Article
Endocrinology & Metabolism
Ying He, Jincheng Feng, Bo Zhang, Qiong Wu, Yongjie Zhou, Diao He, Daofeng Zheng, Jiayin Yang
Summary: This study utilized Mendelian randomization (MR) analysis to explore the causality between serum uric acid (SUA) levels and the risk of cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D). The results did not find supporting evidence for a causal association between SUA levels and the risk of heart failure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Minxiao Jiang, Liangliang Ren, Songzan Chen, Gonghui Li
Summary: The study utilizing Mendelian randomization did not find a significant association between serum uric acid levels and cancer risk. Analysis of eight common site-specific cancers did not show any significant correlation with serum uric acid levels.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Guozhi Jiang, Andrea O. Luk, Claudia H. T. Tam, Risa Ozaki, Cadmon K. P. Lim, Elaine Y. K. Chow, Eric S. Lau, Alice P. S. Kong, Baoqi Fan, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y. Leung, Man-wo Tsang, Grace Kam, Ip Tim Lau, June K. Li, Vincent T. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Nelson L. S. Tang, Yu Huang, Hui-yao Lan, Richard A. Oram, Cheuk Chun Szeto, Wing Yee So, Juliana C. N. Chan, Ronald C. W. Ma
Summary: This study aims to evaluate the long-term impact of acute kidney injury (AKI) on the progression of diabetic kidney disease (DKD) and all-cause mortality, as well as investigate the determinants of AKI in Chinese patients with type 2 diabetes (T2D). The findings suggest that patients with AKI have a higher risk of developing CKD, ESRD, and all-cause death. Additionally, a polygenic risk score (PRS) composed of single nucleotide polymorphisms (SNPs) associated with serum uric acid (SUA) was found to be associated with AKI and CKD in both discovery and replication cohorts.
Article
Endocrinology & Metabolism
Shiwei Li, Yuhong Fu, Yue Liu, Xinxin Zhang, Haijun Li, Lei Tian, Lin Zhuo, Ming Liu, Jingqiu Cui
Summary: This study used Mendelian randomization analysis to investigate the causal relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). The results showed that NAFLD is associated with elevated SUA levels, but elevated SUA levels do not have a causal association with the risk of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Ya-Nan Ou, Bing Zhao, Yan Fu, Ze-Hu Sheng, Pei-Yang Gao, Lan Tan, Jin-Tai Yu
Summary: This study using a Mendelian randomization design found a causal relationship between elevated serum uric acid levels and the risk of Alzheimer's disease, but further research is needed to verify these findings.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Endocrinology & Metabolism
Xueting Hu, Shuang Rong, Qiang Wang, Taoping Sun, Wei Bao, Liangkai Chen, Liegang Liu
Summary: Elevated plasma uric acid levels are associated with higher risk of insulin resistance, with a more pronounced association observed among women. However, the study does not support a causal role of plasma uric acid on insulin resistance in newly diagnosed T2D patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ningyuan Liu, Ge Wang, Chao Liu, Jiayi Liu, Shengyuan Huang, Yong Zhou, Enhua Xiao
Summary: This study investigates the potential causal relationship between NAFLD and complications in T1D and T2D using two-sample MR analysis. The results suggest a causal association between genetically driven NAFLD and early-stage kidney disease in T1D, as well as a suggestive causal association with ketoacidosis in T1D. However, there is insufficient evidence to support a causal association between NAFLD and retinopathy in T1D, as well as ketoacidosis, nephropathy, and retinopathy in T2D.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Peizhi Deng, Zhixin Li, Bin Yi, Yiping Leng
Summary: This study conducted a Mendelian randomization analysis to explore the relationship between T1DM and IgAN. The analysis provided evidence that T1DM may be a risk factor for the onset of IgAN, potentially driven by LDL-c. Strategies targeting LDL-c should be enhanced in T1DM patients to prevent IgAN.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Manjun Luo, Mengting Sun, Tingting Wang, Senmao Zhang, Xinli Song, Xiaoying Liu, Jianhui Wei, Qian Chen, Taowei Zhong, Jiabi Qin
Summary: This study used two-sample bidirectional mendelian randomization to evaluate the causal relationship between gut microbiota and T1D. The results showed that the Bacteroidetes phylum, Bacteroidia class, and Bacteroidales order of gut microbiota increase the risk of T1D, while the Eubacterium eligens group genus belonging to the Firmicutes phylum decreases the risk of T1D.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jingru Lu, Xiaoshuang Liu, Song Jiang, Shuyan Kan, Yu An, Chunxia Zheng, Xiang Li, Zhihong Liu, Guotong Xie
Summary: The study found that an increase in body mass index was causally associated with a higher risk of diabetic nephropathy and a lower eGFR level in type 2 diabetes patients. The impact of BMI on DN risk was greater in women, but there was no causal association with proteinuria.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Songzan Chen, Fangkun Yang, Tian Xu, Yao Wang, Kaijie Zhang, Guosheng Fu, Wenbin Zhang
Summary: A two-sample Mendelian randomization study found no significant causal effect of genetically predicted serum uric acid levels on the risk of coronary artery disease in patients with diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Jiaxi Fang, Chuxuan Luo, Di Zhang, Qiang He, Lin Liu
Summary: Our study using a Mendelian randomization approach found a positive correlation between diabetic retinopathy and diabetic nephropathy, providing genetic evidence for their association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Li Qian, Yajuan Fan, Fengjie Gao, Binbin Zhao, Bin Yan, Wei Wang, Jian Yang, Xiancang Ma
Summary: Using Mendelian randomization analysis, our study identified 31 metabolites that may causally affect neuroticism, with uric acid showing a negative association and paraxanthine showing a positive association with the risk of neuroticism. This novel insight combining metabolomics with genomics contributes to a better understanding of the pathogenesis of neuroticism.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yang -Wei Cai, Hai-Feng Zhang, Jing-Wei Gao, Zhao -Xi Cai, Jie-Wen Cai, Qing-Yuan Gao, Zhi-Teng Chen, Guang-Hong Liao, Chuan-Rui Zeng, Nuo Chen, Pin -Ming Liu, Jing-Feng Wang, Yang-Xin Chen
Summary: This large prospective study found an inverse association between serum albumin levels and the incidences of diabetes and diabetic microvascular complications. These findings highlight the importance of maintaining optimal nutrient status in reducing the risk of diabetes and its complications.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fanny Jansson Sigfrids, Per-Henrik Groop, Valma Harjutsalo
Summary: This study examined the incidence and temporal trends of albuminuria in type 1 diabetes patients in Finland. The cumulative incidence of severe albuminuria decreased over time, while the incidence of moderate albuminuria remained stable. These findings are important for understanding the complications of type 1 diabetes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Letter
Endocrinology & Metabolism
Erika B. Parente, Stefan Mutter, Lena M. Thorn, Valma Harjutsalo, Per-Henrik Groop
Article
Endocrinology & Metabolism
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn
Summary: This study aims to investigate the prognosis after a first-ever myocardial infarction (MI) in individuals with type 1 diabetes and how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. The study found that individuals with type 1 diabetes have a high cardiovascular and diabetes-related mortality after their first-ever MI, and poor kidney function is associated with high mortality and excessive risk of secondary cardiovascular events.
Article
Clinical Neurology
Victoria Lillback, Marco Savarese, Niina Sandholm, Peter Hackman, Bjarne Udd
Summary: In this retrospective study, the disease progression of 137 TMD patients over 15 years was observed. The main symptoms of TMD patients were walking difficulties and weakness in distal lower limbs. The progression of the weakness was moderate and cardiomyopathy was not developed due to the titin defect alone. These findings provide important information for the accurate identification and therapeutic intervention of TMD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Clinical Neurology
Heli Viljakainen, Elina Engberg, Emma Dahlstrom, Sohvi Lommi, Jari Lahti
Summary: Sleep duration has been associated with obesity, especially bedtime discrepancy between school and non-school days in children. Later bedtime on non-school nights and delay in bedtime compared with school nights are associated with higher BMIz and WtHr, also predicting higher WtHr longitudinally. Promoting early bedtimes, especially on weekends, should be considered to prevent obesity in school-aged children.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop
Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.
Article
Genetics & Heredity
Claire Hill, Seamus M. Duffy, Laura Kettyle, Liane McGlynn, Niina M. Sandholm, Rany Salem, Alex J. Thompson, Elizabeth Swan, Jill Kilner, Peter G. Rossing, Paul Shiels, Maria Lajer, Per-Henrik Groop, Alexander Peter Maxwell, Amy Jayne McKnight, GENIE Consortium
Summary: Diabetic kidney disease (DKD) is a major global health problem characterized by accelerated aging. This study explored features affecting telomere biology and methylation dysregulation in DKD using multi-omics approaches, which may provide useful biomarkers or therapeutic targets.
Article
Endocrinology & Metabolism
Minna Harsunen, Jani Haukka, Valma Harjutsalo, Nina Mars, Anna Syreeni, Taina Harkonen, Annemari Karajaemaki, Jorma Ilonen, Mikael Knip, Niina Sandholm, Paivi Johanna Miettinen, Per-Henrik Groop, Tiinamaija Tuomi
Summary: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, this study found that many individuals with type 1 diabetes still have circulating C-peptide years after diagnosis. The study also identified the correlation between age at diagnosis and decline in C-peptide secretion, as well as the association between polygenic risk scores, clinical factors, and random serum C-peptide concentrations.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Niina Sandholm, Emma H. Dahlstrom, Per-Henrik Groop
Summary: Diabetic kidney disease (DKD) is a severe complication of diabetes, affecting a significant portion of patients. While elevated blood glucose levels play a key role in DKD, it is a complex disease with both genetic and environmental factors contributing to its development. Genome-wide association studies (GWASs) have been valuable in identifying genetic risk factors for DKD, and recent advancements in sequencing techniques have allowed for the discovery of rare genetic variants. Epigenome-wide association studies have also been conducted to explore the role of DNA methylation in DKD. This review aims to summarize the identified genetic and epigenetic risk factors for DKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Valma Harjutsalo, Milla Kallio, Carol Forsblom, Per-Henrik Groop, FinnDiane Study Grp
Summary: This study investigated the impact of diabetic nephropathy and diabetic retinopathy on the risk of chronic limb threatening ischemia (CLTI) in patients with type 1 diabetes. It found that diabetic nephropathy and severe diabetic retinopathy were key risk factors for CLTI in these patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Endocrinology & Metabolism
M. I. Eriksson, A. Syreeni, N. Sandholm, E. H. Dahlstrom, D. Gordin, T. Tatlisumak, J. Putaala, Per-Henrik Groop, J. Martola, L. M. Thorn
Summary: This study aimed to evaluate the association between haptoglobin genotype and cerebral small-vessel disease (SVD). The results showed no significant association between haptoglobin genotype and SVD.
ACTA DIABETOLOGICA
(2023)
