Article
Immunology
Sanghun Lee, Yu Zhang, Margaret Newhams, Tanya Novak, Paul G. Thomas, Peter M. Mourani, Mark W. Hall, Laura L. Loftis, Natalie Z. Cvijanovich, Keiko M. Tarquinio, Adam J. Schwarz, Scott L. Weiss, Neal J. Thomas, Barry Markovitz, Melissa L. Cullimore, Ronald C. Sanders, Matt S. Zinter, Janice E. Sullivan, Natasha B. Halasa, Melania M. Bembea, John S. Giuliano, Katri Typpo, Ryan A. Nofziger, Steven L. Shein, Michele Kong, Bria M. Coates, Scott T. Weiss, Christoph Lange, Helen C. Su, Adrienne G. Randolph
Summary: This study evaluated the association of common variants in interferon regulatory genes with susceptibility to severe influenza infection in children. Through targeted sequencing and gene expression analysis, it was found that common variants in the DDX58 gene were associated with the impact on RIG-I and IFN immunity and susceptibility to severe disease.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Parisa Feizollahi, Mohammad Hossein Zamanian, Sara Falahi, Farhad Salari, Zahra Mahmoudi, Elham Faryadi, Ali Gorgin Karaji, Alireza Rezaiemanesh
Summary: This study investigated the association between three SNPs in the coding region of IFIH1 and DDX58 genes and susceptibility to COVID-19 in the Kermanshah population, Iran. The results showed that the rs10813831(A>G) polymorphism in the DDX58 gene may be associated with the severity of COVID-19.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Immunology
Cheng Wang, Wenkai Zhou, Yin Liu, Yue Xu, Xuan Zhang, Chengyu Jiang, Minghong Jiang, Xuetao Cao
Summary: This study reveals a non-canonical role of nuclear RIG-I in the induction of cellular apoptosis, besides its activation of IFN-I expression as the cytosolic innate sensor. The interaction between nuclear RIG-I and APEX1 provides new insight into the regulation of infection, IFN-I, and autoimmune diseases.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Infectious Diseases
Ya-Ping Li, Chen-Rui Liu, Hui-Ling Deng, Mu-Qi Wang, Yan Tian, Yuan Chen, Yu-Feng Zhang, Shuang-Suo Dang, Song Zhai
Summary: This research aimed to explore the association between RIG-I-like receptor pathways and the risk or severity of EV71-HFMD. The study found that DDX58 promoter methylation was significantly associated with severe HFMD and DDX58 expression levels were significantly lower in severe patients. The genotype frequencies of DDX58 rs3739674 showed statistically significant differences between mild and severe groups. Various epigenetic biomarkers of DDX58 may be used as indicators to help clinicians identify EV71-HFMD patients with a tendency towards severity.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Genetics & Heredity
Lev Prasov, Brenda L. Bohnsack, Antonette S. El Husny, Lam C. Tsoi, Bin Guan, J. Michelle Kahlenberg, Edmundo Almeida, Haitao Wang, Edward W. Cowen, Adriana A. De Jesus, Priyam Jani, Allison C. Billi, Sayoko E. Moroi, Rachael Wasikowski, Izabela Almeida, Luciana N. Almeida, Fernando Kok, Sarah J. Garnai, Shahzad Mian, Marcus Y. Chen, Blake M. Warner, Carlos R. Ferreira, Raphaela Goldbach-Mansky, Sun Hur, Brian P. Brooks, Julia E. Richards, Robert B. Hufnagel, Johann E. Gudjonsson
Summary: Singleton-Merten syndrome (SGMRT) is a rare immunogenetic disorder characterized by features such as juvenile open-angle glaucoma, psoriasiform skin rash, and aortic calcifications. A study identified a novel DDX58 variant, expanding the genotypic spectrum of the disease. Furthermore, detailed ocular and dermatological phenotypes were described for the first time, shedding light on the molecular pathogenesis of SGMRT.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Medicine, Research & Experimental
Tianming Le, Xin He, Jianhua Huang, Shuai Liu, Yang Bai, Kemin Wu
Summary: The study showed that GAS5 induces SMC apoptosis and subsequent AAA onset by activating the EZH2-mediated RIG-I signaling pathway. Overexpression of EZH2 can inhibit AAA formation and SMC apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Infectious Diseases
Ya-Ping Li, Chen-Rui Liu, Hui-Ling Deng, Mu-Qi Wangid, Yan Tian, Yuan Chen, Yu-Feng Zhang, Shuang-Suo Dang, Song Zhai
Summary: This study aimed to explore the association between the RIG-I-like receptor pathways and the risk or severity of hand, foot, and mouth disease caused by enterovirus 71 (EV71-HFMD). The results showed that the expression and promoter methylation of DDX58 were closely related to the progression of EV71 infection, especially in severe EV71-HFMD patients. The expression level of DDX58 was significantly lower in severe patients. Moreover, DDX58 polymorphisms played an important role in the severity of EV71-HFMD.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Anne K. Kronborg Hansen, Magdalena Dubik, Joanna Marczynska, Bhavya Ojha, Estanislao Nistal-Villan, Gloria Gonzalez Aseguinolaza, Dina S. Arengoth, Trevor Owens, Reza Khorooshi
Summary: This study investigated the potential therapeutic effect of activating the RIG-I signaling pathway to promote the production of IFN beta within the central nervous system (CNS) and its impact on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The results demonstrate that intrathecal administration of AAV-CM resulted in sustained IFN beta expression within the CNS and suppressed the development of EAE. These findings suggest that targeting the downstream signaling pathway of RIG-I represents a promising therapeutic strategy for inflammatory CNS diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jiahui Peng, Yusha Wang, Xu Han, Changming Zhang, Xiang Chen, Ying Jin, Zhaohui Yang, Yu An, Jiahui Zhang, Zhengzhao Liu, Yinghua Chen, Erzhi Gao, Yangyang Zhang, Feng Xu, Chunxia Zheng, Qing Zhou, Zhihong Liu
Summary: A novel DDX58 R109C variant that can cause lupus nephritis was identified, indicating a connection between IFNopathy and LN. Targeted therapy based on the pathogenicity of this variant effectively reduced the IFN signal.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Immunology
Hao Wang, Jie Yin, Xinyan Gu, Wenhui Shao, Zhanjun Jia, Hongbing Chen, Weiwei Xia
Summary: RIG-I is a cytosolic pattern recognition receptor that plays a role in both antiviral and non-viral infectious diseases. It is widely expressed in the cardiovascular system and has potential research value in the treatment of cardiovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yangfu Jiang, Hongying Zhang, Jiao Wang, Jinzhu Chen, Zeyu Guo, Yongliang Liu, Hui Hua
Summary: RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses. Manipulation of RLRs signaling represents an opportunity for clinically relevant cancer therapy, as therapeutic targeting RLRs can not only provoke anti-infection effects but also induce anticancer immunity or sensitize immune-cold tumors to immune checkpoint blockade.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Chemistry, Medicinal
Maria Batool, Moon Suk Kim, Sangdun Choi
Summary: RNA viruses, such as coronavirus, evade the host immune response by manipulating RLRs receptors. RIG-I and MDA5 sense different types of RNA, and understanding the structure of these receptors may lead to effective antiviral therapies.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Microbiology
Xing Liu, Yijie Ma, Kathleen Voss, Michiel van Gent, Ying Kai Chan, Michaela U. Gack, Michael Gale, Bin He
Summary: This study demonstrates that the HSV-1-encoded γ(1)34.5 protein inactivates RIG-I, a key RNA sensor in host cells, to dampen antiviral innate immunity. By targeting RIG-I, HSV-1 inhibits its interaction with the chaperone protein 14-3-3 epsilon, ultimately blocking the cytosol-to-mitochondrial translocation of RIG-I. The viral evasion of cytosolic RNA sensing is highlighted as a crucial factor in the evolutionary arms race between a large DNA virus and its host.
Article
Virology
Zhen Wang, Shaotang Ye, Congwen Yao, Ji Wang, Jianwei Mao, Liang Xu, Yongbo Liu, Cheng Fu, Gang Lu, Shoujun Li
Summary: In this study, the RIG-I gene of beagle dogs was cloned and characterized for its expression and subcellular localization. Overexpression of canine RIG-I suppressed CIV replication, but CIV's NS1 protein strongly inhibited RIG-I-mediated immune response. Novel interactions between CIV matrix proteins (M1 and M2) and canine RIG-I were identified.
Article
Cell Biology
Adrian Baris, Eugenia Fraile-Bethencourt, Jaiden Eubanks, Sokchea Khou, Sudarshan Anand
Summary: Activation of nucleic acid sensors in endothelial cells (ECs) can induce inflammation in various diseases. The activation of cytosolic RNA sensor, RIG-I, reduces EC survival and angiogenesis, and triggers tissue-specific gene expression. The presence of a RIG-I-dependent 7 gene signature affects angiogenesis, inflammation, and coagulation. TYMP, a key mediator of RIG-I-induced EC dysfunction, can be targeted pharmacologically to rescue RIG-I-induced effects in ECs.
CELL DEATH & DISEASE
(2023)
