Article
Cell Biology
Qingsong Fu, Tiantian Li, Chen Zhang, Xiaotian Ma, Liying Meng, Limin Liu, Kai Shao, Guanzhao Wu, Xing Zhu, Xiaoyun Zhao
Summary: The higher prevalence of metabolic syndrome (MetS) in women after menopause is associated with a decrease in circulating 17 beta-oestradiol. To explore novel treatments for MetS in women with oestrogen deficiency, researchers studied the effect of exogenous butyrate on diet-induced obesity and metabolic dysfunctions using ovariectomized (OVX) mice as a menopause model. Oral administration of sodium butyrate (NaB) reduced body fat content and blood lipids, increased whole-body energy expenditure, improved insulin sensitivity, and induced oestrogen receptor alpha (ER alpha) expression, activation of AMPK and PGC1 alpha phosphorylation, and enhanced mitochondrial aerobic respiration in cultured skeletal muscle cells. In conclusion, oral NaB improves metabolic parameters in OVX mice with diet-induced obesity, suggesting a potential new therapeutic approach for treating MetS in women with menopause.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Agriculture, Dairy & Animal Science
Ning Liu, Yun Ji, Ying Yang, Hai Jia, Xuemeng Si, Da Jiang, Yunchang Zhang, Zhaolai Dai, Zhenlong Wu
Summary: The study demonstrated the impact of dietary crude protein levels on regulating hepatic lipid metabolism in weaned piglets, specifically through alterations in lipid lipogenesis, lipolysis, oxidation, and gluconeogenesis processes.
Article
Pharmacology & Pharmacy
Haikang Zhou, Guoqing Li, Yang Wang, Rendong Jiang, Yicheng Li, Huhu Wang, Fei Wang, Hairong Ma, Li Cao
Summary: This study investigated the chondroprotective properties of NaB in inflammatory chondrocyte models and ACLT mouse models, revealing that NaB attenuated cartilage degradation by promoting autophagy to inhibit inflammation, oxidative stress, and apoptosis, thus reducing extracellular matrix degradation. The protective effects of NaB against OA were partially mediated by enhancing autophagy through the PI3K/Akt/mTOR pathway both in vitro and in vivo, suggesting NaB as a potential novel therapeutic approach for OA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ziwei Wang, Wan Shu, Rong Zhao, Yan Liu, Hongbo Wang
Summary: Sodium butyrate can promote the expression of RBM3 and indirectly downregulate the expression of SLC7A11 to stimulate ferroptosis in endometrial cancer cells. This study found that sodium butyrate can inhibit the progression of endometrial cancer in vitro and in vivo, and may be a promising cancer treatment strategy.
Article
Biochemistry & Molecular Biology
Sasa Miao, Yan Li, Tianming Mu, Xiaoming Wang, Wenyan Zhao, Ru Li, Xinyang Dong, Xiaoting Zou
Summary: This study examined the effects of adding different levels of coated sodium butyrate (CSB) on oxidation resistance, inflammatory reaction, lipid metabolism, and hepatic oxidative damage-related gene expression in aged laying hens. The results showed that CSB supplementation improved antioxidative function, reduced lipid accumulation and inflammation, and enhanced fatty acid catabolism in the liver. These findings suggest that dietary CSB supplementation has a protective effect on liver injury in aged laying hens.
Article
Medicine, Research & Experimental
Yanhong Xu, Shiqiao Peng, Xinyu Cao, Shengnan Qian, Shuang Shen, Juntao Luo, Xiaoying Zhang, Hongbin Sun, Wei L. Shen, Weiping Jia, Jianping Ye
Summary: The study revealed that SB administration through peritoneal injection in mice led to dose-dependent reduction in body temperature, activation of adenine nucleotide translocase (ANT) by butyrate causing potential collapse in mitochondrial membrane potential, resulting in transient mitochondrial dysfunction.
Article
Nutrition & Dietetics
Fernanda Rosa, Brooke Yelvington, Nathan Terry, Patricia Tripp, Hoy E. Pittman, Bobby L. Fay, Taylor J. Ross, James D. Sikes, Jessica B. Flowers, Fabiana Bar-Yoseph, Laxmi Yeruva
Summary: A randomized trial with neonatal piglets was conducted to evaluate the safety and effects of a plant-based formula containing almonds and buckwheat. The results showed that the plant-based formula was well tolerated and supported similar growth compared to a dairy-based formula.
Article
Nutrition & Dietetics
Monika Slupecka-Ziemilska, Stefan Grzegorz Pierzynowski, Paulina Szczurek, Kateryna Pierzynowska, Piotr Wychowanski, Blanka Seklecka, Maciej Koperski, Anna Starzynska, Dominika Szkopek, Janine Donaldson, Krzysztof Andrzejewski, Jaroslaw Wolinski
Summary: This study finds that feeding neonatal piglets with milk formula enriched with sodium butyrate can increase intestinal contractility and amplitude, increase muscle layer thickness and cell proliferation index in the intestine, and increase the expression of cholinergic and muscarinic receptors.
Article
Agriculture, Dairy & Animal Science
Keila Abadia Barbosa, Jansller Luiz Genova, Mayara Larissa Pazdziora, Liliana Bury De Azevedo, Geraldyne Nunes Wendt, Paulo Evaristo Rupolo, Gustavo de Amorim Rodrigues, Silvana Teixeira Carvalho, Luiz Fernando Costa e Silva, Leandro Batista Costa, Alysson Saraiva, Paulo Levi de Oliveira Carvalho
Summary: Two experiments were conducted to evaluate the effects of feed additive blends on growth performance, digestibility, and intestinal health in nursery piglets. The results showed that the complex blend (CB) had the most promising effects on the development of intestinal structure and function, without negatively affecting growth performance.
Article
Agriculture, Dairy & Animal Science
Xin Zhang, Yang Yun, Zheng Lai, Shuli Ji, Ge Yu, Zechen Xie, Hao Zhang, Xiang Zhong, Tian Wang, Lili Zhang
Summary: This study aimed to investigate the effects of Clostridium butyricum supplementation on hepatic lipid disorders in intrauterine growth restricted (IUGR) suckling piglets. The results showed that C. butyricum supplementation decreased the level of hepatic lipid disorders in IUGR piglets, promoting their growth and development.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Yunsheng Han, Chaohua Tang, Qingyu Zhao, Shijie Fan, Peilong Yang, Junmin Zhang
Summary: Butyrate functions in mitigating weanling piglet stress and improving intestinal health through mechanisms such as enhancing intestinal histology, modulating microbiota, and reducing inflammation.
Article
Cardiac & Cardiovascular Systems
Pengsheng Li, Fan Li, Ling Tang, Wenjing Zhang, Yan Jin, Haiwei Gu, Wuqiang Zhu
Summary: The study revealed distinct differences in the metabolic profiles of pig hearts at different postnatal stages. P1 hearts showed active anabolism of nucleotide and proteins, while P28 hearts demonstrated active posttranslational protein modification, metabolic switch from glucose to fatty acids, and reduced collagen to total protein ratio.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kim N. N. Cajachagua-Torres, Sophia M. M. Blaauwendraad, Hanan El Marroun, Hans Demmelmair, Berthold Koletzko, Romy Gaillard, Vincent W. V. Jaddoe
Summary: Fetal tobacco exposure is associated with changes in neonatal metabolite profiles, with different effects observed during different stages of maternal smoking.
Article
Veterinary Sciences
Tiantian Zhou, Bei Cheng, Lumin Gao, Fengyun Ren, Guanglun Guo, Teketay Wassie, Xin Wu
Summary: Maternal CAT supplementation positively influenced antioxidant ability and fatty acid metabolism in sows and piglets, improving milk production, antioxidant enzyme activity, offspring growth, and lipid metabolism, indicating potential benefits for utilizing CAT as a maternal supplement from late pregnancy to lactation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Na Kang, Zhenglin Ji, Yuxin Li, Ji Gao, Xinfeng Wu, Xiaoyang Zhang, Qinghui Duan, Can Zhu, Yue Xu, Luyao Wen, Xiaofei Shi, Wanli Liu
Summary: Damage-associated molecular patterns (DAMPs) derived from necrosis cells can activate DAMPs-sensing receptors and trigger inflammation. Failure to clear DAMPs can contribute to immunological diseases' pathogenesis. This review focuses on metabolite-derived DAMPs and their molecular mechanisms in exacerbating inflammation responses, as well as clinical interventions to mitigate their effects. It aims to inspire future thoughts and efforts in targeted medicinal interventions and therapy development for immunological diseases.
Article
Agriculture, Dairy & Animal Science
Adrian Lopez-Catalina, Valentin Costes, Ramon Peiro-Pastor, Helene Kiefer, Oscar Gonzalez-Recio
Summary: Epigenetic marks can explain part of the phenotypic variance in animal breeding models. Nanopore sequencing shows high correlation with bisulphite sequencing in identifying DNA methylation marks. Different sequencing methods highlight differentially methylated genes and positions of economic interest in animal breeding.