Article
Medicine, General & Internal
Hwi Seung Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
Summary: This study investigated the associations between non-alcoholic fatty liver disease (NAFLD) and triglyceride glucose (TyG)-related markers in healthy subjects in Korea. The study found that the TyG-waist circumference (WC) index was superior to the homeostasis model assessment of insulin resistance (HOMA-IR) for identifying NAFLD in healthy Korean adults, especially in the non-obese population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xiaojie He, Xinyue Huang, Yafang Qian, Ting Sun
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disorder associated with insulin resistance (IR). A novel index of IR called triglyceride glucose waist circumference (TyG-WC) reflects both visceral fat and hepatic steatosis. In this study, the relationship between TyG-WC and NAFLD in Japanese subjects with normal plasma glucose level was examined, and the threshold level of TyG-WC associated with NAFLD was determined.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Vo Duy Thong, Bui Thi Huong Quynh
Summary: This study aimed to investigate the correlation of serum ALT and AST with liver stiffness in Vietnamese NAFLD patients. The results showed that ALT levels were significantly higher in advanced fibrosis NAFLD patients. ALT had high sensitivity and specificity for detecting moderate to moderate liver fibrosis in NAFLD patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Danting Li, Meiyu Zhang, Shengli Wu, Huiwen Tan, Nong Li
Summary: This study aimed to detect NAFLD early in Chinese individuals by developing a nomogram model using clinical information, laboratory results, and ultrasound findings. The model identified six variables that were independently associated with NAFLD and showed high accuracy in predicting the risk of NAFLD in both the development and validation sets.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rongsheng Wang, Longlong Dai, Yanjia Zhong, Guobo Xie
Summary: The study found a stable positive correlation between TyG-BMI and NAFLD, with a non-linear relationship, threshold effects, and saturation effects. TyG-BMI was shown to better predict the risk of NAFLD compared to traditional indicators, especially in young, middle-aged, and non-obese individuals.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Endocrinology & Metabolism
Haojie Li, Zhan Shi, Xuejiao Chen, Junjie Wang, Jiacheng Ding, Shuoji Geng, Xinyuan Sheng, Songhe Shi
Summary: This study aimed to determine the association between six insulin resistance (IR) surrogates and non-alcoholic fatty liver disease (NAFLD) in older adults, and to compare their discriminatory abilities. The results showed that TyG-BMI and METS-IR had pronounced discrimination ability for NAFLD.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Jiaxin Qi, Xiayu Ren, Yanjuan Hou, Yaqing Zhang, Yanru Zhang, Enxue Tan, Lihua Wang
Summary: This study found that the TyG index is an independent risk factor for hyperuricemia (HUA) in patients with nonalcoholic fatty liver disease (NAFLD). The increase of the TyG index level is closely related to the occurrence and development of HUA in NAFLD patients.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Fangli Zhou, Yan Wang, Yujue Li, Mengjia Tang, Shan Wan, Haoming Tian, Xiang Chen
Summary: The study found that circulating sclerostin levels were significantly lower in NAFLD patients compared to controls, and were negatively correlated with multiple metabolic parameters in NAFLD patients. Mice fed on a high-fat diet had reduced bone mass and lower sclerostin expression levels. Therefore, liver-lipid-bone interactions may play a key role in abnormal bone metabolism in NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Teruki Miyake, Bunzo Matsuura, Shinya Furukawa, Osamu Yoshida, Masashi Hirooka, Teru Kumagi, Toru Ishihara, Sayaka Kanzaki, Hironobu Nakaguchi, Masumi Miyazaki, Yoshiko Nakamura, Yasunori Yamamoto, Yohei Koizumi, Yoshio Tokumoto, Eiji Takeshita, Yoshio Ikeda, Masanori Abe, Kohichiro Kitai, Yoichi Hiasa
Summary: This study examined the relationship between fatty liver disease and the development of impaired fasting glucose (IFG), finding that FLD is a risk factor for IFG onset in both nonalcoholic men and women, regardless of liver enzyme levels.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Medicine, General & Internal
Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Waseem Wahood, Sami Ghazaleh, Ziad Abuhelwa, Wasef Sayeh, Nameer Aladamat, Rami Musallam, Reem Matar, Saif-Eddin Malhas, Ragheb Assaly
Summary: This study conducted a systematic review and meta-analysis to assess the significance of the triglyceride-glucose (TyG) index in predicting the incidence of nonalcoholic fatty liver disease (NAFLD). The results showed that a higher TyG index is associated with higher odds of NAFLD. The TyG index may serve as an independent predictive tool to screen high-risk NAFLD patients in primary care settings. However, further large-scale prospective cohort studies are needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Food Science & Technology
Lingchong Liu, Yu Wang, Jing Zhang, Chao Wang, Youbao Li, Weichang Dai, Chunhong Piao, Junmei Liu, Hansong Yu, Xia Li, Yuhua Wang, Jingsheng Liu
Summary: This article reviews the pathogenesis of alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), summarizes the health effects of probiotics in the treatment of these two liver diseases, and discusses the mechanisms of probiotic therapy, aiming to provide a theoretical basis for future research.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang, Yilong Wang
Summary: Elevated levels of both baseline and long-term updated cumulative average TyG index can independently predict stroke and ischemic stroke but not intracerebral hemorrhage in the general population during an 11-year follow-up. The study found a linear association between TyG index and stroke outcomes, with higher TyG index associated with increased risk of stroke.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Endocrinology & Metabolism
Qin Ling, Jiawei Chen, Xiao Liu, Yi Xu, Jianyong Ma, Peng Yu, Kai Zheng, Fuwei Liu, Jun Luo
Summary: A comprehensive meta-analysis revealed that the triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD). The risk of NAFLD increased linearly with each additional unit of the TyG index, and the association was stronger in females than in males.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaozhong Li, Fenfang Zhan, Tian Peng, Zhen Xia, Juxiang Li
Summary: This study investigated the association between the TyG index and NAFLD in AF patients. The results showed a significant correlation between the TyG index and NAFLD, indicating that the TyG index may be a useful marker for predicting NAFLD in AF patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Yoo Jeong Lee, Sooyeon Lee, In Cheol Hwang, Hong Yup Ahn
Summary: This study investigated the relationship between insulin resistance and suicidal ideation, and found that the TyG index was significantly associated with suicidal ideation in women, especially in the low-risk group for suicide.
JOURNAL OF AFFECTIVE DISORDERS
(2024)