Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pediatrics
Ying-Hao Deng, Ping Yan, Ning-Ya Zhang, Xiao-Qin Luo, Xiu-Fen Wang, Shao-Bin Duan
Summary: AKD is common in hospitalized pediatric patients with AKI, with stages 2-3 being associated with higher rates of adverse outcomes at 30 and 90 days. AKI stages 2 and 3, as well as glomerulonephritis, are predictive factors for the development of AKD stage 2-3. Early recognition and management of AKD in pediatric AKI patients are crucial for improving outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Physiology
Xue Hong, Yanni Zhou, Dedong Wang, Fuping Lyu, Tianjun Guan, Youhua Liu, Liangxiang Xiao
Summary: The study found that in vivo expression of exogenous Wnt1 before ischemia/reperfusion injury (IRI) protected mice against acute kidney injury (AKI) and impeded its progression to chronic kidney disease (CKD. In contrast, pretreatment with ICG-001 had no effect on renal Wnt/beta-catenin signaling or the progression of AKI to CKD. Exogenous Wnt1 suppressed proapoptotic proteins and reduced inflammatory responses in AKI and CKD mice.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Taisei Nagasaki, Hitoshi Maeda, Kazuaki Taguchi, Hiroki Yanagisawa, Kento Nishida, Kazuki Kobayashi, Naoki Wada, Isamu Noguchi, Ryota Murata, Hiromi Sakai, Hiroaki Kitagishi, Junji Saruwatari, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Summary: Renal ischemia-reperfusion can cause tubular cell damage, leading to acute kidney injury and chronic kidney disease. This study explores the potential of three molecules, HIF-1 alpha, AMPK, and Nrf2, to protect tubular cells from these disorders. The researchers found that CO-enriched red blood cell therapy can effectively prevent the pathological conditions of AKI and AKI to CKD by ameliorating hypoxia inducible tubular cell damage.
Article
Urology & Nephrology
Simon Sawhney, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jorgensen, Simon Kok Jensen, Paul E. Ronksley, Zhi Tan, Marcello Tonelli, Heather Walker, Matthew T. James
Summary: Using a consistent analytical approach and KDIGO criteria, the study found that the incidence and prognosis of AKI and AKD are consistent in three high-income countries. The age-standardized incidence rates were similar across regions and years, and the standardized 1-year mortality varied among patients meeting different creatinine criteria.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Kerry L. Horne, Daniela Viramontes-Horner, Rebecca Packington, John Monaghan, Susan Shaw, Aleli Akani, Timothy Reilly, Thomas Trimble, Grazziela Figueredo, Nicholas M. Selby
Summary: Acute kidney injury (AKI) is associated with adverse long-term outcomes, including kidney disease progression, heart failure episodes, and mortality. The study found that AKI is strongly associated with kidney disease progression and further episodes of AKI increase the risk for progression. However, the association with mortality and heart failure becomes insignificant when adjusted for three-month kidney function and albumin:creatinine ratio.
KIDNEY INTERNATIONAL
(2023)
Review
Oncology
Kim T. Vuong, Catherine Joseph, Joseph R. Angelo
Summary: While AKI after HCT is well-described in pediatric patients, limited literature exists regarding the long-term renal consequences, development of CKD, and CKD care in these patients. CKD affects almost 50% of patients after HCT with various causes, and as renal function declines, mortality increases. This review aims to summarize definitions, etiologies, and management strategies for AKI and CKD post-HCT, with a focus on early identification, intervention, and discussion of ESKD and renal transplant.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ming-Tso Yan, Chia-Ter Chao, Shih-Hua Lin
Summary: Chronic kidney disease (CKD) is characterized by irreversible structural or functional kidney damages, increasing the risk of poor outcomes. Due to the heterogeneous origins and uncertain pathogenesis, efficacious therapies for CKD remain challenging. Therefore, prevention of CKD progression and complications, as well as controlling acute kidney injury, are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Chujin Cao, Ying Yao, Rui Zeng
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are major global health concerns, with the immune system playing a crucial role. Lymphocytes are key players in inflammation and kidney injury, with different subtypes having distinct roles in kidney protection and damage.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Food Science & Technology
Yueqing Hui, Jin Zhao, Zixian Yu, Yuwei Wang, Yunlong Qin, Yumeng Zhang, Yan Xing, Mei Han, Anjing Wang, Shuxian Guo, Jinguo Yuan, Yueru Zhao, Xiaoxuan Ning, Shiren Sun
Summary: Tryptophan metabolism is closely related to the pathophysiology of AKI and CKD, and its metabolites act as biomarkers that facilitate early diagnosis. The accumulation of tryptophan metabolites and gut dysbiosis accelerate the progression of AKI and CKD. Targeting tryptophan metabolism has become a research hotspot for intervention in AKI and CKD.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yitan Zhu, Dehua Bi, Milda Saunders, Yuan Ji
Summary: This study developed a pipeline to process longitudinal electronic health records and constructed a recurrent neural network model to predict the progression of chronic kidney disease. The model achieved high prediction accuracy using time-series records of estimated glomerular filtration rate as the sole variable. Incorporating additional clinical variables further improved the prediction accuracy.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Lingyu Xu, Chenyu Li, Na Li, Long Zhao, Zhihui Zhu, Xiaosu Zhang, Jing Wang, Jun Zhao, Junyan Huang, Zhihua Zheng, Hans-Joachim Anders, Yan Xu
Summary: This study investigates the risk factors and prognosis of acute/subacute renal impairment among Chinese inpatients. It finds that AKI followed by AKD is associated with a higher risk of long-term mortality compared to AKD without AKI and recovery from AKI. The study also suggests that AKD criteria are strongly associated with overall survival and de novo CKD, while AKI criteria have a relatively lower ability to predict the risk of overall survival and CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Jose Portoles, Paula Lopez-Sanchez, Leyre Martin-Rodriguez, Maria Luisa Serrano-Salazar, Maria Valdenebro-Recio, Antonio Ramos, Rosa Maria Malo, Felipe Zalamea, Juan Manuel Martin-Giner, Maria Marques, Alberto Ortiz
Summary: This study analyzed the epidemiological characteristics of chronic kidney disease (CKD) and acute kidney injury (AKI) in 2878 hospitalized COVID-19 patients in Madrid, and found that CKD and AKI were independent risk factors for in-hospital mortality.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Ping Yan, Xiang-Jie Duan, Yu Liu, Xi Wu, Ning-Ya Zhang, Fang Yuan, Hao Tang, Qian Liu, Ying-Hao Deng, Hong-Shen Wang, Mei Wang, Shao-bin Duan
Summary: A study on 2,556 hospitalized AKI patients in three tertiary hospitals in China in 2015 found that AKD is common among these patients. AKD stage 2-3 provides additional predictive value for adverse outcomes at 30 days and one year compared to AKD stage 0.
Article
Transplantation
Takayuki Hamano, Takahiro Imaizumi, Takeshi Hasegawa, Naohiko Fujii, Hirotaka Komaba, Masahiko Ando, Masaomi Nangaku, Kosaku Nitta, Hideki Hirakata, Yoshitaka Isaka, Takashi Wada, Shoichi Maruyama, Masafumi Fukagawa
Summary: The CGA classification is more valuable than the GA classification in predicting kidney disease outcomes, and incorporating a prior biopsy-proven diagnosis significantly improves the accuracy of outcome prediction.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Simon Sawhney, Tom Blakeman, Dimitra Blana, Dwayne Boyers, Nick Fluck, Mintu Nath, Shona Methven, Magdalena Rzewuska, Corri Black
Summary: Inequities in kidney care exist even in high-income countries, with area-level deprivation having a greater impact in the earlier stages of the disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Kaitlyn E. Watson, Kirnvir Dhaliwal, Sandra Robertshaw, Nancy Verdin, Eleanor Benterud, Nicole Lamont, Kelsea M. Drall, Kerry McBrien, Maoliosa Donald, Ross T. Tsuyuki, David J. T. Campbell, Neesh Pannu, Matthew T. James
Summary: This study aimed to establish recommendations for Sick day medication guidance (SDMG) through consensus among clinical experts. A multidisciplinary panel of 26 clinicians from 4 countries reached consensus on 42 specific recommendations, including triggers for SDMG, signs for urgent contact with healthcare providers, and self-management strategies for patients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medicine, General & Internal
David J. McLernon, Daniele Giardiello, Ben Van Calster, Laure Wynants, Nan van Geloven, Maarten van Smeden, Terry Therneau, Ewout W. Steyerberg, STRATOS Initiative
Summary: Risk prediction models need validation to assess their performance. This article focuses on evaluating predictions and improving clinical decision making using survival models based on Cox proportional hazards regression. The authors present a case study on breast cancer patients, where a Cox regression model is developed and validated for prediction of recurrence or death.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
David J. McLernon, Siladitya Bhattacharya
Summary: The improvement in IVF cryopreservation techniques has led to an increase in elective single embryo transfer, reducing multiple pregnancy rates. Clinical prediction models are useful in estimating couples' chances of success and guiding future treatment. This review discusses different models for predicting cumulative live birth and recommends when and which models should be used.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Obstetrics & Gynecology
Christopher Allen, David McLernon, Sohinee Bhattacharya, Abha Maheshwari
Summary: Pregnancies conceived with donor sperm have a lower odds of early pregnancy loss and ectopic pregnancy compared to pregnancies conceived with partner sperm.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Denise Forshaw, Emma C. Wall, Gordon Prescott, Hakim-Moulay Dehbi, Angela Green, Emily Attree, Lyth Hismeh, William D. Strain, Michael G. Crooks, Caroline Watkins, Chris Robson, Rajarshi Banerjee, Paula Lorgelly, Melissa Heightman, Amitava Banerjee
Summary: This study is a multi-centre, cluster-randomised clinical trial evaluating the effectiveness of an integrated care pathway for long COVID (LC). The trial includes medical imaging examinations, a digital rehabilitation platform, and a drug trial. It is being conducted in 6-10 LC clinics in the UK and aims to assess the reduction in fatigue and other physical, psychological, and functional outcomes in adults with LC after 3 months of the pathway of care.
Article
Urology & Nephrology
Tyrone G. Harrison, Brenda R. Hemmelgarn, Matthew T. James, Simon Sawhney, Braden J. Manns, Marcello Tonelli, Shannon M. Ruzycki, Kelly B. Zarnke, Todd A. Wilson, Deirdre McCaughey, Paul E. Ronksley
Summary: This study aimed to develop and validate risk prediction models for patients with kidney failure undergoing non-cardiac surgery. The models including comorbidities and laboratory variables showed improved accuracy in risk stratification and provided the greatest potential net benefit for guiding perioperative decisions.
Review
Urology & Nephrology
Raymond Vanholder, Lieven Annemans, Marion Braks, Edwina A. Brown, Priya Pais, Tanjala S. Purnell, Simon Sawhney, Nicole Scholes-Robertson, Benedicte Stengel, Elliot K. Tannor, Vladimir Tesar, Arjan van der Tol, Valerie A. Luyckx
Summary: Kidney disease risk and outcomes are strongly influenced by inequities across its clinical course, including insufficient investment and social/structural inequities. Access to affordable kidney care is highly unequal, leading to financial hardship for vulnerable populations. Advocacy and leadership by the nephrology community are crucial to address and dismantle these inequities.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Transplantation
Simon Sawhney, William Ball, Samira Bell, Corri Black, Christian F. Christiansen, Uffe Heide-Jorgensen, Simon K. Jensen, Emilie Lambourg, Paul E. Ronksley, Zhi Tan, Marcello Tonelli, Matthew T. James
Summary: A federated analysis of four population-based cohorts from Canada, Denmark and Scotland was conducted to evaluate kidney function recovery after AKI and AKD. Results at 1 year were consistent across cohorts, with differences in outcomes associated with AKD by age, sex, and comorbidities. Older males were more likely to die, while younger females were less likely to recover.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Obstetrics & Gynecology
D. Cimadomo, M. J. de los Santos, G. Griesinger, G. Lainas, N. Le Clef, D. J. McLernon, D. Montjean, B. Toth, N. Vermeulen, N. Macklon
Summary: This article provides the first ESHRE good practice recommendations for defining and managing recurrent implantation failure (RIF) in patients undergoing ART. RIF is a challenge in the ART clinic, with numerous investigations and interventions offered and applied without clear biological rationale or evidence of benefit. The recommendations include investigating causes and contributing factors of RIF, as well as improving the chances of a successful pregnancy.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Edwin-Amalraj Raja, Siladitya Bhattacharya, Abha Maheshwari, David J. McLernon
Summary: This study compared perinatal outcomes of fresh blastocyst transfer and fresh cleavage stage embryo transfer in singletons, twins, and singleton siblings. The results showed that singleton babies born following fresh blastocyst transfer had a lower risk of being small for gestational age (SGA) or having a congenital anomaly compared to those born following fresh cleavage stage transfer. However, singleton babies born following fresh blastocyst transfer were at a higher risk of being large for gestational age (LGA). Twins resulting from fresh blastocyst transfer were also at a slightly higher risk of preterm birth. These findings highlight the potential benefits and risks associated with blastocyst stage transfer.
HUMAN REPRODUCTION OPEN
(2023)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Cardiac & Cardiovascular Systems
Tyrone G. Harrison, Brenda R. Hemmelgarn, Matthew T. James, Simon Sawhney, Ngan N. Lam, Shannon M. Ruzycki, Todd A. Wilson, Paul E. Ronksley
Summary: The revised cardiac risk index (RCRI) performs poorly and overestimates risk in the population with kidney failure, indicating the need for limitations on its use. There is a need for novel perioperative models for this population.