Review
Chemistry, Multidisciplinary
Juan Esteban Montoya Cardona, Dounia Louaguef, Eric Gaffet, Nureddin Ashammakhi, Halima Alem
Summary: Despite some delays in clinical implementation, functionalized magnetic and photothermal nanostructures remain the most promising way to target hyperthermia treatment of cancer towards local tumor regions. The synthesis method and parameters play a crucial role in optimizing the physicochemical properties for efficient energy transduction into locally released heat. This review aims to provide the latest applications and prospects of nanomaterials for hyperthermia properties.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Nanoscience & Nanotechnology
Ruizhi Wang, Guofeng Zhou, Yuchan Yang, Shiqing Wang, Shanshan Gao, Dongmei Gao, Xiaolin Wang
Summary: This article studies the advantages of gold as a photothermal material in deep tissue penetration and high spatial accuracy. Through the study and characterization of gold with different sizes and shapes, it is found that core-shell nanoparticles have excellent photothermal conversion performance and show great potential in targeted photothermal therapy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yara Kadria-Vili, Oara Neumann, Yage Zhao, Peter Nordlander, Gary Martinez, James A. Bankson, Naomi J. Halas
Summary: A promising clinical trial using gold-silica core-shell nanostructures for near-infrared photothermal therapy of prostate cancer has been reported. In this study, PEGylated Gd2O3-mesoporous silica/gold core/shell nanoparticles were synthesized, which not only have near-infrared photothermal properties but also provide sufficient MRI contrast for visualization at therapeutic doses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Multidisciplinary
Chan Zheng, Ziqiao Li, Tiantian Xu, Ling Chen, Fang Fang, Dai Wang, Pinqiang Dai, Qianting Wang, Xinyu Wu, Xiaohui Yan
Summary: Magnetic helical micro/nanoswimmers, inspired by E. coli bacterium, can perform controlled locomotion in various fluids and possess photothermal attributes and high surface areas. They are envisioned for applications in biomedical, environmental purification, etc.
APPLIED MATERIALS TODAY
(2021)
Article
Nanoscience & Nanotechnology
Xiangyu Qi, Gang Wang, Peng Wang, Yao Pei, Caiyun Zhang, Miao Yan, Pengfei Wei, Geng Tian, Guilong Zhang
Summary: A novel protein corona-modified nanoplatform has been developed for tumor-targeting photothermal and chemodynamic synergistic therapy. The nanoplatform exhibits high photothermal conversion efficiency and excellent stability. It shows strong chemodynamic therapy ability and can induce cancer cell death. Additionally, it can accurately diagnose cancer, making it a promising candidate for photothermal and chemodynamic synergistic theranostics.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Oana-Georgiana Dragos-Pinzaru, Gabriela Buema, Dumitru-Daniel Herea, Horia Chiriac, Nicoleta Lupu, Anca Emanuela Minuti, George Stoian, Daniel Shore, Valerie C. C. Pierre, Ibro Tabakovic, Bethanie J. H. Stadler
Summary: Alternative physical therapies for cancer, particularly the magneto-mechanical actuation of magnetic nanoparticles, have gained increasing interest in recent years. This study demonstrates the biocompatibility enhancement of magnetic nanowires through gold coating, enabling their use in cancer therapy and MRI applications.
Article
Nanoscience & Nanotechnology
Varvara Athanasiou, Dimitra Stavroulaki, Foteini Arfara, Dimitrios Kampras, Ioannis Kleideris, Niki Roumelioti, Panagiota G. Fragouli, Georgios Patias, David Haddleton, Hermis Iatrou
Summary: A facile strategy for synthesizing hybrid nanoparticles with gold nanoshells that absorb NIR light was presented, allowing for fine-tuning of their optical properties. The nanoparticles showed significant temperature increase when irradiated with a low power laser, indicating their potential application in photothermal therapy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Ariana S. C. Goncalves, Carolina F. Rodrigues, Natanael Fernandes, Duarte de Melo-Diogo, Paula Ferreira, Andre F. Moreira, Ilidio J. Correia
Summary: By dual-functionalizing Polyethylene glycol methyl ether (PEG-CH3) and Gelatin (GEL) on gold core silica shell (AuMSS) nanorods, and combining them with IR780 molecule, the uptake by HeLa cancer cells was enhanced and photothermal and photodynamic therapy were successfully achieved, effectively promoting the ablation of cancer cells.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Chemistry, Physical
Jin Li, Xiao-Peng Liu, Wen-Qi Ye, Zhang-Run Xu
Summary: A novel photothermal quantitative method based on the etching of MnO2-coated gold nanoparticles was developed for the determination of alkaline phosphatase (ALP) activity using a household thermometer as a visual readout. The photothermal effect of the nanoparticles was significantly enhanced by the MnO2 shell, and the etching of the nanoparticles caused a gradual decrease in the temperature increment of the solution. The method showed a wide linear range and a low detection limit, and could potentially be applied for screening enzyme inhibitors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Inorganic & Nuclear
Paolo Arosio, Francesco Orsini, Francesca Brero, Manuel Mariani, Claudia Innocenti, Claudio Sangregorio, Alessandro Lascialfari
Summary: In this perspective article, we review the most significant case studies on magnetic nanoparticles for potential applications in nanomedicine, especially in magnetic resonance imaging. The dependence of the relaxation behavior of magnetic nanoparticles on their chemico-physical properties is discussed in detail. The correlations between the efficiency of magnetic nanoparticles as contrast agents in magnetic resonance imaging and their magnetic core (mainly iron oxides), size and shape, and the coating and solvent used for biocompatibility and dispersibility in physiological media are critically reviewed. Finally, the heuristic model proposed by Roch and coworkers is presented, and its advantages and limitations are highlighted through the analysis of a large amount of experimental data.
DALTON TRANSACTIONS
(2023)
Article
Biotechnology & Applied Microbiology
Carolina F. Rodrigues, Natanael Fernandes, Duarte de Melo-Diogo, Paula Ferreira, Ilidio J. Correia, Andre F. Moreira
Summary: The study successfully developed a tumor-targeted therapy by functionalizing AuMSS nanorods loaded with AO with PEI and HA. The results demonstrated that functionalization improved the internalization of nanoparticles, leading to enhanced therapeutic effects in combinatorial treatment.
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Evangelia Christou, John R. Pearson, Ana M. Beltran, Yilian Fernandez-Afonso, Lucia Gutierrez, Jesus M. de la Fuente, Francisco Gamez, Maria L. Garcia-Martin, Carlos Caro
Summary: The development of nanoplatforms capable of multimodal imaging and combined therapies has great potential in improving diagnostic accuracy and therapy success. In this study, a new seed-assisted method was used to synthesize Au@Fe nanoparticles with a flower-like structure, which exhibited excellent features as both MRI and CT Contrast Agents. These nanoparticles also showed considerable energy-to-heat conversion under both Alternating Magnetic Fields and Near-Infrared light. Moreover, they exhibited very low cytotoxicity, confirming their potential for theranostics applications.
Article
Chemistry, Physical
Ying Zhang, Hongjun Yan, Jiawen Tang, Peiyuan Li, Rixiang Su, Haiyi Zhong, Wei Su
Summary: Bacteria are becoming increasingly resistant to antibiotics, necessitating the need for new therapies. Photodynamic therapy and photothermal therapy are effective sterilization methods. In this study, silica-coated gold nanorods and curcumin were used to form PTT/PDT dual-mode antibacterial nanocomposites (AuNRs@Cur). AuNRs@Cur exhibited higher singlet oxygen yield and photothermal conversion efficiency, improving the utilization rate of photosensitizer and enhancing the photoinactivation effect of bacteria.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Physical
Thais Lazzarotto Braga, Pollyanna Cristina Vincenzi Conrado, Leticia Graziela Zavadzki Silva, Eduardo Victor Bergmann, Ana Claudia Pedrozo da Silva, Patricia de Souza Bonfim de Mendonca, Jane Martha Graton Mikcha, Leandro S. Herculano, Luis Carlos Malacarne, Edvani Curt i Muniz, Camila Fabiano de Freitas, Wilker Caetano
Summary: The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) using methylene blue (MB) and gold nanoparticles (AuNPs) has shown promise as an effective treatment for microbial diseases. The use of ABA triblock Pluronic (R) P-123 copolymer as a carrier and stabilizing agent for AuNPs has proven to be efficient in obtaining reproducible samples. The synthesis of AuNPs presented plasmonic resonance peaks ranging from 535 to 554 nm, indicating spherical AuNPs. The combination therapy demonstrated both photodynamic and photothermal effects, with synergy observed in the generation of singlet oxygen and heat. The samples showed significant antifungal and antibacterial activity, making this approach a potential method for treating microbial infections.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Leila Gholami, Khatereh Khorsandi, Reza Fekrazad
Summary: The use of tissue engineering in dentistry for reconstructing lost tooth structures and periodontium has shown great therapeutic success. Photobiomodulation using red and near-infrared lasers can enhance the viability of periodontal ligament stem cells and affect ROS production and cell cycle, with greater effects observed in the pulsed mode of 940 nm irradiation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Engineering, Environmental
Elahe Amini, Cristina Valls, Hossein Yousefi, M. Blanca Roncero
Summary: This study prepared transparent cellulose-grafted-PLA nanocomposite films by grafting polylactide (PLA) onto cellulose. It was found that incorporating zinc oxide nano particles and PLA can enhance the mechanical, barrier, and optical properties of the films.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Letter
Clinical Neurology
Elahe Amini, Zahra Azad, Reza Mirshahi, Mohammad Rohani
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Maryam Jalessi, Zahra Azad, Franco Valzania, Francesco Cavallieri, Mohammad Farhadi, Zeinab Gholibeigian
Summary: This study found that olfactory impairment is common in various subtypes of NBIA disorder and could potentially be considered a discriminative biomarker. NBIA patients had significantly lower olfactory scores compared to the control group.
NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Nanoscience & Nanotechnology
Jeff W. M. Bulte, Ali Shakeri-Zadeh
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Reza Fekrazad, Gholam Ali Gholami, Pooyan Sadr Eshkevari, Hanieh Nokhbatolfoghahaei, Sadra Mohaghegh
Summary: The feasibility of Nd:YAG laser therapy in treating RAS lesions was assessed, and focused and defocused scanning techniques were compared. Photobiomodulation showed better pain relief and shorter pain duration compared to the placebo group.
DENTAL AND MEDICAL PROBLEMS
(2023)
Article
Surgery
Avideh Maboudi, Reza Fekrazad, Mahmood Moosazadeh, Hanieh Rouhaninezhad, Melika Mollaei, Parastoo Namdar
Summary: This study aimed to compare the efficacy of circumferential supracrestal fiberotomy (CSF) with surgical scalpel, laser CSF, and photobiomodulation for reducing relapse after orthodontic tooth rotation. The results suggest that utilizing photobiomodulation combined with laser CSF or conventional CSF can be effective in reducing relapse.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2023)
Article
Engineering, Biomedical
Abbas Shokri, Hanyeh Moradhaseli, Reza Fekrazad, Mina Jazaeri, Maryam Farhadian
Summary: This study assessed the effect of photobiomodulation therapy (PBMT) with different wavelengths on bone mineral density (BMD) and found it to be effective for enhancing BMD and biomechanical properties. The study evaluated 63 adult female rats and found that PBMT with wavelengths of 660 nm, 810 nm, and 940 nm at a constant energy density of 4 J/cm(2) significantly improved BMD and biomechanical properties.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Anthony E. Lang, Zahra Azad, Seyed Amir Hassan Habibi, Afagh Alavi, Gholamali Shahidi, Maziar Emamikhah, Ahmad Chitsaz
Summary: Among 122 genetically confirmed NBIA patients, KRS had the best survival and longest preservation of ambulation ability, while classical PKAN and MPAN patients showed similar progression patterns in loss of ambulation ability, with MPAN patients having a slower progression to death. Spasticity was identified as the most significant factor associated with death.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
E. Amini, R. Klein
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
E. Amini, R. Klein
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Alfonso Fasano, Zahra Azad, Shahnaz Miri, Seyed Amir Hassan Habibi, Maziar Emamikhah, Reza Mirshahi, Mohammad Taghi Joghataei, Zeinab Gholibeigian, Khalil Ghasemi Falavarjani
Summary: Observing pathological structural and functional neurovascular changes in NBIA patients may provide an opportunity to elucidate the underlying mechanisms and differential retinal biomarkers in NBIA subtypes.
MOVEMENT DISORDERS
(2023)
Review
Surgery
Pouyan Razavi, Aryan Jafari, Paolo Vescovi, Reza Fekrazad
Summary: This study conducted a systematic review to evaluate the efficacy of photobiomodulation (PBM) as an adjunct therapy for medication-related osteonecrosis of the jaw (MRONJ). The results indicated that PBM can significantly improve the outcomes of MRONJ treatment, although surgical intervention is still recommended for complete healing of the lesions.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Review
Engineering, Biomedical
Katayoon Montazeri, Mohammad Farhadi, Reza Fekrazad, Samira Chaibakhsh, Saeid Mahmoudian
Summary: This study systematically reviewed the use of photobiomodulation therapy (PBMT) for the treatment of mood disorders and found that PBMT is strongly recommended for moderate to severe major depressive disorder and recommended for anxiety disorder. More research is needed to recommend this therapeutic method for bipolar disorder.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Engineering, Biomedical
Leila Gholami, Saeid Afshar, Aliasghar Arkian, Masood Saeidijam, Seyedeh Sareh Hendi, Roghayeh Mahmoudi, Khatereh Khorsandi, Hadi Hashemzehi, Reza Fekrazad
Summary: The effect of near infrared laser irradiation on proliferation and osteogenic differentiation of buccal fat pad-derived stem cells and the role of transient receptor potential channels were investigated in this study. The results showed that pulsed laser irradiation had the best cell viability and promoted osteogenic differentiation. Furthermore, Capsazepine inhibited the osteogenic differentiation of the cells.
LASERS IN MEDICAL SCIENCE
(2022)