期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 18, 期 5, 页码 365-372出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1600579
关键词
Tumor microenvironment (TME); DNA methylation; Cancer-associated fibroblasts; Cancer-associated immune cells; Epigenetic therapy
类别
资金
- National Cancer Institute [R01CA169702, P50CA062924, R01CA197296]
The tumor microenvironment (TME) plays an important role in supporting cancer progression. The TME is composed of tumor cells, the surrounding tumor-associated stromal cells, and the extracellular matrix (ECM). Crosstalk between the TME components contributes to tumorigenesis. Recently, one of our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells can induce DNA methylation in cancer-associated fibroblasts (CAFs), thereby modifying tumor-stromal interactions in the TME, and subsequently creating a TME that supports tumor growth. Here we summarize recent studies about how DNA methylation affects tumorigenesis through regulating tumorassociated stromal components including fibroblasts and immune cells. We also discuss the potential for targeting DNA methylation for the treatment of cancers.
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