Article
Oncology
Daijing Nie, Jing Zhang, Fang Wang, Xvxin Li, Lili Liu, Wei Zhang, Panxiang Cao, Xue Chen, Yang Zhang, Jiaqi Chen, Xiaoli Ma, Xiaosu Zhou, Qisheng Wu, Ming Liu, Mingyue Liu, Wenjun Tian, Hongxing Liu
Summary: The study suggests that heterozygous mutations in Fanconi anemia genes can contribute to hematologic disorders, particularly aplastic anemia and leukemia. Different genes have varying frequencies of mutations, with some genes showing associations with specific subgroups of hematologic malignancies.
FRONTIERS OF MEDICINE
(2022)
Article
Hematology
Wenrui Yang, Xin Zhao, Guangsheng He, Hong Chang, Bing Han, Sujun Gao, Shunqing Wang, Tong Chen, Fei Li, Yi Wang, Xiaoyan Ge, Rong Fu, Zheng Ge, Yingmei Li, Hong Liu, Xinjian Liu, Miao Miao, Liansheng Zhang, Fengkui Zhang
Summary: Hetrombopag is the only CFDA-approved thrombopoietin receptor agonist for severe aplastic anemia in China. A post hoc analysis of a phase II clinical trial showed that hetrombopag had a powerful and rapid iron chelation effect.
ANNALS OF HEMATOLOGY
(2022)
Review
Medicine, General & Internal
Toni Valkovic, Marija Stanic Damic
Summary: Iron plays an important role in the survival and reproduction of fungal pathogens, and there is evidence linking invasive fungal infections to iron or iron overload. Understanding the association between iron and iron overload with susceptibility to invasive fungal infections is crucial, especially for patients with hematological malignancies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Jiaojiao Li, Wei Zhang
Summary: This review discusses the regulatory mechanism of ferroptosis and the treatment opportunities for targeting ferroptosis in hematologic malignancies. It highlights the potential of small molecules in inducing ferroptosis through targeted iron metabolism and lipid peroxidation, and the synergistic effect of ferroptosis inducers with other chemotherapeutic drugs. It emphasizes the significance of ferroptosis in hematologic malignancies and suggests the need for further experimental studies.
Article
Hematology
John Chapin, Alan R. Cohen, Ellis J. Neufeld, Elliott Vichinsky, Patricia J. Giardina, Jeanne Boudreaux, Binh C. Le, Kristy Kenney, Sean Trimble, Alexis A. Thompson
Summary: Thalassaemia is a genetic disorder causing anaemia and dependence on transfusions, with recent clinical advancements leading to reduced mortality and potential future gene therapies. Research revealed older patients with more iron-related comorbidities and complications, while younger patients had excess liver and heart iron and were on combination chelation therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Multidisciplinary Sciences
Yesim Aydinok
Summary: Combination chelation therapy is a viable option for transfusion-dependent thalassemia patients who have not achieved iron balance with monotherapy or need intensified treatment for rapid iron reduction. It allows for a more personalized approach, improving tolerability, adherence, and quality of life. Real-life data highlights the importance of compliance in achieving meaningful reduction in iron overload compared to monotherapy.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Shizhen Li, Xiangyu Zhang
Summary: Iron plays essential roles in cardiovascular diseases, with iron deficiency having detrimental effects in heart failure and pulmonary arterial hypertension patients. Ferroptosis, an iron-dependent cell death, has been reported in cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy may be a potential strategy to address iron overload-related disorders in CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Toxicology
Ruiying Cheng, Rajitha Gadde, Yingfang Fan, Neha Kulkarni, Nachiket Shevale, Kai Bao, Hak Soo Choi, Swati Betharia, Jonghan Kim
Summary: N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a lipophilic metal chelator and antioxidant used for mercury poisoning. It has shown potential in binding to other metals like lead and iron. In this study, it was found that NBMI selectively binds to ferrous iron, protecting neuroblastoma cells from high iron-mediated cytotoxicity and reducing reactive oxygen species. Furthermore, NBMI effectively reduced iron accumulation in the brain and liver of iron-loaded mice, with a superior safety profile compared to the commonly used iron chelator, DFP. These findings highlight the neuroprotective and therapeutic potential of NBMI for neurodegenerative diseases associated with brain iron accumulation.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Nutrition & Dietetics
William Kardasis, Ethan R. Naquin, Richa Garg, Tejas Arun, Jyotsna S. Gopianand, Eshani Karmakar, Jaya P. Gnana-Prakasam
Summary: Iron is a crucial micronutrient for athletes, but impaired iron levels can hinder athletic performance. Prolonged exercise can affect iron absorption, utilization, and storage, increasing the risk of iron deficiency. On the other hand, iron overload may initially enhance performance but can have detrimental health consequences in the long term. Proper management of iron intake is crucial for improving athletic performance and overall well-being.
Article
Hematology
Vladimir Riabov, Maximilian Mossner, Alexandra Stoehr, Johann-Christoph Jann, Alexander Streuer, Nanni Schmitt, Antje Knaflic, Verena Nowak, Nadine Weimer, Julia Oblaender, Iris Palme, Christiane Schumann, Claudia D. Baldus, Torsten J. Schulze, Patrick Wuchter, Henning Roehl, Ahmed Jawhar, Christel Weiss, Tobias Boch, Georgia Metzgeroth, Martin Neumann, Wolf-Karsten Hofmann, Florian Nolte, Daniel Nowak
Summary: The expression of ERFE and GDF15 in MDS patients was found to be highly aberrant, with ERFE expression unexpectedly relevant for MDS prognosis. ERFE overexpression predicted superior overall survival in certain MDS subgroups, suggesting a possible involvement of ERFE in the molecular pathogenesis of MDS.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, General & Internal
Jessica van Hattem, Philip Maes, Tonya Marianne Esterhuizen, Ann Devos, Martin Ruppert, Jaques van Heerden
Summary: Limited data on erythrocytapheresis in children, adolescents, and young adults have been published. This study aimed to evaluate the effectiveness of erythrocytapheresis, either alone or in combination with iron chelation therapy, in managing iron overload in patients with hemoglobinopathies. The results showed that erythrocytapheresis significantly reduced serum ferritin levels and had a better effect compared to iron chelation therapy alone. This study demonstrates that erythrocytapheresis is a promising therapy for treating transfusion-related iron overload.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Elizabeta Nemeth, Tomas Ganz
Summary: Iron regulation in organisms is primarily controlled by the interaction of the iron-regulatory peptide hormone hepcidin and its receptor ferroportin, which plays a crucial role in maintaining iron homeostasis. Dysregulation of hepcidin can lead to iron overload disorders or iron deficiency, affecting iron delivery and compensatory erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Mengdie Su, Yanjia Zhao, Mei Li, Chenyang Jia, He Liu, Yue Zhang, Weiwei Li, Ying Peng, Jiang Zheng
Summary: This study identified two hydroxylated metabolites of Deferasirox (DFS) in rat liver microsomes, which were also detected in bile and urine. CYP1A2 and CYP3A4 were found to be the main enzymes responsible for the metabolic activation of DFS. DFS exhibited cytotoxicity towards primary hepatocytes, but pretreatment with ketoconazole and 1-aminobenzotrizole reduced its toxicity.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Reem Aldwaik, Tamara Abu Mohor, Israa Idyabi, Salam Warasna, Shatha Abdeen, Bashar Karmi, Rania Abu Seir
Summary: Management of beta-thalassemia in the West Bank presents challenges due to the lack of available therapies, leading to recurrent transfusions. Characteristics of patients include anemia, iron overload, and abnormal liver function tests. Iron chelation medication choice is associated with serum ferritin levels, highlighting the need for personalized assessment and follow-up protocols.
FRONTIERS IN MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Kathleen E. Sullivan, Shana R. Lavin, Shannon Livingston, Mitchell Knutson, Eduardo V. Valdes, Lori K. Warren
Summary: Iron overload disorder is prevalent in black rhinoceroses, and the use of an oral iron chelator showed potential for treatment in horses. The study found that the chelator increased urinary iron output in horses without any adverse effects.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Review
Oncology
Giuseppe Saglio, Elias Jabbour
LEUKEMIA & LYMPHOMA
(2018)
Article
Oncology
Laura M. Castello, Marco Leone, Aloe Adamini, Sara Castiglia, Katia Mareschi, Ivana Ferrero, Marco De Gobbi, Fabrizio Carnevale-Schianca, Franca Fagioli, Massimo Berger
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2018)
Letter
Hematology
Giacomo Andreani, Matteo Dragani, Anna Serra, Paolo Nicoli, Marco De Gobbi, Daniela Cilloni
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Hematology
Cristina Barale, Rouslan Senkeev, Franca Napoli, Marco De Gobbi, Angelo Guerrasio, Alessandro Morotti, Isabella Russo
THROMBOSIS AND HAEMOSTASIS
(2019)
Letter
Oncology
Daniela Cilloni, Giacomo Andreani, Matteo Dragani, Marco De Gobbi, Giuseppe Saglio
LEUKEMIA & LYMPHOMA
(2020)
Article
Hematology
Giacomo Andreani, Gianluca Fadda, Dario Gned, Matteo Dragani, Giovanni Cavallo, Valentina Monticone, Alessandro Morotti, Marco De Gobbi, Angelo Guerrasio, Anna Maria Barbui, Antonio D'Avolio, Daniela Cilloni
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2019)
Letter
Hematology
Valentina Rosso, Jessica Petiti, Matteo Dragani, Giacomo Andreani, Eleonora Croce, Marco Lo Iacono, Giuseppe Saglio, Carmen Fava, Daniela Cilloni
ANNALS OF HEMATOLOGY
(2020)
Review
Hematology
Giuseppe Saglio, Robert P. Gale
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Oncology
Valentina Gaidano, Valerio Tenace, Nathalie Santoro, Silvia Varvello, Alessandro Cignetti, Giuseppina Prato, Giuseppe Saglio, Giovanni De Rosa, Massimo Geuna
Review
Hematology
Claudia Vener, Rita Banzi, Federico Ambrogi, Annalisa Ferrero, Giuseppe Saglio, Gabriella Pravettoni, Milena Sant
Biographical-Item
Oncology
Giuseppe Saglio, Gianantonio Rosti, Rudiger Hehlmann, Andreas Hochhaus, Robert Peter Gale
Editorial Material
Hematology
Massimo Breccia, Giuseppe Saglio
Summary: The role of IFN alpha in chronic myeloid leukaemia patients who have achieved a deep molecular response is still unclear. The study by Irani et al., which examines the effects of the drug in combination with a second-generation tyrosine kinase inhibitor, provides a foundation for further clinical studies aiming to increase the rate of DMR and potentially successful discontinuation.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Giuseppe Saglio, Philipp le Coutre, Jorge Cortes, Jiri Mayer, Philip Rowlings, Francois-Xavier Mahon, Glenn Kroog, Kyna Gooden, Milayna Subar, Neil P. Shah
ANNALS OF HEMATOLOGY
(2017)
Article
Hematology
Chiara Piubelli, Annalisa Castagna, Giacomo Marchi, Monica Rizzi, Fabiana Busti, Sadaf Badar, Monia Marchetti, Marco De Gobbi, Antonella Roetto, Luciano Xumerle, Eda Suku, Alejandro Giorgetti, Massimo Delledonne, Oliviero Olivieri, Domenico Girelli
AMERICAN JOURNAL OF HEMATOLOGY
(2017)
Article
Hematology
Alessandra Iurlo, Sara Galimberti, Elisabetta Abruzzese, Mario Annunziata, Massimiliano Bonifacio, Roberto Latagliata, Patrizia Pregno, Dario Ferrero, Federica Sora, Ester Maria Orlandi, Carmen Fava, Daniele Cattaneo, Cristina Bucelli, Gianni Binotto, Ester Pungolino, Mario Tiribelli, Antonella Gozzini, Gabriele Gugliotta, Fausto Castagnetti, Fabio Stagno, Giovanna Rege-Cambrin, Bruno Martino, Luigiana Luciano, Massimo Breccia, Simona Sica, Monica Bocchia, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Giorgina Specchia, Agostino Cortelezzi, Michele Baccarani
ANNALS OF HEMATOLOGY
(2018)
