Article
Immunology
Guiyi Ji, Miaomiao Zhang, Qianqian Liu, Shouquan Wu, Yu Wang, Guo Chen, Andrew J. Sandford, Jian-Qing He
Summary: The study found that single nucleotide polymorphisms of the NFE2L2 gene are associated with susceptibility to tuberculosis, potentially impacting the occurrence of tuberculosis through regulation of NFE2L2's transcriptional activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alexander L. Chu, Leonid W. Lecca, Roger Calderon, Carmen C. Contreras, Rosa M. Yataco, Zibiao Zhang, Mercedes C. Becerra, Megan B. Murray, Chuan-Chin Huang
Summary: This study found that the adverse effects of smoking on the transmissibility of tuberculosis are significantly reduced shortly after quitting smoking, emphasizing the importance of smoking cessation interventions in tuberculosis control.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Zirwatul Adilah Aziz, Noorliza Mohamad Noordin, Wan Mazlina Wan Mohd, Mohd Amin Kasim
Summary: Diagnosis and treatment of tuberculosis infection (TBI) are crucial for tuberculosis elimination. A new digital lateral flow assay, QIAreach QuantiFERON-TB (QIAreach QFT), showed high agreement with QuantiFERON-TB Gold Plus (QFT-Plus) assay in terms of sensitivity, specificity, and overall agreement. QIAreach QFT could serve as an accurate and reliable point-of-need test for TB infection diagnosis, especially in decentralized settings with limited laboratory expertise and infrastructure.
Article
Immunology
Jessica Marie Medrano, Pauline Maiello, Tara Rutledge, Jaime Tomko, Mark A. Rodgers, Daniel Fillmore, L. James Frye, Christopher Janssen, Edwin Klein, JoAnne L. Flynn, Philana Ling Lin
Summary: Using a nonhuman primate model, researchers identified patterns of latency in Mycobacterium tuberculosis infection outcomes. The study emphasized the importance of understanding the clinical spectrum and risk factors associated with severe disease in order to tackle latent infection.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, Chen Seong Wong, Liang Shen, Yee Sin Leo, Barnaby Young, Sophia Archuleta, Catherine W. M. Ong
Summary: The study found that screening for latent TB infection is low among HIV-TB co-infected patients in Singapore, and initiation of ART treatment may be delayed for some patients. It was also noted that pulmonary TB patients with HIV can still be infectious despite showing a normal chest x-ray.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Nicole C. Ammerman, Eric L. Nuermberger, Andrew Owen, Steve P. Rannard, Caren Freel Meyers, Susan Swindells
Summary: This article provides an overview of the specific considerations and current preclinical advancements related to the development of long-acting technologies for tuberculosis drugs to treat latent infection, including target product profiles, suitability of drugs for long-acting formulations, ongoing research efforts, and translation to clinical studies.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ednelza da Silva Graca Amoras, Thais Gouvea de Morais, Rafaella do Nascimento Ferreira, Samara Tatielle Monteiro Gomes, Francisca Dayse Martins de Sousa, Iury de Paula Souza, Ricardo Ishak, Antonio Carlos Rosario Vallinoto, Maria Alice Freitas Queiroz
Summary: This study investigated the association between genetic variations in cytokine genes, plasma cytokine levels, and the development of tuberculosis (TB) and latent tuberculosis infection (LTBI). The findings suggest that certain genetic variations in cytokine genes are associated with an increased risk of TB, and TB patients have distinct cytokine profiles compared to other groups.
Article
Immunology
John Walles, Niclas Winqvist, Stefan R. Hansson, Erik Sturegard, Haitham Baqir, Anna Westman, Torbjoern Kjerstadius, Thomas Schon, Per Bjorkman
Summary: Among immigrant women seeking antenatal care in Sweden, Tuberculosis infection (TBI) was independently associated with adverse pregnancy outcomes, including stillbirth, severe preeclampsia, low birthweight, and emergency cesarean section. Further studies are needed to confirm these findings and investigate mechanisms involved.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Alice Halliday, Tereza Masonou, Mica R. Tolosa-Wright, Yanping Guo, Long Hoang, Robert Parker, Aime Boakye, Yemisi Takwoingi, Amarjit Badhan, Pooja Jain, Ishita Marwah, Luis C. Berrocal-Almanza, Jonathan Deeks, Peter Beverley, Onn Min Kon, Ajit Lalvani
Summary: Measurement of Mtb-specific cellular immune signatures by flow cytometry can differentiate active TB from LTBI, improving and accelerating the diagnosis of tuberculosis.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ping-Huai Wang, Ming-Fang Wu, Chi-Yu Hsu, Shu-Yung Lin, Ya-Nan Chang, Ho-Shen Lee, Yu-Feng Wei, Chin-Chung Shu
Summary: LTBI is associated with increased CD14+ monocytes and low PD-L2 expression, while the increased expression of immune checkpoints over all immune cells might be due to Mycobacterium tuberculosis related immune exhaustion, which decreased after treatment.
Review
Respiratory System
Giovanni Battista Migliori, David Dowdy, Justin T. Denholm, Lia D'Ambrosio, Rosella Centis
Summary: Tuberculosis elimination and pre-elimination were initially considered achievable in low TB incidence countries in the 1990s, but it is now clear that a significant acceleration of efforts is needed to achieve pre-elimination in the next decade. This review provides a framework for near-term progress towards TB pre-elimination, with different stages benchmarked to specific levels of TB incidence in each country. The framework allows for tailored strategies and targets to be set, and prioritizes certain activities for more rapid progress.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Christian Shleider Carnero Canales, Jessica Marquez Cazorla, Andre Henrique Furtado Torres, Eloise T. Monteiro Filardi, Leonardo Delello Di Filippo, Paulo Inacio Costa, Cesar Augusto Roque-Borda, Fernando Rogerio Pavan
Summary: This article reviews the latest scientific evidence on new diagnostic approaches and emerging therapeutic treatments for latent tuberculosis infection (LTBI). New diagnostic tests based on molecular diagnostics, pulmonary immunity, epigenetics, metabolomics, and next-generation MTB antigen-based skin test (TBST) show potential for accurately distinguishing between LTBI and active TB. Therapeutic options include anti-LTBI drugs, anti-resistant TB drugs, and innovative candidates in preclinical and clinical stages. However, further research and clinical evidence are needed to validate the effectiveness and safety of these new approaches.
Article
Immunology
Ying Luo, Ying Xue, Yimin Cai, Qun Lin, Guoxing Tang, Huijuan Song, Wei Liu, Liyan Mao, Xu Yuan, Yu Zhou, Weiyong Liu, Shiji Wu, Ziyong Sun, Feng Wang
Summary: Inadequate tuberculosis diagnostics, especially in discriminating between active TB and latent TB infection, are major obstacles in disease burden reduction. The study investigated the role of lymphocyte non-specific function detection for TB diagnosis. Results show that CD4(+) T cell non-specific function has the potential for differentiating T-SPOT results, and the three-index diagnostic model is a potent tool for identifying different events in TB infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuchen Liu, Lifan Zhang, Fengying Wu, Ye Liu, Yuanchun Li, Yan Chen
Summary: This study identified a pyroptosis-related signature in the pathogenic framework of ATB and developed a diagnostic model with high efficiency and accuracy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Hyung Woo Kim, Jinsoo Min, Joon Young Choi, Ah Young Shin, Jun-Pyo Myong, Yunhee Lee, Hyeon Woo Yim, Hyunsuk Jeong, Sanghyuk Bae, Hoyong Choi, Hyekyung In, Ahyoung Park, Miri Jang, Hyeon-Kyoung Koo, Sung-Soon Lee, Jae Seuk Park, Ju Sang Kim
Summary: The South Korean government launched a national LTBI screening program in 2016, covering over 1.6 million people in congregate settings. This study aims to analyze LTBI prevalence and risk factors in each setting, and investigate the proportion of LTBI pool covered by the current national strategy.
FRONTIERS IN PUBLIC HEALTH
(2023)