Review
Pharmacology & Pharmacy
Lia Farahi, Satyesh K. Sinha, Aldons J. Lusis
Summary: Atherosclerosis is a chronic inflammatory disease that involves the recruitment and differentiation of monocytes into macrophages in response to inflammatory insults. Macrophages play critical roles in tissue damage, wound healing, and regression of atherosclerotic lesions, and their phenotypes are influenced by various stimuli. Recent advances in single-cell sequencing have revealed the heterogeneity of macrophages in lesions, shedding light on potential macrophage-based therapies for atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Bingbing Lin, Juan Yang, Yuwei Song, Guohui Dang, Juan Feng
Summary: Atherosclerosis serves as the common pathological foundation for myocardial infarction and ischemic stroke. Exosomes released by different cell types play a crucial role in cell-to-cell communication, affecting the function of target cells. The potential applications of exosomes in clinical diagnosis and treatment are significant.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dmitry A. Kashirskikh, Vasily N. Sukhorukov, Vladislav Kalmykov, Andrey V. Omelchenko, Alexander N. Orekhov
Summary: Atherosclerosis is a major cause of serious cardiovascular disorders, and its pathogenesis involves multiple processes. Reverse transport of cholesterol is a mechanism that plays a protective role against atherosclerosis. Disordered cholesterol metabolism can result in dyslipidemia and early atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Atif Zafar, Hang Pong Ng, Rachel Diamond-Zaluski, Gun-Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar
Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.
Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Article
Cell Biology
Kind-Leng Tong, Ke-En Tan, Yat-Yuen Lim, Xin-Yi Tien, Pooi-Fong Wong
Summary: This review discusses the role of circular RNAs (circRNAs) in the pathogenesis of atherosclerosis, focusing on their interactions with microRNAs (miRNAs) and messenger RNAs (mRNAs). The mechanisms and clinical relevance of circRNAs in atherogenesis are systematically analyzed, providing a comprehensive overview of the knowledge gap in this field.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Immunology
Christina Maeder, Thimoteus Speer, Angela Wirth, Jes-Niels Boeckel, Sameen Fatima, Khurrum Shahzad, Marc Freichel, Ulrich Laufs, Susanne Gaul
Summary: The presence of IL-1α on the cell surface of circulating leukocytes is crucial for the development of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Isabelle Coornaert, Cedric H. G. Neutel, Yves Dondelinger, Tom Delanghe, Mathieu J. M. Bertrand, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: The study investigates the effects of RIPK1 kinase activity on atherosclerosis and suggests that inhibiting RIPK1 kinase activity accelerates the progression of atherosclerosis.
Review
Cell Biology
Yegor E. Yegorov, Anastasia V. Poznyak, Nikita G. Nikiforov, Antonina V. Starodubova, Alexander N. Orekhov
Summary: The shortening of telomeres is associated with cell senescence and the development of atherosclerosis, while the expression of telomerase can elongate telomeres and resist senescence. Atherosclerosis is believed to be linked to local cell senescence, with wall shear stress in the arteries possibly playing a role.
Article
Chemistry, Multidisciplinary
Hui Yang, Chang Liu, Yanjun Wu, Meng Yuan, Jiarun Huang, Yuhan Xia, Qinjie Ling, Peter R. Hoffmann, Zhi Huang, Tianfeng Chen
Summary: This study develops a translational nanosystem using D-mannose modified selenium nanoparticles to inhibit the occurrence and development of atherosclerosis, and demonstrates strong anti-inflammatory effects.
Article
Cardiac & Cardiovascular Systems
Katrin Nitz, Michael Lacy, Mariaelvy Bianchini, Kanin Wichapong, Irem Avcilar Kuecuekgoeze, Cecilia A. Bonfiglio, Roberta Migheli, Yuting Wu, Carina Burger, Yuanfang Li, Ignasi Forne, Constantin Ammar, Aleksandar Janjic, Sarajo Mohanta, Johan Duchene, Johan W. M. Heemskerk, Remco T. A. Megens, Edzard Schwedhelm, Stephan Huveneers, Craig A. Lygate, Donato Santovito, Ralf Zimmer, Axel Imhof, Christian Weber, Esther Lutgens, Dorothee Atzler
Summary: Amino acid homoarginine reduces atherosclerosis by modulating the T-cell cytoskeleton and inhibiting T-cell functions. This finding provides a molecular explanation for the beneficial effects of homoarginine in atherosclerotic cardiovascular disease.
CIRCULATION RESEARCH
(2022)
Article
Cell Biology
Guizhen Zhao, Haocheng Lu, Yuhao Liu, Yang Zhao, Tianqing Zhu, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Summary: The study investigated the transcriptomic changes in endothelial cells (ECs) in diabetic atherosclerosis using single-cell RNA sequencing. It identified high heterogeneity and plasticity of ECs under normal and atherosclerotic conditions. Metabolic transcriptomic analysis showed that EndMT-derived fibroblast-like cells play a prominent role in atherosclerosis, with altered functions related to extracellular-matrix organization and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ling-Chang Tong, Zhi-Bin Wang, Jia-Qi Zhang, Yue Wang, Wei-Ye Liu, Hao Yin, Jia-Cheng Li, Ding-Feng Su, Yong-Bing Cao, Li-Chao Zhang, Ling Li
Summary: The study revealed that swiprosin-1 expressed in macrophages plays a key role in atherosclerosis development. Lack of swiprosin-1 can alleviate the progression of AS, making it a promising new therapeutic target.
CELL DEATH DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov, Anna Kotlyarova
Summary: Atherosclerosis is a significant issue in modern medicine, with many aspects not fully understood by clinicians. It develops through a complex chain of events involving various cells of the vascular wall and peripheral blood flow. Endothelial cells, as the lining of blood vessels, have a crucial role in vascular biology, not only acting as a barrier between blood flow and tissues but also regulating hemodynamics and influencing other cells in the vascular wall. Kruppel-like factors (KLFs) have diverse biological functions in different cells of the vascular wall, particularly KLF2 and KLF4, which play important roles in both normal vascular function and atherosclerosis.
Article
Medicine, Research & Experimental
Chaojun Tang, Lei Wang, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, Li Zhu
Summary: This study demonstrated that disturbed blood flow can induce platelet accumulation in atherosclerosis, with CLEC-2 gene knockout potentially reducing subendothelial accumulation of platelets and monocytes/macrophages, thereby ameliorating plaque formation.
Editorial Material
Physiology
Karolina Wielgus, Mikolaj Danielewski, Jaroslaw Walkowiak
Article
Biochemical Research Methods
Zuzanna Stachowiak, Irena Wojsyk-Banaszak, Katarzyna Jonczyk-Potoczna, Beata Narozna, Wojciech Langwinski, Aleksandra Szczepankiewicz
Summary: This study aimed to investigate whether a specific miRNA could be associated with the occurrence of pulmonary exacerbations (PEs) in children with cystic fibrosis (CF). The researchers sequenced extracellular vesicle (EV)-derived miRNA in sputum, exhaled breath condensate (EBC), and serum samples from pediatric patients during PE and stable CF stages. Four miRNAs were selected for validation and the results showed that a panel of all four miRNAs was the best predictive model of exacerbation.
JOURNAL OF BREATH RESEARCH
(2023)
Review
Genetics & Heredity
Mikolaj Danielewski, Joanna Zuraszek, Aleksandra Zielinska, Karl-Heinz Herzig, Ryszard Slomski, Jaroslaw Walkowiak, Karolina Wielgus
Summary: Paleogenetics has undergone significant changes since its inception. Initially, limited molecular techniques hindered ancient DNA analysis. However, advancements in scientific tools, as well as the popularity of this field, have led to remarkable achievements. Breakthroughs in next-generation sequencing technologies and DNA isolation protocols have enabled the sequencing of whole genomes even from highly fragmented aDNA samples.
Article
Medicine, General & Internal
Pawel Zebryk, Piotr Przymuszala, Jan Krzysztof Nowak, Tomasz Piorunek, Tatiana Mularek-Kubzdela, Mariusz Puszczewicz
Summary: This study evaluated the prevalence and clinical significance of SSc-related autoantibodies and compared the sensitivity of two line immunoblot assays. The findings indicate that different autoantibodies are associated with specific characteristics of SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Jan Brylak, Jan K. K. Nowak, Mariusz Szczepanik, Magdalena Holubiec, Pawel Kurzawa, Jaroslaw Walkowiak
Summary: In children, there is a positive correlation between blood eosinophil count and colonic eosinophil mucosal density. This association is more pronounced in patients with systemic inflammation and older than 12.4 years.
Article
Medicine, General & Internal
Urszula Daniluk, Paulina Krawiec, Elzbieta Pac-Kozuchowska, Lukasz Dembinski, Jan Stanislaw Bukowski, Aleksandra Banaszkiewicz, Anna Wozniuk-Kazmierczak, Elzbieta Czkwianianc, Jan Brylak, Jaroslaw Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dlubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn
Summary: The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014-2021 found that 11.4% of them had pancreatic involvement (PI), with acute pancreatitis (AP) diagnosed in 43.8% and asymptomatic hyperlipasemia (HL) or hyperamylasemia (HA) observed in 50.0%. Routine monitoring of pancreatic enzymes should be performed in patients with IBD, especially after the initiation of azathioprine (AZA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emilia Dybska, Jan Krzysztof Nowak, Jaroslaw Walkowiak
Summary: The study investigates the transcriptomic context of RUNX3 expression in blood monocytes and reveals its strong associations with genes involved in cell growth, signal transduction, and chromosome organization. The findings suggest that RUNX3 plays a role in regulating cell function and immune response.
Article
Biochemistry & Molecular Biology
Anna Gosciniak, Piotr Szulc, Waldemar Zielewicz, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
Summary: Red clover, a raw material with isoflavone content, was studied to evaluate the properties of its leaves and flowers. The study found that the ability to inhibit α-glucosidase, lipase, collagenase and antioxidant activity was not correlated with isoflavone content.
Article
Medicine, General & Internal
Irena Wojsyk-Banaszak, Barbara Wieckowska, Aleksandra Szczepankiewicz, Zuzanna Stachowiak, Marta Andrzejewska, Jerzy Juchnowicz, Maciej Kycler, Paulina Famulska, Marta Osinska, Katarzyna Jonczyk-Potoczna
Summary: The study aimed to assess the relationship between MRI and pulmonary function tests in CF children. Significant correlations were found between MRI perfusion scores and various PFT parameters. Differences in PFT variables were observed between patient groups divided based on perfusion scores. MRI could detect abnormalities earlier than PFTs in CF children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Irena Wojsyk-Banaszak, Zuzanna Stachowiak, Barbara Wieckowska, Marta Andrzejewska, Katarzyna Tapolska-Jozwiak, Aleksandra Szczepankiewicz, Paulina Sobkowiak, Anna Breborowicz
Summary: This study compared the predictive values of lung clearance index (LCI) in cystic fibrosis pediatric patients using different versions of software and found that although there were significant differences in LCI values measured with different software versions in stable condition, there was no significant difference during pulmonary exacerbations. Therefore, using recalculated LCI values does not affect the diagnostic accuracy of this parameter in cystic fibrosis pulmonary exacerbations.
Review
Health Care Sciences & Services
Kamila Bokayeva, Malgorzata Jamka, Michalina Banaszak, Aleksandra Makarewicz-Bukowska, Ada Adamczak, Maria Chrobot, Adrianna Janicka, Natalia Jaworska, Jaroslaw Walkowiak
Summary: Folic acid may have a positive effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
Article
Medicine, General & Internal
Malgorzata Jamka, Agata Czochralska-Duszynska, Edyta Madry, Aleksandra Lisowska, Katarzyna Jonczyk-Potoczna, Judyta Cielecka-Piontek, Pawel Bogdanski, Jaroslaw Walkowiak
Summary: This study aimed to evaluate the effects of CLA supplementation on bone mineral density and content in overweight or obese women. The results showed that three-month CLA supplementation did not improve bone health in this population. However, long-term intervention studies are needed to further investigate the potential benefits of CLA on bone health.
MEDICINA-LITHUANIA
(2023)
Article
Immunology
Jan Krzysztof Nowak, Emilia Dybska, Alex T. Adams, Jaroslaw Walkowiak
Summary: This study found that smoking specifically alters vital immune regulation genes in lymphocyte subtypes, especially CD4*, CD8*, and CD14* cells.
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
