According to Hepatitis C Virus (HCV) Infection Stage, Interleukin-7 Plus 4-1BB Triggering Alone or Combined with PD-1 Blockade Increases TRAF1 low HCV-Specific CD8 + Cell Reactivity

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

(2017) Dominik Wieland et al.   Nature Communications

Hepatitis C virus infection

(2017) Michael P. Manns et al.   Nature Reviews Disease Primers

Hepatitis C Virus RNA Persists in Liver Explants of Most Patients Awaiting Liver Transplantation Treated With an Interferon-Free Regimen

(2016) Martina Gambato et al.   GASTROENTEROLOGY

Effectiveness of Ledipasvir-Sofosbuvir Combination in Patients With Hepatitis C Virus Infection and Factors Associated With Sustained Virologic Response

(2016) Norah A. Terrault et al.   GASTROENTEROLOGY

Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells

(2016) Arielle Klepper et al.   HEPATOLOGY

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192

(2016) Ji Hyun Kim et al.   JOURNAL OF MICROBIOLOGY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Global prevalence of pre-existing HCV variants resistant to direct-acting antiviral agents (DAAs): mining the GenBank HCV genome data

(2016) Zhi-wei Chen et al.   Scientific Reports

New criteria for response assessment: role of minimal residual disease in multiple myeloma

(2015) B. Paiva et al.   BLOOD

A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C

(2015) Solomon Owusu Sekyere et al.   JOURNAL OF HEPATOLOGY

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes

(2014) Christabel Kelly et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trace amounts of sporadically reappearing HCV RNA can cause infection

(2014) Naga Suresh Veerapu et al.   JOURNAL OF CLINICAL INVESTIGATION

Restoration of HCV-specific CD8+ T cell function by interferon-free therapy

(2014) Bianca Martin et al.   JOURNAL OF HEPATOLOGY

Adaptive immune response during hepatitis C virus infection

(2014) Juan Ramón Larrubia   WORLD JOURNAL OF GASTROENTEROLOGY

HCV-specific CD8+ cell detection at week 12 of chronic hepatitis C treatment with PEG-interferon-α2b/ribavirin correlates with infection resolution

(2013) Juan-Ramón Larrubia et al.   CELLULAR IMMUNOLOGY

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined Blockade of Programmed Death-1 and Activation of CD137 Increase Responses of Human Liver T Cells Against HBV, But Not HCV

(2012) Paola Fisicaro et al.   GASTROENTEROLOGY

Hepatitis c virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis

(2012) Shaoyong Li et al.   HEPATOLOGY

Opposing Roles for TRAF1 in the AlternativeversusClassical NF-κB Pathway in T Cells

(2012) Ann J. McPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation

(2012) J. R. Larrubia et al.   JOURNAL OF VIRAL HEPATITIS

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127− HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection

(2011) Juan R. Larrubia et al.   CELLULAR IMMUNOLOGY

Loss of the signaling adaptor TRAF1 causes CD8+T cell dysregulation during human and murine chronic infection

(2011) Chao Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sporadic Reappearance of Minute Amounts of Hepatitis C Virus RNA After Successful Therapy Stimulates Cellular Immune Responses

(2010) Naga Suresh Veerapu et al.   GASTROENTEROLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

HCV+ Hepatocytes Induce Human Regulatory CD4+ T Cells through the Production of TGF-β

(2010) Caroline H. T. Hall et al.   PLoS One

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

IFN-γ-STAT1 signal regulates the differentiation of inducible Treg: Potential role for ROS-mediated apoptosis

(2009) Jae-Hoon Chang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells

(2008) Johanna Kober et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

(2008) H. Radziewicz et al.   JOURNAL OF VIROLOGY