeler, Josua Decker, Ibukun Abidoye, Anna Lena Emrich, Karl-Friedrich Kreitner, Kai Helge Schmidt, Akos Varga-Szemes, Aurelio Secinaro
Summary: The study aimed to test the feasibility of T2 mapping for detecting left-to-right shunts. Results indicated that the T2 ratio can serve as an imaging biomarker capable of detecting or ruling out left-to-right shunts.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Computer Science, Interdisciplinary Applications
Seung-Kyun Lee, Sukhoon Oh, Hyeong-Seop Kim, Byung-Pan Song
Summary: A method to measure the radio-frequency vector magnetic field inside an object using MRI was presented in this study. By repeating B-1(+) mapping on the same object and coil at multiple orientations, all Cartesian components of the RF field can be determined accurately. Results showed favorable comparison between measured RF vector field maps and numerical simulation, demonstrating the effectiveness of the proposed method.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Food Science & Technology
Kathryn E. Anderssen, Shaheen Syed, Svein Kristian Stormo
Summary: Magnetic resonance imaging (MRI) was utilized to assess tissue damage caused by freezing in fish, revealing that lower freezing temperatures generally resulted in less damage. A trained neural network accurately identified damaged tissue regions, with a high correlation between the percentage of damaged tissue classified and liquid loss.
Article
Cardiac & Cardiovascular Systems
Pengfei Yue, Ziqian Xu, Ke Wan, Yinxi Tan, Yuanwei Xu, Xiaotong Xie, David Mui, Cheng Yi, Yuchi Han, Yucheng Chen
Summary: This study explores the quantitative characteristics and diagnostic performance of native T1, T2, and extracellular volume (ECV) values of cardiac tumors and left ventricular myocardium. The study finds that the native T1 values of primary malignant cardiac tumors are significantly higher compared to benign tumors and normal controls, which may serve as a new imaging marker for primary malignant cardiac tumors.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Sruti Rao, Stephanie Y. Tseng, Amol Pednekar, Saira Siddiqui, Murat Kocaoglu, Munes Fares, Sean M. Lang, Shelby Kutty, Adam B. Christopher, Laura J. Olivieri, Michael D. Taylor, Tarek Alsaied
Summary: Parametric mapping is a pixel-wise mapping of magnetic relaxation parameters, which allows for quantification of myocardial tissue-specific magnetic relaxation. It has expanded the diagnostic potential of cardiac magnetic resonance and is important for the diagnosis of nonfocal diseases, longitudinal disease monitoring, and risk stratification.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philip A. Corrado, Andrew L. Wentland, Jitka Starekova, Archana Dhyani, Kara N. Goss, Oliver Wieben
Summary: This study evaluates the use of automatic ventricular segmentation based on deep learning in 4D flow MRI post-processing. The results show that the automated segmentation method provides hemodynamic measurements that differ less than the variation between manual observers, thus reducing post-processing time and mitigating interobserver variability.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Bottcher, Roberto Lorbeer, Sophia Stocklein, Ebba Beller, Cajetan I. Lang, Marc-Andre Weber, Felix G. Meinel
Summary: The global and regional reproducibility of native T1 and T2 mapping in cardiac MRI was investigated in healthy volunteers, revealing good to excellent reproducibility with significant regional differences, providing valuable insights for the diagnosis and risk stratification of cardiac diseases.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Secchi, Marco Ali, Caterina B. Monti, Andreas Greiser, Francesca R. Pluchinotta, Mario Carminati, Francesco Sardanelli
Summary: This study evaluated the feasibility of systolic RV T1 mapping and its association with congenital heart disease. Results showed that systolic RV nT1 demonstrated high reproducibility and a negative correlation with RV ejection fraction, potentially reflecting adaptation of the RV myocardium to pulmonary valve/conduit (dys)-function.
Article
Multidisciplinary Sciences
K. S. Cujia, K. Herb, J. Zopes, J. M. Abendroth, C. L. Degen
Summary: The study extends nuclear magnetic resonance imaging to large nuclear spin clusters by combining weak quantum measurements, phase encoding, and simulated annealing. This method allows for the simultaneous detection of three-dimensional positions from multiple nuclei, with spatial selectivity and successful imaging of clusters containing multiple nuclear spins at room temperature.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Bard A. Bendiksen, Gary McGinley, Ivar Sjaastad, Lili Zhang, Emil K. S. Espe
Summary: Myocardial velocities play a crucial role in diagnosing cardiac diseases, particularly left ventricular diastolic dysfunction. Tissue Phase Mapping (TPM) MRI allows for precise sampling of the myocardium's velocity field, and a post-processing framework using linear or cubic B-splines can generate a smooth and continuous representation. The framework was evaluated using synthetic data with added noise, showing reduced agreement limits and lower end point errors, with Linear B-splines outperforming Cubic B-splines and appearing more suitable for TPM data.
Article
Chemistry, Multidisciplinary
Rebecca R. Baker, Christopher Payne, Yichao Yu, Matin Mohseni, John J. Connell, Fangyu Lin, Ian F. Harrison, Paul Southern, Umesh S. Rudrapatna, Daniel J. Stuckey, Tammy L. Kalber, Bernard Siow, Lewis Thorne, Shonit Punwani, Derek K. Jones, Mark Emberton, Quentin A. Pankhurst, Mark F. Lythgoe
Summary: Magnetic resonance navigation is an emergent technique that allows for remote control of magnetically labeled therapies and devices using an MRI system. The MINIMA technique, a novel MRI-guided ablation technique, has the potential to avoid traditional toxicities and offers precise control over the ablation volume.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shanmei Zeng, Hui Ma, Dingxiang Xie, Yingqian Huang, Mengzhu Wang, Wenting Zeng, Nengjin Zhu, Zuliwei Ma, Zhiyun Yang, Jianping Chu, Jing Zhao
Summary: This study comprehensively evaluated gliomas using quantitative susceptibility mapping (QSM). The magnetic susceptibility of the tumor parenchyma was found to be associated with other MRI parameters and may be affected by tumor cell proliferation. However, it had limited value in identifying IDH mutation status.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Safwat Aly, Mike Seed, Shi-Joon Yoo, Christopher Lam, Lars Grosse-Wortmann
Summary: The study found that children and adolescents with Ebstein's anomaly experience diffuse myocardial fibrosis, which is associated with O-2 saturation. Global circumferential strain is correlated with native T1 values, but not ejection fraction.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Clinical Neurology
Ting Du, Humberto Mestre, Benjamin T. Kress, Guojun Liu, Amanda M. Sweeney, Andrew J. Samson, Martin Kaag Rasmussen, Kristian Nygaard Mortensen, Peter A. R. Bork, Weiguo Peng, Genaro E. Olveda, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal Mehta, Hajime Hirase, Yuki Mori, Maiken Nedergaard
Summary: Cerebral edema develops after anoxic brain injury and is associated with the availability of cerebrospinal fluid (CSF). An increase in CSF volume worsens the severity of edema. Edema primarily occurs in brain regions bordering CSF compartments. Anoxic brain tissue possesses a high intrinsic osmotic potential, which may contribute to the beneficial effect of therapeutic hypothermia.
Article
Veterinary Sciences
Camilla Andersen, John F. Griffin, Stine Jacobsen, Stine Ostergaard, Marie Walters, Yuki Mori, Casper Lindegaard
Summary: This study validates ultrasonography as a tool for measuring cartilage thickness in the carpus of horses. The results show that a 15 MHz ultrasound transducer has good agreement with MRI and histological assessments, and acceptable repeatability when used for assessing cartilage thickness in the radiocarpal joint. On the other hand, a 9 MHz ultrasound transducer showed poorer agreement and suboptimal repeatability. A 15 MHz ultrasound transducer is recommended for detecting changes in cartilage thickness or monitoring development over time.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Multidisciplinary Sciences
Nicole L. Henriksen, Karina S. Asmussen, Xiaoyu Pan, Ping-Ping Jiang, Yuki Mori, Line Christiansen, Richard R. Sprenger, Christer S. Ejsing, Stanislava Pankratova, Thomas Thymann
Summary: This study found that the fat source in diet can influence the plasma and hippocampal lipidome in three-day-old piglets, but is unable to improve brain structural and functional impairments induced by IUGR.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
Camilla Andersen, Kristina Uvebrant, Yuki Mori, Stacie Aarsvold, Stine Jacobsen, Lise Charlotte Berg, Evy Lundgren-Akerlund, Casper Lindegaard
Summary: This study demonstrated that human adipose tissue derived integrin alpha 10 beta 1-selected MSCs (integrin alpha 10-MSCs) can migrate specifically to cartilage defects in a rabbit model and differentiate into chondrocytes to promote cartilage repair.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Neurosciences
Eva Baerends, Katia Soud, Jonas Folke, Anna-Kathrine Pedersen, Simon Henmar, Lisa Konrad, Matthew D. Lycas, Yuki Mori, Bente Pakkenberg, David P. D. Woldbye, Oksana Dmytriyeva, Stanislava Pankratova
Summary: This study evaluated early behavioral, anatomical, and molecular changes in rats following injections of human Aβ oligomers. Social memory impairment and changes in brain structure were observed, indicating possible neuroinflammatory responses and synaptopathy associated with Aβ oligomer injections.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Multidisciplinary Sciences
Tomas Bohr, Poul G. Hjorth, Sebastian C. Holst, Sabina Hrabetova, Vesa Kiviniemi, Tuomas Lilius, Iben Lundgaard, Kent-Andre Mardal, Erik A. Martens, Yuki Mori, U. Valentin Nagerl, Charles Nicholson, Allen Tannenbaum, John H. Thomas, Jeffrey Tithof, Helene Benveniste, Jeffrey J. Iliff, Douglas H. Kelley, Maiken Nedergaard
Summary: This article reviews theoretical and numerical models of the glymphatic system, which plays a role in solute transport and has clinical applications in drug delivery, stroke, and neurodegenerative disorders. The authors categorize existing models based on their anatomical functions and highlight the need for future work, including new models and experiments to improve our understanding of the system.
Article
Multidisciplinary Sciences
Kjeld Mollgard, Felix R. M. Beinlich, Peter Kusk, Leo M. Miyakoshi, Christine Delle, Virginia Pla, Natalie L. Hauglund, Tina Esmail, Martin K. Rasmussen, Ryszard S. Gomolka, Yuki Mori, Maiken Nedergaard
Summary: The central nervous system is lined by four meningeal layers, including a newly discovered layer called subarachnoid lymphatic-like membrane (SLYM), which resembles mesothelial membrane found in peripheral organs. SLYM encloses blood vessels and contains immune cells. It allows direct exchange of small solutes between cerebrospinal fluid and venous blood, similar to arachnoid granulations in mice. The functional characterization of SLYM provides important insights into brain immune barriers and fluid transport.
Article
Endocrinology & Metabolism
Bjorn Sigurdsson, Natalie L. Hauglund, Tuomas O. Lilius, Frida L-H Mogensen, Kristian N. Mortensen, Natalie Beschorner, Laura Klinger, Simone L. Baerentzen, Marko P. Rosenholm, Vladimir Shalgunov, Matthias Herth, Yuki Mori, Maiken Nedergaard
Summary: SPECT/CT imaging is a promising tool for assessing the glymphatic system, as it overcomes the limitations of other imaging modalities such as fluorescence microscopy, cortical imaging, and MRI. The study shows that SPECT imaging can accurately visualize the flow of cerebrospinal fluid and identify brain state-dependent differences in glymphatic function. Compared to MRI, SPECT imaging has higher sensitivity and is capable of detecting a wider range of tracer concentrations, making it a valuable alternative for glymphatic research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N. T. P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J. P. van Osch
Summary: Neurofluids refer to all fluids in the brain and spine, including blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists have identified various fluid environments that interact harmoniously to support optimal brain function. Animal studies have been crucial in understanding the dynamics of neurofluids, while human studies are limited due to the lack of noninvasive imaging techniques. The future development of noninvasive MRI techniques holds promise in imaging neurofluid dynamics and identifying pathological processes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Christine Delle, Neza Cankar, Christian Digebjerg Holgersson, Helle Hvorup Knudsen, Elise Schioler Nielsen, Celia Kjaerby, Yuki Mori, Maiken Nedergaard, Pia Weikop
Summary: Obesity is associated with increased risk of cognitive decline, and this study investigated the glymphatic transport in mice with long-term obesity induced by high-fat diet. The results showed that although the obese mice developed hypertension, elevated heart rate, neuroinflammation, and gliosis, the glymphatic inflow was globally unaffected except in the hypothalamus. It suggests that long-term high-fat diet induced metabolic alteration and neuroinflammation in the hypothalamus, leading to enhanced glymphatic clearance in this specific brain region.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Ryszard Stefan Gomolka, Lauren M. Hablitz, Humberto Mestre, Michael Giannetto, Ting Du, Natalie Linea Hauglund, Lulu Xie, Weiguo Peng, Paula Melero Martinez, Maiken Nedergaard, Yuki Mori, Saad Jbabdi
Summary: The glymphatic system is a fluid transport network that plays a crucial role in clearing interstitial solutes from the brain. The expression of AQP4 water channels facilitates cerebrospinal fluid transport and its genetic deletion results in abnormalities in brain structure and water transport. This study used advanced imaging techniques to explore the disruption of glymphatic function in AQP4 KO mice.
Article
Neurosciences
Line I. Christiansen, Gemma C. Ventura, Bo Holmqvist, Karoline Aasmul-Olsen, Sandy E. H. Lindholm, Matthew D. Lycas, Yuki Mori, Jan Bojsen-Moller Secher, Douglas G. Burrin, Thomas Thymann, Per T. Sangild, Stanislava Pankratova
Summary: Preterm infants are at increased risk of impaired neurodevelopment, which may be related to reduced levels of insulin-like growth factor 1 (IGF-1) after birth. This study used preterm pigs as a model to investigate the effects of postnatal IGF-1 supplementation on brain development. The results showed that IGF-1 treatment improved motor function and enhanced GABAergic maturation in the caudate nucleus, but reduced myelination in certain brain regions. These findings suggest that supplemental IGF-1 may support postnatal brain development in preterm infants.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yuka Kimura, Shunsuke Nakazawa, Kantaro Nishigori, Yuki Mori, Junji Ichihara, Yoshichika Yoshioka
Summary: This study investigated the role of the dopamine D1 receptor in the rat brain using pharmacological functional MRI. The results showed that D1 agonists increased the blood oxygenation level-dependent (BOLD) signal in certain brain regions, while D1 antagonists reduced it. These findings provide insights into the neurophysiological function of dopamine receptors.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Cell Biology
Barbara K. Mathiesen, Leo M. Miyakoshi, Christopher R. Cederroth, Evangelia Tserga, Corstiaen Versteegh, Peter A. R. Bork, Natalie L. Hauglund, Ryszard Stefan Gomolka, Yuki Mori, Niklas K. Edvall, Stephanie Rouse, Kjeld Mollgard, Jeffrey R. Holt, Maiken Nedergaard, Barbara Canlon
Summary: Gene therapy through cerebrospinal fluid may restore hearing in adult mice and potentially in humans, as the cerebrospinal fluid can reach the inner ear through the cochlear aqueduct. This provides an accessible route for gene delivery and a promising step towards restoring hearing in adults.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, Rocio Garcia Vazquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schafer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvanen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti, Matthias Manfred Herth
Summary: Pretargeting is a powerful nuclear imaging strategy to enhance imaging contrast and reduce radiation burden for nanomedicines. In this study, we developed Tz imaging agents that can bind in vivo to targets beyond the blood-brain barrier (BBB). The pretargeting beyond the BBB allows imaging of currently non-imageable brain targets, enabling early diagnosis and personalized treatment monitoring.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Slimane Tounekti, Mahdi Alizadeh, Devon Middleton, James S. Harrop, Bassem Hiba, Laura Krisa, Choukri Mekkaoui, Feroze B. Mohamed
Summary: This study proposes and demonstrates a new method combining reduced field-of-view strategy with phase segmented EPI to address geometric distortion in post-operative DTI scans of patients with metal implants. The results show that the new method outperforms traditional techniques in reducing distortion.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Minosse, Eliseo Picchi, Valentina Ferrazzoli, Noemi Pucci, Valerio Da Ros, Raffaella Giocondo, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Summary: The aim of this study was to investigate the variation of DCE-MRI-derived kinetic parameters in brain tumors as a function of acquisition time. The results showed that K-ep and V-e were time-dependent and required longer scan times to obtain reliable parameter values, while K-trans was time-independent and remained the same in all acquisition times, making it a reliable parameter for short acquisition times.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingmin Guan, Xinheng Zhang, Hsin-Jung Yang, Rohan Dharmakumar
Summary: This study aims to investigate why DIR-prepared dark-blood T2* weighted images have lower SNR, CNR, and diagnostic accuracy for intramyocardial hemorrhage (IMH) detection compared to non-DIR-prepared bright-blood T2* images. Through phantom and animal studies, it was confirmed that the signal loss on DIR-prepared T2* images mainly originates from spin-relaxation during the DIR preparation. Therefore, when used for IMH detection, extra attention should be paid to the SNR of DIR-prepared dark-blood T2* imaging protocols.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Beatriz Laureano, Hassna Irzan, Helen OReilly, Sebastian Ourselin, Neil Marlow, Andrew Melbourne
Summary: Prematurity and preterm stressors have significant effects on the development of infants, especially at earlier gestations. While neonatal care advances have reduced preterm mortality rates, disability rates continue to grow in middle-income settings. Imaging the preterm brain using MR technology has improved our understanding of its development and the affected regions and networks. This research aims to support interventions, improve neurodevelopment, and provide accurate prognoses for preterm infants. This study focuses on the fully developed brain of extremely preterm subjects and examines myelin-related biomarkers to assess long-term effects. The findings suggest altered connectivity and cognitive outcomes in the adult preterm brain.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julian Rauch, Frederik B. Laun, Peter Bachert, Mark E. Ladd, Tristan A. Kuder
Summary: This study presents a method for reducing concomitant field effects in double diffusion encoding (DDE) sequences by adding oscillating gradient pulses. The modified sequences successfully reduced accumulated concomitant phase without significant changes in the original sequence characteristics. The proposed method led to an increase in signal-to-noise ratio (SNR) for phantom and in vivo experiments, supported by simulations.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marlon Bran Lorenzana, Shekhar S. Chandra, Feng Liu
Summary: Sparse reconstruction is important in MRI for reducing acquisition time and improving spatial-temporal resolution. This paper introduces two decoupling techniques for explicit 1D regularization and a combined 1D + 2D reconstruction technique that improves image quality.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yifan Gou, W. Christopher Golden, Zixuan Lin, Jennifer Shepard, Aylin Tekes, Zhiyi Hu, Xin Li, Kumiko Oishi, Marilyn Albert, Hanzhang Lu, Peiying Liu, Dengrong Jiang
Summary: ARTS algorithm improves the reliability of Y-v estimation in noncompliant subjects, enhancing the utility of Y-v as a biomarker for brain diseases.
MAGNETIC RESONANCE IMAGING
(2024)
